We investigate interacting ghost dark energy models in higher dimensional cosmology. We attempt to model dark matter within a barotropic fluid with P b = ω(t) b ρ. In this work we consider four different models based on choosing equation of state parameter and interaction term. We confirm that our models agree with observational data. cosmological constant introduced by Einstein. This model has fine-tuning and coincidence problems. Absence of a fundamental mechanism which sets the cosmological constant zero or very small value makes researchers to go deeper and deeper in theories to understand the solution of these problems. In order to alleviate these problems alternative models of dark energy suggest a dynamical form of dark energy, which at least in an effective level, can originate from a variable cosmological constant [6,7], or from various fields, such as a quintessence [8][9][10], a phantom field [11][12][13][14][15], or the combination of quintessence and phantom in a unified model named quintom [16][17][18][19][20]. By using some basic of quantum gravitational principles one can formulate several other models for dark energy, and in literature they are known as holographic dark energy models [21][22][23][24][25] and agegraphic dark energy models [26][27][28]. Interaction between components is proved to be other way which can solve coincidence problem. From observations no piece of evidence has been so far presented against interactions between dark energy and dark matter. From theoretical side we have not any known symmetry which prevents or suppresses a non-minimal coupling between dark energy and dark matter. Research in theoretical cosmology proposes two possible ways to explain later time accelerated expansion of the Universe. Remember that field equations make connection between geometry and matter content of Universe in a simple way. Therefore, there is two possibilities either we should modify matter content which is coded in energy-stress tensor or we should modify geometrical part including different functions of Ricci scalar etc. Different type of couplings between geometry and matter could give desirable effects as well. Recently, several authors try to make connection between scalar field and other models of dark energy. In literature, often used idea of fluid despite to other ideas, because over the years we learned that modifications of geometrical part of field equations can be codded in fluid expression. Chaplygin gas and its extensions [29][30][31][32][33][34][35][36][37][38][39][40] are interesting models based of the above idea. This model is more appropriate choice to have constant negative pressure at low energy density and high pressure at high energy density. Among various models of dark energy, a new model is called Veneziano ghost dark energy, has attracted a lot of interests in recent years [41][42][43][44][45][46][47]. Indeed, the contribution of the ghosts field to the vacuum energy in curved space or time-dependent backgrounds can regarded as a possible candidate for the dark...