Post-harvest physiological disorders in citrus fruit crops (Citrus spp.) present significant challenges that impact both the economic and environmental aspects of global agriculture. This comprehensive review explored various dimensions of the subject, ranging from the description and classification of major disorders, such as chilling injury, rind staining, water loss, and mold, to the innovative detection and diagnostic techniques being employed in the industry. Through an extensive examination of prevention and management strategies, the review sheds light on pre-harvest factors, post-harvest treatments, and the role of modern technologies and agronomic practices in mitigating these disorders. It also delves into the economic losses and environmental consequences linked to different management approaches, underlining the need for sustainability and eco-friendly solutions. A particular focus is given to the emerging trends and technologies in the field, including nanotechnology, artificial intelligence, and natural treatments, all of which signal a shift towards a more integrated and sustainable management approach. By identifying current research gaps and the necessary future research direction, the review highlights opportunities for innovation and collaboration among growers, researchers, and policymakers. In addition, it emphasizes the broader implications of these disorders and their management on global trade, labor markets, and regulatory landscapes. This review serves as a valuable reference for stakeholders in the citrus industry, providing insights and guidance on best practices, technological advancements, and future perspectives. It represents an essential step towards aligning the citrus production with global sustainability goals and fostering a resilient industry capable of adapting to the ever-changing demands and challenges of the modern world.