Fucoxanthin alleviates methamphetamine-induced neurotoxicity possibly via the inhibition of interaction between Keap1 and Nrf2

Wei, Jiaxin; Mou, Chenye; Bao, Yongjie; Xie, Yuning; Jin, Haixiao; Shen, Haowei; Zhou, Wenhua; Zhang, Jinrong; He, Shan; Chen, Bojun; Liu, Lin; Wu, Xiang; Yan, Xiaojun; Cui, Wei

doi:10.1016/j.jff.2021.104713

Cited by 13 publications

(4 citation statements)

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“…The inhibitory effects of fucoxanthin on Keap1-Nrf2 interaction resulted in activated Nrf2/Keap1/ARE pathway and increased the accumulation of nuclear Nrf2 protein, with a subsequent enhancement in the expression of Nrf2 target genes. Another study showed that fucoxanthin has a high affinity with Keap1, and it promotes the dissociation of the Keap1–Nrf2 complex, enhancing Nrf2 nuclear translocation in rat pheochromocytoma PC12 cells [ 39 ]. According to some studies, fucoxanthinol has been shown to activate the Nrf2/ARE signaling pathway, similar to its precursor, fucoxanthin.…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Neuroprotective Effects of Fucoxanthin and Its Metabolite Fucoxanthinol: A Comparative In Vitro Study

Pruccoli,

Balducci,

Pagliarani

et al. 2024

CIMB

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Fucoxanthin is the most abundant carotenoid found in marine brown algae that exhibits several healthy properties. Dietary fucoxanthin is metabolized in the intestine, plasma, and other tissues to various metabolites, including fucoxanthinol. In this regard, the contribution of fucoxanthinol to the healthy properties of its precursor, fucoxanthin, against pathogenetic events associated with neurodegenerative diseases remains unexplored. Here, we evaluated and compared the antioxidant and neuroprotective effects of the carotenoids fucoxanthin and fucoxanthinol in in vitro models of Alzheimer’s (AD) and Parkinson’s (PD) disease. Neuronal SH-SY5Y cells were used to evaluate the antioxidant properties of the carotenoids against ABTS radical in the membrane and cytoplasm and oxidative stress elicited by tert-butyl hydroperoxide using the 2′,7′-dichlorodihydrofluorescein diacetate probe. We also assessed the ability of the carotenoids to increase the glutathione (GSH) and activate the Nrf2/Keap1/ARE pathway using the monochlorobimane probe and western blotting method, respectively. The neuroprotective effects of the carotenoids against the neurotoxicity generated by oligomers of Beta-Amyloid (1–42) peptide (OAβ) and 6-hydroxydopamine (6-OHDA), which are neurotoxins of AD and PD, respectively, were finally evaluated in the same neuronal cells using the thiazolyl blue tetrazolium bromide assay. Both carotenoids could reach the cytoplasm, which explains the mainly free radical scavenging activity at this level. Notably, fucoxanthinol had higher and lower antioxidant activity than fucoxanthin at extracellular and cellular levels. Although studied carotenoids exerted the ability to activate the Nrf2/Keap1/ARE pathway, leading to an increase of intracellular GSH, our results suggested that the antioxidant activity of the carotenoids could be mainly attributed to their radical scavenging activity in neuronal membrane and cytoplasm, where they accumulate. Fucoxanthinol also shared similar neuroprotective effects as fucoxanthin against the neurotoxicity generated by OAβ and 6-OHDA, suggesting a potential neuroprotective contribution to the action of fucoxanthin administered as a food supplement in in vivo experimental models. These results encourage further research to evaluate the bioavailability of fucoxanthinol and other metabolites of fucoxanthin at the brain level to elucidate the dietary neuroprotective potential of fucoxanthin.

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Section: Resultsmentioning

confidence: 99%

Antioxidant and Neuroprotective Effects of Fucoxanthin and Its Metabolite Fucoxanthinol: A Comparative In Vitro Study

Pruccoli,

Balducci,

Pagliarani

et al. 2024

CIMB

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“…Fucoxanthin is a natural orange carotenoid and a typical lipid compound found in edible brown algae and seaweeds. Fucoxanthin belongs to the class of non-pro-vitamin A carotenoids and presents several health benefits, including antioxidant, apoptosis-promoting [ 147 ], anticancer, anti-inflammatory, and antidiabetic effects [ 148 ]. Fucoxanthin plays a crucial role in combating neurodegenerative diseases by decreasing proinflammatory factor production or increasing the neuroprotective expression of BDNF.…”

Section: Resultsmentioning

confidence: 99%

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Liaqat

Parveen

Kim

2022

IJMS

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Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

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“…These findings suggest fucoxanthin could have a role as an antidote to methamphetamine toxicity. 387 A combination of GNPS-molecular networking and bioassay-guided fractionation has shown that individual fatty acids isolated from Saccharina latissima and Laminaria digitata are inactive by themselves, but mixtures were synergistically active against the swine helminth parasite Ascaris suum . 388 Investigation of the phlorotannins and pigments of intertidal rock-pool Sargassaceae algae from Brittany has shown that the smaller, more dense individuals are located in lower pools but with higher levels of biosynthetic pigments to compensate for protection against irradiation, and that phlorotannins did not appear to play a photoprotective role and their content and distribution is more reflective of taxonomy rather than source location.…”

Section: Brown Algaementioning

confidence: 99%

Marine natural products

et al. 2023

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Fucoxanthin alleviates methamphetamine-induced neurotoxicity possibly via the inhibition of interaction between Keap1 and Nrf2

Cited by 13 publications

References 50 publications

Antioxidant and Neuroprotective Effects of Fucoxanthin and Its Metabolite Fucoxanthinol: A Comparative In Vitro Study

Antioxidant and Neuroprotective Effects of Fucoxanthin and Its Metabolite Fucoxanthinol: A Comparative In Vitro Study

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Marine natural products

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