Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice

Woo, Myoung-Nam; Jeon, Seon-Min; Kim, Hye-Jin; Lee, Mi-Kyung; Shin, Su‐Kyung; Shin, Young Chul; Park, Yong-Bok; Choi, Myung‐Sook

doi:10.1016/j.cbi.2010.05.006

Cited by 160 publications

(158 citation statements)

References 33 publications

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“…Woo et al [31] has reported the improvement effect of fucoxanthin on hepatic lipid profiles of C57BL/6N mice fed a high-fat diet containing 39% of calories as fat. Both 0.05% and 0.2% fucoxanthin supplementation signifycantly lowered triacylglycerol (TG) levels by 38% and 24%, respectively, and cholesterol levels by 26% and 24%, respectively, compared to the control group.…”

Section: Fnsmentioning

confidence: 99%

In Vivo Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-Ay Mice

Iwasaki¹,

Widjaja‐Adhi²,

Koide³

et al. 2012

FNS

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Dietary intake of 0.1% fucoxanthin significantly reduced lipid hydroperoxide levels of liver and abdominal white adipose tissue (WAT) of obese/diabetes KK-A y mice. The fucoxanthin supplementation also significantly reduced blood glucose level and hepatic lipid contents of the mice. Oxidative stress is known to be induced in hyperglycemia and high fat conditions. Therefore, in vivo antioxidant activity of fucoxanthin found in the present study could be attributed to its anti-diabetic effect and its decreasing effect on hepatic lipids. On the other hand, little effect of fucoxanthin on lipid hydroperoxide levels was found in normal ICR mice. Although the content of fucoxanthin metabolites in the abdominal WAT of KK-A y mice was about 50 times higher that in the liver, there was little difference in its in vivo antioxidant activity between in the liver and in the abdominal WAT. These results suggest that well-known ability of fucoxanthin to scavenge active oxygen species and/or free radicals would not be a main reason to explain its in vivo antioxidant activity.

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Section: Fnsmentioning

confidence: 99%

In Vivo Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-Ay Mice

Iwasaki¹,

Widjaja‐Adhi²,

Koide³

et al. 2012

FNS

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“…4,5 Most of all, resveratrol is a naturally occurring phytochemical in grapes, peanuts, and other plants, and it has been demonstrated to improve CVD, 6 obesity, 7 diabetes, 8 cancer, 9 and to regulate angiogenesis 10 as well as to ameliorate the aging process 11 since its bioactivity was first elucidated in the 1990's. Lovastatin, a 3-hydroxyl-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitor, is a member of the statin drug class used for lowering cholesterol in hypercholesterolemic patients.…”

Section: Introductionmentioning

confidence: 99%

Antiobesity and Vasoprotective Effects of Resveratrol in ApoE-Deficient Mice

Jeon

Lee

Choi

2014

Journal of Medicinal Food

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This study was performed to investigate the hypolipidemic, antiobese, and antiatherogenic effects of resveratrol in apoE-deficient mice fed an atherogenic diet (20% fat and 1% cholesterol). These animals were fed an atherogenic diet containing 0.02% lovastatin (w/w) or 0.02% resveratrol (w/w) for 12 weeks. Resveratrol and lovastatin supplementation significantly reduced either the body weight or epididymal fat weight without altering the food intake and food efficiency ratio. Resveratrol significantly decreased the plasma total cholesterol (total-C), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C) concentrations, apoB/apoA-I ratio, hepatic cholesterol, and triglyceride (TG) contents, whereas significantly it increased the plasma HDL-C concentration compared with the control and lovastatin groups. Plasma and hepatic TG and plasma apoB levels were significantly lower in both the lovastatin and resveratrol groups than in the control group without altering the plasma apoA-I concentration. Both resveratrol and lovastatin significantly decreased hepatic fatty acid and TG synthesis, whereas they increased fatty acid oxidation (b-oxidation) except for the carnitine palmitoyltransferase activity compared with the control group. However, there was no difference in hepatic 3-hydroxyl-3-methylglutaryl-CoA reductase activity among the groups, although hepatic acyl-CoA: cholesterol acyltransferase activity was significantly lower in the lovastatin groups than in the control group. In epididymal adipose tissue, resveratrol supplementation led to an increase in b-oxidation and decrease in TG synthesis, compared with the control group. Tissue morphology revealed that there were dramatic decreases in hepatic lipid droplets and aortic fatty streaks by resveratrol and lovastatin supplementation. This study demonstrates that resveratrol exerts not only antiobesity and hypolipidemic effects, but also protective effects for the liver and aorta through the modulation of lipid metabolism in both the liver and white adipose tissues.

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“…Inhibition of α-amylase has been noted for purified phlorotannins from another brown alga, Ecklonia cava (Lee et al 2009). Dietary fucoxanthin (a carotenoid), which also is found in edible brown seaweeds, reportedly reduced blood glucose and plasma insulin levels in diabetic/obese KK-A y mice (Maeda et al 2007) and lowered blood glucose and HbA1C in nondiabetic, high-fat diet mice (Woo et al 2010). However, this species was not selected for further study due to its cytotoxic effect on the cell line related to this study (Data not shown).…”

Section: Discussionmentioning

confidence: 97%

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

et al. 2015

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Eucheuma denticulatum is a red edible seaweed that grows in the East Malaysia coastal region. The objective of this study was to investigate the α-amylase, antioxidant and anti-inflammatory activities of E. denticulatum ethanol extract and its three fractions (n-hexane, ethyl acetate and acetone). α-Amylase activity was assessed by dinitrosalicylic acid (DNS) assay, while the antioxidant property was determined by oxygen radical absorbance capacity (ORAC) analysis. The anti-inflammatory effects of the seaweed samples were evaluated by nitric oxide (NO), interleukin-6 (IL-6), interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) activities on the interferon-gamma/lipopolysaccharide (IFN-γ/LPS)-stimulated murine macrophage cell line (RAW 264.7) using Griess reaction and immunoassays, respectively. At 10 mg mL −1 , E. denticulatum ethanol extract and three fractions inhibited α-amylase activities at variable levels. The highest (67 %) inhibition of α-amylase enzyme was by the ethanol crude extract. The three fractions showed inhibition with a mean of 42 %. Crude ethanol extracts also exhibited higher antioxidant capacity (36,400 ±23.5 mol Trolox equivalent (TE) (100 g) −1 ) when compared to the fractions. Crude extract and fractions (1-100 μg mL −1 ), also exhibited anti-inflammatory activity without showing any cytotoxic effect to RAW 264.7 cells. The present study suggests that E. denticulatum has the potential to be a promising source of effective functional metabolite. An extensive research on the edible varieties would contribute to a better understanding of their importance as functional food.

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Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice

Cited by 160 publications

References 33 publications

<i>In Vivo</i> Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-<i>A<sup>y</sup></i> Mice

<i>In Vivo</i> Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-<i>A<sup>y</sup></i> Mice

Antiobesity and Vasoprotective Effects of Resveratrol in ApoE-Deficient Mice

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

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Fucoxanthin supplementation improves plasma and hepatic lipid metabolism and blood glucose concentration in high-fat fed C57BL/6N mice

Cited by 160 publications

References 33 publications

&lt;i&gt;In Vivo&lt;/i&gt; Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-&lt;i&gt;A&lt;sup&gt;y&lt;/sup&gt;&lt;/i&gt; Mice

&lt;i&gt;In Vivo&lt;/i&gt; Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-&lt;i&gt;A&lt;sup&gt;y&lt;/sup&gt;&lt;/i&gt; Mice

Antiobesity and Vasoprotective Effects of Resveratrol in ApoE-Deficient Mice

Alpha-amylase, antioxidant, and anti-inflammatory activities of Eucheuma denticulatum (N.L. Burman) F.S. Collins and Hervey

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<i>In Vivo</i> Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-<i>A<sup>y</sup></i> Mice

<i>In Vivo</i> Antioxidant Activity of Fucoxanthin on Obese/Diabetes KK-<i>A<sup>y</sup></i> Mice