Full-field ERG and visual fields in patients 5 years after discontinuing vigabatrin therapy

Kjellström, Ulrika; Lövestam-Adrian, Monica; Andréasson, Sten; Ponjavic, Vesna

doi:10.1007/s10633-007-9108-3

Cited by 15 publications

(10 citation statements)

References 39 publications

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“…In the present study, OPs were decreased in both high-dose and low-dose rabbits, reflecting disturbances in inner retinal function, in accordance with several clinical studies revealing OP alterations [11,13,18,19,23,[25][26][27][28]. b-wave amplitudes derived from the isolated cone responses both in rabbits [37,38] and humans [16,49], a well-known phenomenon in VGB treatment [11, 13, 16, 18-20, 22-25, 49],which also has been described in rats [39]. One drawback of the present study is that these results were not repeated.…”

Section: Discussionsupporting

confidence: 91%

Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medication

Kjellström

Bruun

Ghosh

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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In this study, VGB medication was associated, in a dose-related manner, with a decrease of ff-ERG amplitudes as well as with altered protein expression in rod bipolar cells and Müller cells, suggesting alterations of inner retinal function. The dose-related morphological and electrophysiological changes indicate a retinal pathology that may explain the constricted visual fields seen in some patients treated with VGB.

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Section: Discussionsupporting

confidence: 91%

Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medication

Kjellström

Bruun

Ghosh

et al. 2009

Graefes Arch Clin Exp Ophthalmol

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“…The visual field defects persist after withdrawal of the drug (Nousiainen et al. 2001; Kjellstrom et al. 2008).…”

Section: Introductionmentioning

confidence: 99%

Retinal nerve fibre layer attenuation: clinical indicator for vigabatrin toxicity

Moseng¹,

Sæter²,

Mørch-Johnsen³

et al. 2011

Acta Ophthalmologica

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. Purpose: To investigate whether persistent visual field defects among patients exposed once to the antiepileptic drug vigabatrin (VGB) were associated with peripapillary retinal nerve fibre layer thickness (RNFLT) attenuation. Methods: Nine individuals with partial epilepsy and VGB‐attributed visual field loss (group 1; 18 eyes) and seven age‐ and gender‐matched individuals with epilepsy and no previous VGB exposure (group 2; 14 eyes) were included in the study. Full‐field 120 point screening perimetry out to 60 degrees from central fixation using the Humphrey Field Analyzer was performed. RNFLT was quantified by optical coherence tomography (OCT) using Fast RNFLT protocol, Stratus OCT (3.0) after pupillary dilation. The results from the right eye are presented in this article. Results: Among the patients with VGB‐attributed visual field loss, five patients had only peripheral field defect (group 1a) and the remaining four had advanced field defects both in the periphery and within 30° from central fixation (group 1b). None of the patients in the control group had manifest visual field loss. The mean RNFLT among the patients with VGB‐attributed visual field loss was significantly attenuated compared to the controls [mean total RNFLT: group 1: 75.6 ± 12.7 μm, group 2: 103.5 ± 9.7 μm, mean difference 27.9 μm, (CI 15.9–39.9; p < 0.001)]. RNFLT values classified as borderline according to normative database (Stratus OCT) occurred more frequently among individuals with VGB‐attributed visual field loss than in controls (frequency in group 1: 6/9; group 2: 0/7, p = 0.011). The nasal, superior and inferior quadrants of RNFLT in individuals with VGB‐attributed visual field loss were significantly attenuated, while no difference was detected in temporal quadrants compared to controls. Both individuals with peripheral and those with advanced visual field losses in the VGB group had attenuated mean total RNFLT compared to controls (p = 0.006, p = 0.002, respectively). Occurrence of borderline classification of total RNFLT ≤5th percentile was more frequent among individuals with advanced visual field loss than among controls (p = 0.048). Conclusion: Persistent visual field loss attributed to VGB is associated with reduced peripapillary RNFLT and was detected both among patients with advanced and among patients with only peripheral visual field defects. Measurements of RNFLT with OCT might be considered as a diagnostic supplement in the follow‐up of patients exposed to vigabatrin.

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“…Le rétrécissement du champ visuel et la diminution des réponses de l'ERG flash persistent plusieurs années après la cessation du vigabatrin [Kjellstrom et al, 2008]. L'examen clinique trouve des plis choroïdiens à gauche, bien mis en évidence par l'angiographie ; ils ne sont pas en rapport avec un processus intra-orbitaire, la tomodensitométrie et l'IRM étant normales.…”

Section: éVolution Fonctionnelle Selon La Littératureunclassified

Vi-2 : Apport De l'ÉLECTROPHYSIOLOGIE Chez l'ADULTE : Exemples

Rigaudière¹,

Gargasson²

2012

Oeil Et Physiologie De La Vision

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Full-field ERG and visual fields in patients 5 years after discontinuing vigabatrin therapy

Abstract: Vigabatrin attributed visual field constriction and reduced ff-ERG responses remain several years after discontinuing vigabatrin therapy, indicating drug-induced permanent retinal damage.

Cited by 15 publications

References 39 publications

Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medication

Dose-related changes in retinal function and PKC-alpha expression in rabbits on vigabatrin medication

Retinal nerve fibre layer attenuation: clinical indicator for vigabatrin toxicity

Vi-2 : Apport De l'ÉLECTROPHYSIOLOGIE Chez l'ADULTE : Exemples

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