2022
DOI: 10.3389/fimmu.2022.929138
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Fucose as a potential therapeutic molecule against the immune-mediated inflammation in IgA nepharopathy: An unrevealed link

Abstract: BackgroundIgA nephropathy (IgAN) is an autoimmune disease that affects people of any age and is an important cause of end-stage renal disease. However, the pathogenesis and pathophysiology of IgAN is not clear. This article aimed to explore the immune-mediated inflammation and genetic mechanisms in IgAN.MethodsThe transcriptome sequencing data of IgAN glomeruli in the Gene Expression Omnibus database were downloaded. Single-sample gene set enrichment analysis was used to estimate the immune microenvironment of… Show more

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Cited by 7 publications
(4 citation statements)
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“…However, at the present time, its exogenous administration was also identified via a neural network model using the Drug Signatures Database as a candidate for treating severe inflammation in IgAN by reducing the deposition of complement C3 [ 44 ], and its administration was also found to alleviate intestinal epithelial damage via upregulating FUT2, impeding oxidative stress, mitochondrial dysfunction, and cell apoptosis [ 45 ]. In kidney transplants, it has been studied as a decoy molecule, significantly reducing ischemia reperfusion injury [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…However, at the present time, its exogenous administration was also identified via a neural network model using the Drug Signatures Database as a candidate for treating severe inflammation in IgAN by reducing the deposition of complement C3 [ 44 ], and its administration was also found to alleviate intestinal epithelial damage via upregulating FUT2, impeding oxidative stress, mitochondrial dysfunction, and cell apoptosis [ 45 ]. In kidney transplants, it has been studied as a decoy molecule, significantly reducing ischemia reperfusion injury [ 46 ].…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, the results were visualized using Cytoscape software. We used the Enrichr platform (https://amp.pharm.mssm.edu/ Enrichr/) (18) to access the DSigDB database (19) for potential drug prediction.…”
Section: Regulatory Network Construction and Potential Drug Predictionmentioning
confidence: 99%
“…On the host side, fucosylation may modulate antitumor immunity and, therefore, could be considered as one of the immunotherapeutic approaches in the treatment of cancer ( Adhikari et al 2022 ). Fucose itself could be also considered as a potential therapeutic molecule in autoimmune diseases with the immune-mediated inflammation such as IgA nephropathy ( Qing et al 2022 ). L-fucose treatment ameliorates DSS-induced colonic inflammation and intestinal epithelial injury via accelerating the proliferation of intestinal stem cells ( Tan et al 2022 ).…”
Section: Mucosal Surfacesmentioning
confidence: 99%