Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1

Das, Swadesh K.; Hashimoto, Takashi; Shimizu, Kazuo; Yoshida, Tatsushi; Sakai, Toshiyuki; Komoto, Akitoshi; Kanazawa, Kazuki

doi:10.1016/j.bbagen.2005.09.007

Cited by 152 publications

(110 citation statements)

References 43 publications

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“…Fucoxanthin had been reported to arrest the cell cycle [32] and induce apoptosis [10,32] in colon carcinoma cells. Regarding the induction of the phase II enzymes, however, little information is available for fucoxanthin.…”

Section: Discussionmentioning

confidence: 99%

Japanese Kelp (Kombu) Extract Suppressed the Formation of Aberrant Crypt Foci in Azoxymethane Challenged Mouse Colon

Das

Hashimoto

Baba

et al. 2006

J. Clin. Biochem. Nutr.

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Summary Japanese kelp (kombu) includes a xanthophy, fucoxanthin. In the present study, the chemopreventive activity against the formation of aberrant crypt foci (ACF, a preneoplastic marker for colon cancer) was examined. Four groups of mice were housed with drinking water containing 5 mg/ml of a kombu ethanol extract, and 0.05 mg/ml and 0.1 mg/ml of purified fucoxanthin, and with water alone as the positive control. They were subcutaneously injected with 10 mg/kg b.w. of azoxymethane (AOM) on the 1 st and 8 th days. Another group served as a negative control without kombu and AOM. The positive control produced a substantial number of ACF by the 28 th day. Significant reductions were found in the frequency of ACF: 36% for the kombu extract, 30% for 0.05 mg/ml fucoxanthin and 35% for 0.1 mg/ml fucoxanthin. In the liver of these mice, the kombu extract raised the level of activity of glutathione S-transferase (GST) and quinone reductase, and stimulated the antioxidant responsive element (ARE). Fucoxanthin enhanced the GST activity but did not affect the ARE. Thus, one of the kombu ingredients, fucoxanthin, can suppress the ACF formation induced by the colon carcinogen AOM, and other unknown ingredients can induce the ARE activation.

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Section: Discussionmentioning

confidence: 99%

Japanese Kelp (Kombu) Extract Suppressed the Formation of Aberrant Crypt Foci in Azoxymethane Challenged Mouse Colon

Das

Hashimoto

Baba

et al. 2006

J. Clin. Biochem. Nutr.

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“…6 In addition to studying CCND1 and c-Myc, 6 we further selected CHEK2, and Rb1, which are involved in negative cell cycle regulation, for this research. The Rb1 protein, a G 1 /S gate keeper, can prevent G 1 entry into S phase in order to avoid the duplication of damaged DNA, 7,8 which ensures high fidelity of genetic material. CHEK2 Breast cancer is a disease of cell cycle, and the dysfunction of cell cycle checkpoints plays a vital role in the occurrence and development of breast cancer.…”

Section: Introductionmentioning

confidence: 99%

Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients

Bai

Xia

et al. 2014

Cell Cycle

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“…Structure and biological activity of fucoxanthin and carotenoids in cancer cells [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] Biological functions of carotenoids in cell membranes [19][20][21][22] Interaction of carotenoids with lipid rafts [23] Cell model to study the integration of xenobiotics into lipid rafts [24] Antioxidant and pro-oxidant activity of fucoxanthin in animal cells and tissues [25][26][27] Structure and function of lipid rafts in cell membranes [28,29] Targeting lipid rafts in cancer cells [30][31][32][33][34][35][36] Ion channels, lipid rafts and cancer cells [37,38] Lipid rafts, cytoskeleton, cancer cells invasivity and tumor angiogenesis [30,40] …”

Section: Reference Numbersmentioning

confidence: 99%

“…Its antitumoral activity was validated in animal models, in which it limits tumor growth, angiogenesis and invasivity, suggesting a possible use for clinical oncology [1,15]. Studies focused on the pharmacology of fucoxanthin in cancer cells and tumors have revealed that it induces cell cycle arrest in G0/G1 phases [5], cyclins and CDK downregulation, CDK inhibitors up-regulation [16], as well as the common hallmarks of apoptosis (disturbance of the mitochondrial transmembrane potential, modulation of the expression of the Bcl-2 family proteins, activation of caspases/PARP/CAD, DNA fragmentation and phosphatidylserine exposure) (for review see [3]). …”

Section: Introductionmentioning

confidence: 99%

“…Particularly, fucoxanthin ( Figure 1), a marine carotenoid purified from brown micro-and macroalgae, attracts extensive interest owing to its antiproliferative, pro-apoptotic and pro-autophagic activities, demonstrated in a large panel of cancer cells [3][4][5][6][7][8][9][10][11][12][13][14]. Its antitumoral activity was validated in animal models, in which it limits tumor growth, angiogenesis and invasivity, suggesting a possible use for clinical oncology [1,15].…”

Section: Introductionmentioning

confidence: 99%

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Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

RG¹,

Thiery²,

Sergent³

et al. 2017

J Oceanogr Mar Res

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Fucoxanthin is a carotenoid present in brown micro-and macro algae, that induces apoptosis or autophagy in cancer cells grown in vitro. In vivo studies confirmed its interest as a natural anticancer compound, as it exerts antitumoral, antimetastatic and antiangiogenic activities in animal models. Studies focused on the pharmacology of fucoxanthin in cancer cells and tumors have revealed that it affects a wide panel of cellular, molecular and tissular processes, suggesting that its biological activity may be related in part to a nonspecific integration in cell membranes, and possible interaction with lipid rafts. Thus, preliminary data confirming this interaction of fucoxanthin with lipid rafts were obtained in mast cells and hepatoma WIF-B9 cells. We here discuss this hypothesis, in view of the critical function of lipid rafts in cancer cell survival, invasivity and communication with the tumoral microenvironment.

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Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1

Cited by 152 publications

References 43 publications

Japanese Kelp (Kombu) Extract Suppressed the Formation of Aberrant Crypt Foci in Azoxymethane Challenged Mouse Colon

Japanese Kelp (Kombu) Extract Suppressed the Formation of Aberrant Crypt Foci in Azoxymethane Challenged Mouse Colon

Multi-gene fluorescence in situ hybridization to detect cell cycle gene copy number aberrations in young breast cancer patients

Could Fucoxanthin Interaction with Lipid Rafts Mediate its Cytotoxicity in Cancer Cells?

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