Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases

Beisner, Julia; Gonzalez‐Granda, Anita; Basrai, Maryam; Damms-Machado, Antje; Bischoff, Stephan C.

doi:10.3390/nu12113444

Cited by 50 publications

(48 citation statements)

References 78 publications

(63 reference statements)

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“…Erysipelatoclostridium is a butyrate-producing bacterium [ 48 ]. It has been discovered to be enhanced in DSS-treated colitis mice [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Barley Leaf Insoluble Dietary Fiber Alleviated Dextran Sulfate Sodium-Induced Mice Colitis by Modulating Gut Microbiota

Tian

et al. 2021

Nutrients

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Supplementation of dietary fiber has been proved to be an effective strategy to prevent and relieve inflammatory bowel disease (IBD) through gut microbiota modulation. However, more attention has been paid to the efficacy of soluble dietary fiber than that of insoluble dietary fiber (IDF). In the present study, we investigated whether IDF from barley leaf (BLIDF) can inhibit gut inflammation via modulating the intestinal microbiota in DSS-induced colitis mice. The mice were fed 1.52% BLIDF-supplemented diet for 28 days. Results demonstrated that feeding BLIDF markedly mitigated DSS-induced acute colitis symptoms and down-regulated IL-6, TNF-α, and IL-1β levels in the colon and serum of colitis mice. BLIDF supplementation effectively reduced the abundance of Akkermansia and increased the abundance of Parasutterella, Erysipelatoclostridium, and Alistipes. Importantly, the anti-colitis effects of BLIDF were abolished when the intestinal microbiota was depleted by antibiotics. Furthermore, the targeted microbiota-derived metabolites analysis suggested that BLIDF feeding can reverse the DSS-induced decline of short-chain fatty acids and secondary bile acids in mice feces. Finally, BLIDF supplementation elevated the expression of occludin and mucin2, and decreased the expression of claudin-1 in colons of DSS-treated mice. Overall, our observations suggest that BLIDF exerts anti-inflammatory effects via modulating the intestinal microbiota composition and increasing the production of microbiota-derived metabolites.

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“…Erysipelatoclostridium is a butyrate-producing bacterium [ 48 ]. It has been discovered to be enhanced in DSS-treated colitis mice [ 49 , 50 ].…”

Section: Discussionmentioning

confidence: 99%

Barley Leaf Insoluble Dietary Fiber Alleviated Dextran Sulfate Sodium-Induced Mice Colitis by Modulating Gut Microbiota

Tian

et al. 2021

Nutrients

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“…High fructose corn syrup supplemented foods resulted in destruction of beneficial butyrate producing gut bacteria and problematic microbial metabolism of host lipids. In contrast, naturally occurring fructose as part of a fruit-based diet appeared to produce an opposite beneficial effect [114].…”

Section: Tastementioning

confidence: 99%

“…A final point is the effect of high fructose corn syrup specifically on the human microbiome. In a study by Beisner et al [114], researchers found that different formulation of foods containing fructose resulted in different gut microbiome compositions and metabolism. High fructose corn syrup supplemented foods resulted in destruction of beneficial butyrate producing gut bacteria and problematic microbial metabolism of host lipids.…”

Section: Tastementioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert¹

2021

Preprint

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The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to co-morbid NCDs.

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“…A final point is the effect of high fructose corn syrup specifically on the human microbiome. In a study by Beisner et al [ 114 ], researchers found that different formulation of foods containing fructose resulted in different gut microbiome compositions and metabolism. High fructose corn syrup supplemented foods resulted in the destruction of beneficial butyrate producing gut bacteria and problematic microbial metabolism of host lipids.…”

Section: Who Behavioral Modification #1: Eat a Healthy Diet (In Spite Of The Microbiota-driven Sense Control)mentioning

confidence: 99%

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Dietert

2021

Biomedicines

View full text Add to dashboard Cite

The is a sequential article to an initial review suggesting that Microbiome First medical approaches to human health and wellness could both aid the fight against noncommunicable diseases and conditions (NCDs) and help to usher in sustainable healthcare. This current review article specifically focuses on public health programs and initiatives and what has been termed by medical journals as a catastrophic record of recent failures. Included in the review is a discussion of the four priority behavioral modifications (food choices, cessation of two drugs of abuse, and exercise) advocated by the World Health Organization as the way to stop the ongoing NCD epidemic. The lack of public health focus on the majority of cells and genes in the human superorganism, the microbiome, is highlighted as is the “regulatory gap” failure to protect humans, particularly the young, from a series of mass population toxic exposures (e.g., asbestos, trichloroethylene, dioxin, polychlorinated biphenyls, triclosan, bisphenol A and other plasticizers, polyfluorinated compounds, herbicides, food emulsifiers, high fructose corn syrup, certain nanoparticles, endocrine disruptors, and obesogens). The combination of early life toxicity for the microbiome and connected human physiological systems (e.g., immune, neurological), plus a lack of attention to the importance of microbial rebiosis has facilitated rather than suppressed, the NCD epidemic. This review article concludes with a call to place the microbiome first and foremost in public health initiatives as a way to both rescue public health effectiveness and reduce the human suffering connected to comorbid NCDs.

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Fructose-Induced Intestinal Microbiota Shift Following Two Types of Short-Term High-Fructose Dietary Phases

Cited by 50 publications

References 78 publications

Barley Leaf Insoluble Dietary Fiber Alleviated Dextran Sulfate Sodium-Induced Mice Colitis by Modulating Gut Microbiota

Barley Leaf Insoluble Dietary Fiber Alleviated Dextran Sulfate Sodium-Induced Mice Colitis by Modulating Gut Microbiota

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

Microbiome First Approaches to Rescue Public Health and Reduce Human Suffering

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