Fucoxanthin and its metabolite, fucoxanthinol, suppress adipocyte differentiation in 3T3-L1 cells

Maeda, Hayato; Hosokawa, Masashi; Sashima, Tokutake; Takahashi, Nobuyuki; Kawada, Teruo; Miyashita, Kazuo

doi:10.3892/ijmm.18.1.147

Cited by 130 publications

(153 citation statements)

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“…Wls rich in fucoxanthin were prepared from dried seaweed powder by acetone extraction. The composition of the Wls was analyzed by high performance liquid chromatography (HPlc) as per previously published methods (15). The extracted Wls mainly consisted of glycolipids (68%), and had a fucoxanthin concentration of 10%.…”

Section: Methodsmentioning

confidence: 99%

“…This suggests that a Wl diet improves insulin resistance, suppressing inflammatory reactions in WAT. Our previous study revealed that fucoxanthin and fucoxanthinol (a metabolized component of fucoxanthin) affect peroxisome proliferator-activated receptor γ (PParγ) and promote gene expression related to lipid metabolism in adipocytes (4,15). Hence, it can be presumed that WLs relieve inflammation in adipose tissue, thus having an anti-diabetic effect.…”

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confidence: 99%

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Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Maeda$^{¹

2009

Mol Med Rep

241

176

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Abstract. Fucoxanthin, a characteristic carotenoid of brown algae, has been reported to exert an anti-diabetic effect in an obese murine model. Wakame (Undaria pinnatifida), an edible seaweed, is rich in fucoxanthin. This study examined the anti-obesity and anti-diabetic effects of fucoxanthin-rich wakame lipids (Wls) on high fat (HF) diet-induced obesity in mice. Mice were fed a high fat control (HF c ) or normal fat control (nF c ) diet for 10 weeks. The HF diet-fed group was administered a HF diet containing Wls for a further 5 weeks. Parameters related to diabetes and obesity conditions were evaluated and compared. The HF-Wl diet, which was rich in fucoxanthin, significantly suppressed body weight and white adipose tissue (WaT) weight gain induced by the HF diet. dietary administration of the HF diet resulted in hyperglycemia, hyperinsulinemia and hyperleptinemia in the mouse model. These perturbations were completely normalized in the HF-Wl diet-fed group. increased expression of monocyte chemoattractant protein-1 (McP-1) mrna expression was observed in HF c mice, but was normalized in the HF-Wl groups. Moreover, the HF-Wl diet promoted mrna expression of β3-adrenergic receptor (adrb3) in WaT and glucose transporter 4 (gluT4) mrna in skeletal muscle tissues. These results suggest that dietary Wls may ameliorate alterations in lipid metabolism and insulin resistance induced by a HF diet. There is therefore a biochemical and nutritional basis for the application of fucoxanthin-rich Wls as a functional food to prevent obesity and diabetes-related disorders. IntroductionThe modern-day tendency to consume nutritionally rich diets coupled with irrational dietary habits create physiological disorders. These lead to the accumulation of visceral fat, and finally result in obesity and related disorders, such as diabetes mellitus, hypertension, dyslipidemia and cardiovascular disease (1,2). long-term consumption of a high fat (HF) diet accelerates the development of obesity (3); hence, strategies to prevent obesity are of great importance. Fucoxanthin is a characteristic carotenoid of brown algae including edible species such as Undaria pinnatifida and Hijikia fusiformis. We recently reported the suppression of the development of white adipose tissue (WaT) by fucoxanthin in obese/diabetic kk-A y mice (4,5). expression of uncoupling protein 1 (ucP1), which plays an important role in energy expenditure, was induced by dietary fucoxanthin in WaT but not in brown adipose tissue; this ucP1 expression was responsible for the antiobesity effect of fucoxanthin. Furthermore, dietary fucoxanthin regulated adipocytokine secretion, thus preventing hyperglycemia in a type 2 diabetes kk-A y mouse model (5). The adipocyte as an endocrine cell has recently been recognized for its role in the secretion of biologically active mediators, termed adipokines/chemokines, including leptin, adiponectin, resistin, tumor necrosis factor-α (TnF-α) and monocyte chemoattractant protein-1 (McP-1) (6-8). Some adipokines are reported to alter insulin...

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

Anti-obesity and anti-diabetic effects of fucoxanthin on diet-induced obesity conditions in a murine model

Maeda$^{¹

2009

Mol Med Rep

241

176

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“…또한, punicic acid는 석류 씨에 풍부한 conjugated linolenic acid로, 암세포 증식 억제 효과 [6,7]와 항염증 [5] 효과가 있는 것으로 보고되어 있다. 최 근 여러 연구들에서 fucoxanthin과 punicic acid의 지방세포분 화 억제 작용과 고지방식이(high-fat diet)로 유도된 비만 마우 스에서의 항비만 효과가 밝혀졌다 [12,22,26]. Fucoxanthin은 3T3-L1전구지방세포에서 peroxisome proliferator-activated receptor (PPAR) gamma의 발현을 감소시킴으로써 지방세포 분화를 억제하였고, 고지방식이로 유도된 비만 마우스에서 uncoupling protein (UCP)-1의 발현을 증가시킴으로써 에너 지 소비를 촉진시켜 체중 및 식이효율, 복부부고환주위 백색 지방 등의 내장지방 무게를 유의적으로 감소시켰다 [12,20,21,22].…”

Section: 서 론unclassified

“…최 근 여러 연구들에서 fucoxanthin과 punicic acid의 지방세포분 화 억제 작용과 고지방식이(high-fat diet)로 유도된 비만 마우 스에서의 항비만 효과가 밝혀졌다 [12,22,26]. Fucoxanthin은 3T3-L1전구지방세포에서 peroxisome proliferator-activated receptor (PPAR) gamma의 발현을 감소시킴으로써 지방세포 분화를 억제하였고, 고지방식이로 유도된 비만 마우스에서 uncoupling protein (UCP)-1의 발현을 증가시킴으로써 에너 지 소비를 촉진시켜 체중 및 식이효율, 복부부고환주위 백색 지방 등의 내장지방 무게를 유의적으로 감소시켰다 [12,20,21,22]. Punicic acid는 3T3-L1전구지방세포에서 PPAR alpha와 gamma 수용체 활성을 증가시켜 공복시 혈당을 낮추 고, 당대사 능력을 개선시켰다 [10].…”

Section: 서 론unclassified

Improvement of High-fat Diet-induced Obesity by Xanthigen in C57BL/6N Mice

최경미¹,

이윤선

김원균³

et al. 2012

Journal of Life Science

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Obesity is a risk factor for numerous metabolic diseases. Recently, naturally occurring compounds that may improve obesity have received increasing attention. Xanthigen is a mixture of fucoxanthin and punicic acid derived from brown seaweed and pomegranate seed, respectively, which have been traditionally used for lipid-lowering effects in humans. In this study, we investigated whether Xanthigen attenuates high-fat diet-induced obesity in C57BL/6N mice. The mice were fed on a normal diet (ND), high-fat diet (HFD), HFD plus 1% Xanthigen or HFD plus 1% green tea extract (GTE) for 11 weeks. Food efficiency ratio (FER) and body weight were significantly reduced in mice fed HFD plus Xanthigen compared to HFD-fed mice. Consistent with the results in body weight change, Xanthigen also significantly decreased the weights of epididymal adipose tissue, retroperitoneal adipose tissue, and liver in HFD plus 1% Xanthigen-fed mice. The serum level of low-density lipoprotein (LDL)-cholesterol was significantly decreased in HFD plus Xanthigen-fed mice compared to HFD-fed mice. These results suggest that Xanthigen may be useful in the development of a functional health food for anti-obesity.

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“…Phosphorylation of AKT protein, which is related to insulin signaling, was induced in the fucoxanthin-fed group. Further treatment with fucoxanthinol 3T3-L1 adipocyte cells suppress adipocyte differentiation more strongly than those treated with fucoxanthin 25 . Moreover, amarouciaxanthin A suppressed preadipocyte cell differentiation accompanied by peroxisome proliferator-activated receptor γ PPARγ and CCAAT enhancer binding protein α C/EBP α protein expression.…”

Section: Anti-diabetic Effects Of Fucoxanthinmentioning

confidence: 99%