Fructose-induced metabolic disturbances in rats and its impact on stomach endocrine cell number and smooth muscle contractility

Gulubova, Maya; Toleкova, A.; Ivanova, Koni; Hamza, S.; Hadzhi, M.; Chonov, Dimitar; Ananiev, Julian

doi:10.1080/13813455.2018.1555601

Cited by 4 publications

(5 citation statements)

References 42 publications

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“…2). This result differs from the study findings of Gulubova et al [27]. The reason for obtaining different results in the studies may be due to the differences in the tissue, experimental model and duration.…”

Section: Resultscontrasting

confidence: 87%

“…It has been reported that it reduced apoptosis in crypt cells in intestinal damage induced by ischemia reperfusion [16]. It has been determined that the number of gastrin-positive endocrine cells decreased in corpus and antrum parts of stomach in streptozotocin and fructose diet administered rats compared to control group [27]. In this study, gastrin immunoreactive cells were localized in epithelial layer and crypts.…”

Section: Resultsmentioning

confidence: 54%

“…It has been found that somatostatin immunoreactive cells were localized in villus epithelium and crypts of small intestine [11]. In addition, it has been determined that the number of somatostatin-producing D cells increased in cardia and antrum parts of stomach but decreased in corpus part of stomach in streptozotocin and fructose dietadministered rats compared to control group [27]. Also, it has been detected that 3-aminoisobutyric acid (BAIBA) metabolite was higher in plasmas of subjects with high L and D cell density in duodenal biopsies of individuals with metabolic syndrome.…”

Section: Resultsmentioning

confidence: 99%

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The effect of fructose–induced metabolic syndrome on the histological structure and enteroendocrine cells in duodenum of rats

Yildiz,

Kum

2024

RC FCV-LUZ

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Metabolic syndrome is a worldwide common disorder that coexists with abdominal obesity, high blood pressure, dyslipidemia, and high blood sugar. The purpose of this investigation was to examine the effects of metabolic syndrome on enteroendocrine cell count and histological structure in duodenum. The rats were separated into control and metabolic syndrome groups. Duodenum tissue sections were stained with hematoxylin–eosin for histomorphological examinations. Additionally, immunohistochemical analysis of duodenum showed the presence of somatostatin and gastrin immunoreactive cells. In duodenum, it was found that villus height, villus width, villus area and thickness of tunica muscularis significantly increased in metabolic syndrome group compared to control group. Similarly, it was observed that the numbers of somatostatin and gastrin immunoreactive cells in duodenum were significantly higher in metabolic syndrome group compared to control group. As a result, it was revealed that metabolic syndrome caused structural disorders in duodenum and changed enteroendocrine cell population. Thus, it can be assumed that intestinal functions may be negatively affected due to metabolic syndrome and digestive physiology may be disrupted.

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Section: Resultscontrasting

confidence: 87%

Section: Resultsmentioning

confidence: 54%

Section: Resultsmentioning

confidence: 99%

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The effect of fructose–induced metabolic syndrome on the histological structure and enteroendocrine cells in duodenum of rats

Yildiz,

Kum

2024

RC FCV-LUZ

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“…In animal models was reported that ghrelin reduces the release of pro-inflammatory cytokines [7] and stimulates the release of the anti-inflammatory cytokine IL-10 by T lymphocytes and macrophages [16]. Gulubova et al, 2019, proved that ghrelin positive MCs number in the muscle layer of the stomach is significantly decreased in rats with metabolic disturbances which is related with lowered power of gastric muscle contraction [5]. It was found that that circulating ghrelin levels are deeply diminished in patients with gastric cancer related with the progression of gastric cancer [11].…”

Section: Discussionmentioning

confidence: 99%

Mast Cells in Rat Pulmonary Pleura

Ivanova,

Stefanov,

Pilicheva

2024

AMA

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The aim of the present immunohistochemical study is to determine the metachromatic, tryptase and ghrelin positive mast cells in pulmonary pleura of male rats at different ages. The detection on serial sections of tryptase and ghrelin immunoreactivity with metachromasy allowed us to estimate the number of these three types of cells in lung pleura of different aged male rats. We revealed that the amount of toluidine blue positive mast cells (MCTB) in the lung pleura was significantly less than that of tryptase (MCTr) and ghrelin positive mast cells (GhrMC). The number of tryptase and ghrelin positive mast cells showed similar values. In the comparative study on serial sections, we observed that some MCTr and GhrMC did not show metachromasia. In pleura's subserous layer the percentage of MCTr and GhrMC with manifested metachromasia varies in the different age groups: 58-59% in 1-year-old, 42% in 3-month-old and 20% in 20-day-old animals.

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“…Deletion of SST in multiple endocrine neoplasia type 1 (MEN-1) null mice caused hypergastrinemia and gastric carcinoids ( 35 ). After 12 ws-15% fructose in drinking, SST-D-cells were diminished in gastric corpus and increased in the antrum in male-Wistar rats ( 36 ). C-X-C motif chemokine ligand-14 (CXCL14) immunostaining endocrine cells and SST + cell and nerve fibers co-expressed at the lamina propria and submucosal and muscular layer from the stomach to rectum in mice ( 37 ).…”

Section: Sst-enteric Endocrine Cells and Nervous System In The Gastromentioning

confidence: 99%

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

Shamsi¹,

Chatoo²,

Xu³

et al. 2021

Front. Endocrinol.

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Somatostatin (SST) and somatostatin receptors (SSTRs) play an important role in the brain and gastrointestinal (GI) system. SST is produced in various organs and cells, and the inhibitory function of somatostatin-containing cells is involved in a range of physiological functions and pathological modifications. The GI system is the largest endocrine organ for digestion and absorption, SST-endocrine cells and neurons in the GI system are a critical effecter to maintain homeostasis via SSTRs 1-5 and co-receptors, while SST-SSTRs are involved in chemo-sensory, mucus, and hormone secretion, motility, inflammation response, itch, and pain via the autocrine, paracrine, endocrine, and exoendocrine pathways. It is also a power inhibitor for tumor cell proliferation, severe inflammation, and post-operation complications, and is a first-line anti-cancer drug in clinical practice. This mini review focuses on the current function of producing SST endocrine cells and local neurons SST-SSTRs in the GI system, discusses new development prognostic markers, phosphate-specific antibodies, and molecular imaging emerging in diagnostics and therapy, and summarizes the mechanism of the SST family in basic research and clinical practice. Understanding of endocrines and neuroendocrines in SST-SSTRs in GI will provide an insight into advanced medicine in basic and clinical research.

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Fructose-induced metabolic disturbances in rats and its impact on stomach endocrine cell number and smooth muscle contractility

Cited by 4 publications

References 42 publications

The effect of fructose–induced metabolic syndrome on the histological structure and enteroendocrine cells in duodenum of rats

The effect of fructose–induced metabolic syndrome on the histological structure and enteroendocrine cells in duodenum of rats

Mast Cells in Rat Pulmonary Pleura

Versatile Functions of Somatostatin and Somatostatin Receptors in the Gastrointestinal System

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