Fruit Extract of Emblica Officinalis (Amla) Protects Radiation Induced Biochemical Lesions In The Brain of Swiss Albino Mice

Singh, Inder Pal; Sharma, Abhilasha; Jindal, Archana; Soyal, Dhanraj; Goyal, P K

doi:10.5214/ans.0972.7531.2006.130302

Cited by 10 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may be due to antioxidants present in EOE which help in decreasing the genotoxicity created by toxicant and also inhibit mutagenesis and carcinogenesis 19,36 . These are in accordance with studies which come to the fact that the imbalance in antioxidant status in the cells as a result of ionizing may be ameliorated as result of administration of EOE 25,37 . EOE significantly restored the antioxidant enzymes Superoxide Dismutase (SOD), Glutathione Peroxidase (GSHPx), and Glutathione Reductase (GR); Reduced Glutathione (GSH); and decreased levels of the lipid peroxide Malondialdehyde (MDA) in hypertensive patients 38, 39 .…”

Section: Fig 3: After 4-days Of Cadmium Chloride Treatment Illustratsupporting

confidence: 91%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

ABSTRACT:In the present study an attempt has been made to explore radiation and cadmium induced histological alterations in mice liver and their modulation by Emblica officinalis fruit Extract (EOE). For this purpose mice were selected from Inbred colony and divided into five different groups. Group: Ι (Sham-irradiated group) considered as normal; II (cadmium chloride treated group) in this group animals were administered 20 ppm cadmium chloride orally as drinking water; III (irradiated group) animals were exposed to 3.5 Gy gamma radiation; IV (Both radiation and cadmium treated group); V (Radiation, cadmium and Emblica treated group) in this group animals were given 1000 mg/kg body wt/animal/day EOE continuously for seven consecutive days, prior to radiation and cadmium chloride treatment and on the 7 th day animals were irradiated after 30 minutes of extract administration. The animals from the above groups were autopsied by cervical dislocation after 1, 2, 4, 7, 14 and 28 days and liver were removed and prepared for light microscopy. The liver cells of irradiated and cadmium treated group showed granular vacuolar cytoplasm with pyknotic and crenated nuclei, moderate dilation with most of the compacted hepatocytes, large area of cellular infiltration and hyperaemia of liver sinusoid. In the EOE treated group, the majority of hepatocytes returned normal, although some had still mild changes. After combined treatment of radiation and cadmium the changes were more severe showing synergistic effect. An early and fast recovery was also noticed in the EOE treated animals which may be due to the protection by drug.

show abstract

Section: Fig 3: After 4-days Of Cadmium Chloride Treatment Illustratsupporting

confidence: 91%

Untitled

2016

IJPSR

View full text Add to dashboard Cite

show abstract

“…This body weight gain might be due to the hepatoprotecting activity resulting in the improvement in the liver function (Pande and Zeestress 2000 ; Babu et al 2002 ; Ratankumar et al 2004 ). According to Singh et al ( 2006 ), Emblica officinalis showed a recovery effect in body weight until 30 days of post-irradiation treatment.…”

Section: Discussionmentioning

confidence: 99%

Emblica officinalis Garten fruits extract ameliorates reproductive injury and oxidative testicular toxicity induced by chlorpyrifos in male rats

Dutta

Sahu

2013

SpringerPlus

View full text Add to dashboard Cite

Organophosphate pesticides have destroying properties on male reproduction and chlorpyrifos adversely affects the male reproductive system. Emblica offcinalis Garten plays a vital role to challenge many diseases in human body. We investigated the induction of oxidative stress in the male reproductive system of adult rats (Wistar Strain) exposed to widely used organophosphate pesticide, Chlorpyrifos, and tried to establish the ameliorative properties of Emblica officinalis Garten with respect to reproductive reconstruction in them. Rats were divided into 2 groups, control group and experimental group, and the experimental group was divided into 3 groups (G1-G3). All the groups had 5 rats each. Control group received water, experimental group, G1, received 20 mg/kg bw/day Emblica officinalis Garten, G2 received 12 mg/kg bw/day chlorpyrifos and G3 received 12 mg chlorpyrifos with 20 mg Emblica officinalis Garten /kg bw/day. Treatment was done orally from 30 days. Thereafter body weight, male reproductive organs weight, sperm count, sperm morphology, ACP, ALP, total protein, uric acid and testis and serum testosterone level were determined using standard methods. The changes recorded are indicative of infertility in male rats because of chlorpyrifos exposure. When the subjects were treated with Emblica officinalis Garten in conjunction with chlorpyrifos, these parameters exhibited recovery and when treated with Emblica officinalis Garten alone, these parameters were more or less near to the control group. This highlights the debilitating effect of chlorpyrifos and scavenging property of Emblica officinalis Garten.Electronic supplementary materialThe online version of this article (doi:10.1186/2193-1801-2-541) contains supplementary material, which is available to authorized users.

show abstract

“…The bitter tonic which is obtained from the rhizomes of N. Jatamansi (Bhutajata, Jathilaa, Thapaswini) can be used as a neuroprotective, sunscreen, stimulant, antispasmodic, repellent, antipyretic and antioxidant, as well as to treat the Herpes infection, leprosy, various neuropsychiatric illnesses, and excessive thirst [18,19]. Some plants like Santalum album [20], Embelia ribes [21], Piper longum, Zinger officinale, Syzygium aromaticum, Elettaria cardamum [22], Rubia cordifolia [23], Ocimum sanctum [24], Asparagus racemosus, Glycorrhiza glabra, Phyllanthus embelica, Boerrhaavia diffusa and Eclipta alba have been found to possess antioxidant properties [25] and some of them have proved to be radioprotective.…”

Section: Haematological Parametersmentioning

confidence: 99%