Fucosylation of serum glycoproteins in lung cancer patients

Kossowska, Barbara; Ferens-Sieczkowska, Mirosława; Gancarz, Roman; Passowicz−Muszyńska, Ewa; Jankowska, Renata

doi:10.1515/cclm.2005.066

Cited by 45 publications

(39 citation statements)

References 9 publications

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“…groups. In harmony with this current study, Kossowska et al (2005) showed that fucosylated oligosaccharides are specific markers for inflammation and tumorigenesis and previous clinico-pathological studies of colorectal and lung cancer patients as well as experimental models of these cancer cells indicated that increase in fucosylated residues promote metastatic potential and indicate poor prognosis which explained its higher level in 16 and 18 weeks p.i groups.…”

Section: Discussionsupporting

confidence: 88%

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Soliman¹,

Keshk²,

Shoheib³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted upon 80 mice that were divided the control group (10 non infected mice) and infected group which was subdivided into 7 sub-groups (10 mice each) according to the time of sacrifaction in the post infection (p.i.) period, 10 mice being sacrificed every two weeks from 6 weeks p.i. to 18 weeks p.i. Tumor necrosis factor alpha (TNF-α), inducible nitric oxide synthase (iNOS), and pentraxin 3 (PTX3) levels were estimated by immunoassay. The L-fucose level, and thioredoxin reductase (TrxR) and lactate dehydrogenase (LDH) activities were also evaluated in colonic tissue. Results: The current study revealed statistically significant elevation in the studied biochemical markers especially at 16 and 18 weeks p.i. The results were confirmed by histopathological examination that revealed atypical architectural and cytological changes in the form of epithelial surface serration and nuclear hyper-chromatizia at 14, 16 and 18 weeks p.i. Conclusions: inflammation, oxidative stress and L-fucose together may form an important link between Schistosomal mansoni infection and colonic dysplasia and they can be new tools for prediction of colonic dysplasia development in experimental schistosomiasis.

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Section: Discussionsupporting

confidence: 88%

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Soliman¹,

Keshk²,

Shoheib³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…30,[36][37][38][39][40] Over-expression of haptoglobin, and changes in the level of fucose and/or sialic acid residues, are common themes emerging from all these studies, but no cancer-specific glycoform of haptoglobin has been found to date. Our studies of prostate cancer haptoglobin have opened up 2 new avenues for investigation.…”

Section: Discussionmentioning

confidence: 99%

Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects

Fujimura

Shinohara

Tissot

et al. 2007

Intl Journal of Cancer

114

115

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We studied chemical level and glycosylation status of haptoglobin in sera of patients with prostate cancer, as compared to benign prostate disease and normal subjects, with the following results. (i) Haptoglobin level was enhanced significantly in sera of prostate cancer. (ii) Sialylated bi-antennary glycans were the dominant structures in haptoglobins from all 3 sources, regardless of different site of N-linked glycan. The N-linked glycans at N184 were exclusively bi-antennary, and showed no difference between prostate cancer vs. benign prostate disease. (iii) Tri-antennary, N-linked, fucosylated glycans, carrying at least 1 sialyl-Lewis x/a antenna, were predominantly located on N207 or N211 within the amino acid 203-215 sequence of the b-chain of prostate cancer, and were minimal in benign prostate disease. Fucosylated glycans were not observed in normal subjects. A minor tri-antennary N-linked glycan was observed at N241 of the b-chain in prostate cancer, which was absent in benign prostate disease. (iv) None of these N-linked structures showed the expected presence of disialylated antennae with GalNAcb4(NeuAca3)Galb3(NeuAca6)GlcNAcbGal, or its analogue, despite cross-reactivity of prostate cancer haptoglobin with monoclonal antibody RM2. (v) Minor levels of O-glycosylation were identified in prostate cancer haptoglobin for the first time. Monoand disialyl core Type 1 O-linked structures were identified after reductive b-elimination followed by methylation and mass spectrometric analysis. No evidence was found for the presence of specific RM2 or other tumor-associated glycosyl epitopes linked to this Oglycan core. In summary, levels of haptoglobin are enhanced in sera of prostate cancer patients, and the N-glycans attached to a defined peptide region of its b-chain are characterized by enhanced branching as well as antenna fucosylation. ' 2007 Wiley-Liss, Inc.

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“…Moreover, in early pregnancy increasing expression of sialic acid linked α2-3 in the deciduas surrounding the implantation site have been shown to be associated with the implantation of the embryo in the uterus of pregnant rats and mice [25]. The α2-3 (but not α2-6) linked sialic acid glycoconjugates, further modified by α1-3 fucosylation (a Lewis x epitope) are essential ligands for E-, P-, and L-selectin binding in adhesive interactions [20,26,27]. Modifications in sialic acid expression have been shown to occur during development and differentiation of porcine tissues.…”

Section: Discussionmentioning

confidence: 99%

Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age

et al. 2005

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The present knowledge concerning the glycan structures and role of glycoconjugates derived from amniotic fluid is fragmentary and mainly focuses on the individual glycoproteins. The question has arisen as whether the general glycosylation pattern of amniotic fluid glycoconjugates can change with the progression of a normal pregnancy. In the present work we have described the dynamic, quantitative alterations in relative amounts of sialic acid and fucose linked by a variety of anomeric linkages to subterminal oligosaccharide structures of amniotic fluid glycoconjugates in relation to pregnancy age. The analysis was performed in the following groups of amniotic fluids derived from normal pregnancy by lectin dotting method: "2nd trimester" (14-19 weeks), "3rd trimester" (29-37 weeks), "perinatal period" (38-40 weeks) , "delivery at term" (39-41 weeks) and "post date pregnancy" (41-43 weeks). In the "3rd trimester" the amniotic fluid glycoconjugates contained higher relative amounts of glycans terminated by alpha2-6-linked sialic acid (p < 0.00002) and by alpha1-6 innermost fucose (p < 0.000001) than those in the 2nd trimester. In contrast, they showed the lower relative amount of fucose linked alpha1-3 (p < 0.02). At the perinatal period the relative amount of alpha2-6-linked sialic acid increased (p < 0.03), and it then decreased during delivery (p < 0.02) to the level found in the "3rd trimester" group. In the post date pregnancy all parameters studied increased. The sialyl- and fucosyl-glycotopes of the amniotic fluid glycoconjugates may play an critical role in growth and tissue remodeling of the foetus, as well as may might reflect maturation of a foetus. Additionally, a determination of the glycotope expressions might be helpful in prenatal diagnosis as predictor factors for well being of mother and child.

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Fucosylation of serum glycoproteins in lung cancer patients

Cited by 45 publications

References 9 publications

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Glycosylation status of haptoglobin in sera of patients with prostate cancer vs. benign prostate disease or normal subjects

Relative amounts of sialic acid and fucose of amniotic fluid glycoconjugates in relation to pregnancy age

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