FTY720 in combination with cyclosporine—an analysis of skin allograft survival and renal function

Evaluation of stem cell administration in a model of kidney ischemia-reperfusion injury

“…FTY720 prevents acute rejection without causing renal toxicity [15,16] and could be therefore an exciting candidate for immunosuppression after kidney transplantation. Moreover, FTY720 has been shown to improve kidney recovery after IR in rodents [11][12][13][14].…”

“…In animal models of renal toxicity, FTY720 (1 mg/kg/day) administered during 21 days alone or in association with Cyclosporine (CsA) did not cause significant changes in renal structure and function [15]. Moreover, FTY720 administration (1 mg/kg/day) increased mice skin allograft survival in a fully mismatched strain combination [16] suggesting that its use in transplantation could prevent rejection, avoid renal toxicity and improve kidney recovery from IR injury.…”

Changes in lymphocyte phenotype and increased skin allograft survival after FTY720+FK506 therapy

“…It has been shown that FTY720+CsA improve skin allograft survival in a fully mismatched strain combination without causing important changes in kidney function and structure. 24 These results suggest that FTY720 can be associated to CNIs at least for a short period of time without causing enhanced kidney side effects.…”

“…24 However, it has been shown that some patients might not be submitted to CsA continuous administration due to toxicity and/or other side effects. In such cases, FK506 is a candidate for CsA substitution due its immunosuppressive potential.…”

Expression of MHC-I mRNA in Peripheral Blood Lymphocytes as an Early Marker of Acute Rejection Following Skin Transplantation in Mice

“…Skin grafts were scored twice daily. Each graft was considered rejected when 60% or more of the graft tissue was destroyed (Silva et al 2006), by the macroscopic appearance of graft necrosis, followed by histopathological confirmation.…”