Fruit of the jambolan tree (Eugenia jambolana Lam.) and experimental diabetes

Pepato, Maria Teresa; Mori, Daniela M.; Baviera, Amanda Martins; Harami, J. B.; Vendramini, Regina Célia; Brunetti, Iguatemy Lourenço

doi:10.1016/j.jep.2004.07.029

Cited by 87 publications

(61 citation statements)

References 21 publications

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“…92 However, in a Brazilian study, treatment of streptozotocin-induced diabetic rats with the lyophilized fruit pulp extract of Jamun was unable to reduce the raised blood sugar levels. 93 The effect of aqueous and ethanol extracts of Jamun fruit pulp was studied in the alloxan-induced diabetic rats and both extracts Jagetia GC. Pharmacological activities of Jamun, Syzygium Cumini J Explor Res Pharmacol were found to alleviate the blood glucose level, but the aqueous extract was more potent than the ethanol extract.…”

Section: Antidiabetic Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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Section: Antidiabetic Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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“…use non-conventional therapies for the treatment of diseases, including medicinal herbs. In Brazil, it is clear that the treatment of diseases with the infusion of plants and cooking is a common practice despite the lack of statistical data on the subject (PEPATO et al, 2005).…”

Section: Preparation Of Dietsmentioning

confidence: 99%

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

Salgado¹,

Bombarde²,

Mansi³

et al. 2010

Ciênc. Tecnol. Aliment.

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“…(Hussein et al, 2003), a pitangueira (E. unifl ora L.) (Auricchio;Bacchi, 2003), o jambolão (E. jambolana Lam.) (Alberton et al, 2001;Pepato et al, 2005) e o cravo da Índia (E. caryophyllata Thunb.) (Corrêa, 1984;Kelecom et al, 2002).…”

Section: Introductionunclassified

Estudo fitoquímico e avaliação das atividades moluscicida e larvicida dos extratos da casca do caule e folha de Eugenia malaccensis L. (Myrtaceae)

Oliveira¹,

Humberto²,

Silva³

et al. 2006

Rev. bras. farmacogn.

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RESUMO:Eugenia malaccensis L. (Syzygium malaccensis Merr.& Perry), denominada comumente de jambo vermelho, é uma espécie arbórea de ocorrência comum no Brasil e faz parte das plantas medicinais do Estado de Alagoas. Estudos químicos anteriores com E. malaccensis foram realizados com plantas coletadas na Ásia, Oceania e na América Central. Este trabalho descreve o estudo químico do extrato etanólico das folhas e cascas de um espécimem coletado no Estado de Alagoas, Brasil. Considerando-se a escassa literatura sobre o potencial moluscicida e larvicida dessa espécie, buscou-se testar estas atividades contra caramujos Biomphalaria glabrata Say, e frente às larvas do mosquito Aedes aegypti L. Os extratos etanólicos da casca do caule e das folhas foram inativos frente às larvas de Aedes aegypti na concentração de 500 μg/mL, porém, ativos contra Biomphalaria glabrata (CL 50 = 42,53 e 41,90 μg/mL, respectivamente). O estudo químico levou ao isolamento e identifi cação de 5,7,3',4',5'-penta-hidroxi-fl avonol (1), 5,7,3',5'-tetra-hidroxi-4'-metoxi-fl avonol (2), ácido 3,4,5-tri-hidroxibenzóico (3) e ácido 3-acetil-urs-12-en-28-óico (4) das folhas e da casca do caule. O composto 4 é isolado pela primeira vez no gênero Eugenia. As estruturas desses compostos foram estabelecidas através de estudos no IV, de RMN 1 H e 13 C e comparação com dados da literatura. Considering that studies on the molluscicidal and larvicidal potential of E. malaccensis were not reported, this work aimed to test its molluscicidal activity against Biomphalaria glabrata snails and larvicidal activity against Aedes aegypti mosquitos. The ethanolic stem bark and leaf extracts were inactive towards Aedes aegypti larvae. The ethanolic stem bark and leaf extract were active against Biomphalaria glabrata with CL 50 = 42.53 and 41.90 μg/mL, respectively. 5,7,3',4',5'-Penta-hydroxy-fl avonol (1), 5,7,3',5'-tetra-hydroxy-4'-methoxyfl avonol (2), 3,4,5-tri-hydroxybenzoic acid (3) and 3-acetyl-urs-12-en-28-oic acid (4) were isolated and identifi ed from the leaves and stem bark. The acid 3β-O-acetyl-urs-12-en-28-oic is for the fi rst time isolated from the genus Eugenia. The structures of the compounds have been established by IR, 1 H and 13 C NMR spectral analysis and by comparison with literature data.

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Fruit of the jambolan tree (Eugenia jambolana Lam.) and experimental diabetes

Cited by 87 publications

References 21 publications

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Effects of different concentrations of passion fruit peel (Passiflora edulis) on the glicemic control in diabetic rat

Estudo fitoquímico e avaliação das atividades moluscicida e larvicida dos extratos da casca do caule e folha de Eugenia malaccensis L. (Myrtaceae)

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