Fubrick tea attenuates high-fat diet induced fat deposition and metabolic disorder by regulating gut microbiota and caffeine metabolism

Jing, Nana; Liu, Xiaoxia; Jin, Mingliang; Yang, Xingbin; Hu, Xin; Li, Caiyan; Zhao, Ke

doi:10.1039/d0fo01282c

Cited by 64 publications

(46 citation statements)

References 84 publications

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“…Our results indicated that a high-fat model was successfully established by feeding SD rats with a high-fat diet for four consecutive weeks. In the present study, the increase in serum and liver lipid levels in rats fed a high-fat diet was consistent with other studies [ 8 , 50 , 51 ]. However, the serum and liver lipid levels of HFD rats supplemented with walnut meal peptides were restored to levels close to those of ND rats.…”

Section: Discussionsupporting

confidence: 93%

Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

et al. 2021

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As a natural active substance that can effectively improve blood lipid balance in the body, hypolipidemic active peptides have attracted the attention of scholars. In this study, the effect of walnut meal peptides (WMP) on lipid metabolism was investigated in rats fed a high-fat diet (HFD). The experimental results show that feeding walnut meal peptides counteracted the high-fat diet-induced increase in body, liver and epididymal fat weight, and reduce the serum concentrations of total cholesterol, triglycerides, and LDL-cholesterol and hepatic cholesterol and triglyceride content. Walnut meal peptides also resulted in increased HDL-cholesterol while reducing the atherosclerosis index (AI). Additionally, the stained pathological sections of the liver showed that the walnut meal peptides reduced hepatic steatosis and damage caused by HFD. Furthermore, walnut meal peptide supplementation was associated with normalization of elevated apolipoprotein (Apo)-B and reduced Apo-A1 induced by the high-fat diet and with favorable changes in the expression of genes related to lipid metabolism (LCAT, CYP7A1, HMGR, FAS). The results indicate that walnut meal peptides can effectively prevent the harmful effects of a high-fat diet on body weight, lipid metabolism and liver fat content in rats, and provide, and provide a reference for the further development of walnut meal functional foods.

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Section: Discussionsupporting

confidence: 93%

Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

et al. 2021

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“…Previously reported, the abundance of Parabacteroides was signi cantly decreased in obese subjects with metabolic syndrome [6], and nonalcoholic fatty liver disease [25], and negatively correlated with weight gain and leptin plasma levels [26]. And germane to our ndings, both genera Gemmiger [27] and Parabacteroides [28] are gut bacteria negatively associated with obesity and disturbed host metabolism. In accordance, we found that that the fecal abundance of these bacteria was signi cantly higher in the MHO group compared with MUO.…”

Section: Discussionsupporting

confidence: 78%

The Role of the Gut Microbiota on the Metabolic Status of Obese Children

Yuan

Chen

McCormick

et al. 2021

Preprint

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Background The term “metabolically healthy obese (MHO)” denotes a hale and salutary status, yet this connotation has not been validated in children, and may, in fact, be a misnomer. As pertains to obesity, the gut microbiota has garnered attention as conceivably a nosogenic or, on the other hand, protective participator.Objective This study explored the characteristics of the fecal microbiota of obese Chinese children and adolescents of disparate metabolic statuses, and the associations between their gut microbiota and circulating proinflammatory factors, such as IL-6, TNF-α, lipopolysaccharide-binding protein (LBP), and a cytokine up-regulator and mediator, leptin. Results Based on weight and metabolic status, the 86 Chinese children (ages 5-15 years) were divided into three groups: metabolically healthy obese (MHO, n=42), metabolic unhealthy obese (MUO, n=23), and healthy normal weight controls (Con, n=21). In the MUO subjects, the phylum Tenericutes, as well as the alpha and beta diversity, were significantly reduced compared with the controls. Furthermore, Phylum Synergistetes and genus Bacteroides were more prevalent in the MHO population compared with controls. For the MHO group, Spearman’s correlation analysis revealed that serum IL-6 positively correlated with genus Paraprevotella, LBP was positively correlated with genus Roseburia and Faecalibacterium, and negatively correlated with genus Lactobacillus, and leptin correlated positively with genus Phascolarctobacterium and negatively with genus Dialister (all p<0.05).Conclusion Although there are distinct differences in the characteristic gut microbiota of the MUO population versus MHO, dysbiosis of gut microsystem is already extant in the MHO cohort. The abundance of some metabolism-related bacteria associates with the degree of circulating inflammatory compounds, suggesting that dysbiosis of gut microbiota, present in the MHO children, conceivably serves as a compensatory or remedial response to a surfeit of nutrients.

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“…Ruminococcus_torques_groupis a genera derived from genus Mediterraneibacter from the family Lachnospiraceae (NCBI Taxonomy Browser, https://www.ncbi.nlm.nih.gov/ Taxonomy/Browser/wwwtax.cgi) and was discovered to ferment gastric mucins and identified as a butyrate-producing bacterium (41). A study on Fubrick tea aqueous extract (FTEs) in mice indicated that FTEs were able to alleviate visceral fat deposition via an increase in the abundance of Lachnospiraceae (42). This result suggests a positive correlation between fat deposition and Lachnospiraceae abundance.…”

Section: Discussionmentioning

confidence: 99%

Cecal Microbiota Modulates Fat Deposition in Muscovy Ducks

Lyu

Liu

et al. 2021

Front. Vet. Sci.

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Ducks with the same genetic background vary greatly in their adiposity phenotypes. The gut microbiota plays an essential role in host physiological development and metabolism including fat deposition. However, the association of the gut microbiota with the lipogenic phenotype of ducks remains unknown. In this study, we investigated the cecal microbiota of adult Muscovy ducks and the correlation of the cecal microbiota with fat phenotypes. A total of 200 Muscovy ducks were selected from a population of 5,000 Muscovy ducks to record their abdominal fat weight and collect their cecal contents after being slaughtered and defeathered. The cecal contents were subjective to DNA isolation and 16S rRNA gene sequencing. The results were sorted according to the percentage of abdominal fat and the top 20% (n = 40) and the bottom 20% (n = 40) were set as the high and low groups, respectively. Our results indicated that in the cecum of Muscovy ducks, Bacteroidetes, Firmicutes, and Fusobacteria were the predominant phyla while Bacteroides, Oscillospiraceae_uncultured, Parabacteroides, and Bacteroidales_norank were the top 4 dominant genera. Abdominal fat weight (18.57~138.10 g) and percentage of abdominal fat (1.02~27.12%) were significantly correlated (R2 = 0.92, P < 0.001). Although the lipogenic phenotypes of ducks had a significant difference (P < 0.05), the α-diversities of the high and low groups were not significantly different (P > 0.05). Nevertheless, after random forest analysis, we identified two genera, Treponema and Ruminococcus_torques_group, that were significantly associated with fat deposition in Muscovy ducks. In addition, the abundances of Treponema and Ruminococcus_torques_group gave a significantly negative and positive association with abdominal fat weight, respectively (P < 0.05). Ducks with a low level of Treponema exhibited a tendency toward a high percentage of abdominal fat (P < 0.01), while the percentage of abdominal fat in ducks with high Ruminococcus_torques_group abundance tended to be higher than that in ducks with low Ruminococcus_torques_group abundance (P < 0.01). These findings could provide the basic data on the cecal microbiota in Muscovy ducks as well as a theoretical foundation to limit the fat deposition by modulating the gut microbiota in the duck industry.

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Fubrick tea attenuates high-fat diet induced fat deposition and metabolic disorder by regulating gut microbiota and caffeine metabolism

Abstract: Fubrick tea aqueous extract (FTEs) improved lipid metabolism by regulating gut microbiota and caffeine metabolism in high-fat diet induced obese mice.

Cited by 64 publications

References 84 publications

Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

The Role of the Gut Microbiota on the Metabolic Status of Obese Children

Cecal Microbiota Modulates Fat Deposition in Muscovy Ducks

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