Fructus mori polysaccharide alleviates diabetic symptoms by regulating intestinal microbiota and intestinal barrier against TLR4/NF-κB pathway

Chen, Xiaoxia; Wu, Junlin; Fu, Xiong; Wang, Pingping; Chen, Chun

doi:10.1016/j.ijbiomac.2023.126038

Cited by 29 publications

(5 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The study underscores the crucial function of the intestinal barrier’s physical structure, especially the role of tight junction proteins (Occludin and Claudin-1). Disruption in the levels of these proteins, as observed in the CLP group, was linked to heightened intestinal permeability and inflammation ( 22 ). DcR3 administration reversed these effects, as evidenced in Fig.…”

Section: Resultsmentioning

confidence: 99%

Inhibitory mechanisms of decoy receptor 3 in cecal ligation and puncture-induced sepsis

Su,

Chen,

Zhou

et al. 2024

mBio

View full text Add to dashboard Cite

Despite its high mortality, specific and effective drugs for sepsis are lacking. Decoy receptor 3 (DcR3) is a potential biomarker for the progression of inflammatory diseases. The recombinant human DcR3-Fc chimera protein (DcR3.Fc) suppresses inflammatory responses in mice with sepsis, which is critical for improving survival. The Fc region can exert detrimental effects on the patient, and endogenous peptides are highly conducive to clinical application. However, the mechanisms underlying the effects of DcR3 on sepsis are unknown. Herein, we aimed to demonstrate that DcR3 may be beneficial in treating sepsis and investigated its mechanism of action. Recombinant DcR3 was obtained in vitro . Postoperative DcR3 treatment was performed in mouse models of lipopolysaccharide- and cecal ligation and puncture (CLP)-induced sepsis, and their underlying molecular mechanisms were explored. DcR3 inhibited sustained excessive inflammation in vitro , increased the survival rate, reduced the proinflammatory cytokine levels, changed the circulating immune cell composition, regulated the gut microbiota, and induced short-chain fatty acid synthesis in vivo . Thus, DcR3 protects against CLP-induced sepsis by inhibiting the inflammatory response and apoptosis. Our study provides valuable insights into the molecular mechanisms associated with the protective effects of DcR3 against sepsis, paving the way for future clinical studies. IMPORTANCE Sepsis affects millions of hospitalized patients worldwide each year, but there are no sepsis-specific drugs, which makes sepsis therapies urgently needed. Suppression of excessive inflammatory responses is important for improving the survival of patients with sepsis. Our results demonstrate that DcR3 ameliorates sepsis in mice by attenuating systematic inflammation and modulating gut microbiota, and unveil the molecular mechanism underlying its anti-inflammatory effect.

show abstract

Section: Resultsmentioning

confidence: 99%

Inhibitory mechanisms of decoy receptor 3 in cecal ligation and puncture-induced sepsis

Su,

Chen,

Zhou

et al. 2024

mBio

View full text Add to dashboard Cite

show abstract

“…This inflammatory response may be attributed to the stimulation of intestinal cells by ionizing radiation, activating the NF-κB pathway and triggering the release of TNF-α, IL-1β, and IL-6, thereby provoking inflammation in intestinal epithelial cells. 37,38 With the administration of varying doses of TMP, a notable decrease in the expression levels of inflammatory factors in the ileum was observed, indicating the regulatory effect of TMP on radiation-induced intestinal injury in mice. With the molecular weight size of TMP falling within the range of 100 Da to 900 Da (Table 1), we hypothesize that the peptide may directly be absorbed and utilized by intestinal cells.…”

Section: Discussionmentioning

confidence: 97%

Study on the mechanism of mitigating radiation damage by improving the hematopoietic system and intestinal barrier with Tenebrio molitor peptides

Shang,

Cui,

Chen

et al. 2024

Food Funct.

View full text Add to dashboard Cite

show abstract

“…Furthermore, the study reported that MFPs can protect the integrity of the intestinal mucosal barrier through mediating the gut microbiota, alleviating endotoxemia, and ameliorating intestinal inflammation and oxidative damage. 88 As stated in reports, α-amylase and α-glucosidase are the main enzymes affecting postprandial hyperglycaemia, which means that inhibition of the activities of these two enzymes can reduce postprandial blood glucose levels and also prevent type 2 diabetes mellitus. 89 It was also found that MFPs reduced the activities of α-glucosidase and α-amylase by up to 61.83% and 73.27%, respectively.…”

Section: Reviewmentioning

confidence: 99%

Extraction, purification, structural modification, activities and application of polysaccharides from different parts of mulberry

Wang,

Huang

2024

Food Funct.

View full text Add to dashboard Cite

show abstract

Fructus mori polysaccharide alleviates diabetic symptoms by regulating intestinal microbiota and intestinal barrier against TLR4/NF-κB pathway

Cited by 29 publications

References 40 publications

Inhibitory mechanisms of decoy receptor 3 in cecal ligation and puncture-induced sepsis

Inhibitory mechanisms of decoy receptor 3 in cecal ligation and puncture-induced sepsis

Study on the mechanism of mitigating radiation damage by improving the hematopoietic system and intestinal barrier with Tenebrio molitor peptides

Extraction, purification, structural modification, activities and application of polysaccharides from different parts of mulberry

Contact Info

Product

Resources

About