Full-mouth treatment modalities (within 24 hours) for periodontitis in adults

Jervøe‐Storm, Pia‐Merete; Eberhard, Jörg; Needleman, Ian; Worthington, Helen V; Jepsen, Søren

doi:10.1002/14651858.cd004622.pub4

Cited by 13 publications

(16 citation statements)

References 78 publications

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“…‡ Furthermore, tooth mobility and sensitivity to thermal testing were assessed. Immediately afterward, patients received a full-mouth subgingival treatment 32 using sonic and air-polishing devices. § If necessary, special hand instruments, that is, area specific curettes ** were used.…”

Section: Study Design Participants and Periodontal Treatment Protocolmentioning

confidence: 99%

Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

Laky,

Bruckmann,

Blumenschein

et al. 2023

Journal of Periodontology

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BackgroundThe aim of this double‐blind randomized placebo‐controlled clinical trial was to evaluate the efficacy of a multinutrient supplement as an add‐on therapy to scaling and root planing for patients with periodontitis.MethodsForty‐two patients with stage III or IV periodontitis were randomly allocated to a 2‐month treatment of either a multinutrient supplement containing vitamin C, vitamin E, zinc, selenium, alpha‐lipoic‐acid, cranberry extract, grapeseed extract, and coenzyme Q10 or placebo capsules as an adjunct to conservative periodontal therapy. Periodontal parameters, including probing pocket depth, gingival recession, bleeding on probing, approximal plaque index, and papillary bleeding index, were assessed. Clinical attachment loss, periodontal inflamed surface area, periodontal epithelial surface area, and percentages of pocket sites with ≤3, ≤4, ≥5, ≥6, ≥7, and ≥4 mm with bleeding on probing were calculated.ResultsAll clinical parameters significantly improved from baseline to reevaluation within each group (p < 0.05). Multinutrient intake resulted in a significantly higher reduction of probing‐pocket‐depth (−0.75 ± 0.42 mm) and bleeding‐on‐probing (−21.9 ± 16.1%) from baseline to reevaluation compared with placebo (−0.51 ± 0.30 mm, p = 0.040 and −12.5 ± 9.8%, p = 0.046, respectively). All periodontal parameters showed insignificantly higher improvements in patients receiving the supplement compared with those receiving the placebo (p > 0.05).ConclusionsMultinutrient supplementation as an adjunct to nonsurgical treatment of periodontitis showed some additional benefit regarding probing‐pocket‐depth and bleeding‐on‐probing. However, the clinical relevance needs to be further explored.

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Section: Study Design Participants and Periodontal Treatment Protocolmentioning

confidence: 99%

Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

Laky,

Bruckmann,

Blumenschein

et al. 2023

Journal of Periodontology

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show abstract

“…This roughly 8% increased percentage of pocket closure does not approach the 14.4% pocket closure that may be attained with greater antibiotic administration 28 . In this regard, some recent studies and meta‐analyses, 21,30 which evaluated the different non‐surgical approaches, confirmed the previous findings 31 that periodontal treatment positively affects clinical parameters and that there is no great clinical difference between different SRP protocols. Our study may have produced statistically significant results that were more favorable than those of the trials included in these meta‐analyses due, in part, to the inclusion of a different number of patients if compared with each other 21 .…”

Section: Discussionmentioning

confidence: 76%

Impact of N‐terminal pro‐B‐type natriuretic peptide and related inflammatory biomarkers on periodontal treatment outcomes in patients with periodontitis: An explorative human randomized‐controlled clinical trial

Isola

Tartaglia

Santonocito

et al. 2023

Journal of Periodontology

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BackgroundN‐terminal portion of the B‐type natriuretic propeptide (NT‐proBNP) has potentially been shown to play an important role in the development of periodontitis and cardiovascular disease (CVD). This study evaluated the efficacy of periodontal treatment on NT‐proBNP and related CVD biomarkers and explored whether subjects harboring high NT‐proBNP at baseline showed increased clinical benefits with the non‐surgical periodontal treatment performed with full‐mouth scaling and root planing (FM‐SRP) at 6‐month follow‐up.MethodsForty‐eight patients with stage III periodontitis were randomized to receive minimal standard oral care (SOC) (n = 24) or FM‐SRP (n = 24) protocol. Clinical periodontal parameters (probing depth, clinical attachment loss, bleeding on probing), serum NT‐proBNP, α1‐antitrypsin, C‐reactive protein (hs‐CRP), endothelial cell‐specific molecule‐1 (ECM‐1), and neutrophil gelatinase‐associated lipocalin (NGAL) concentrations were assessed at baseline and at 1‐, 3‐, and 6‐ month follow‐up.ResultsAt 6 months, FM‐SRP was more effective than SOC in reducing periodontal parameters and mean proportions of NT‐proBNP (p = 0.004), hs‐CRP (p = 0.003), α1‐antitrypsin (p = 0.012), ECM‐1 (p = 0.014), and NGAL (p = 0.045). At 6‐month follow‐up, the reduced NT‐proBNP, α1‐antitrypsin, hs‐CRP, ECM‐1, and NGAL levels were significantly correlated with the extent of periodontitis (p < 0.05). Furthermore, the analysis of variance analysis evidenced that, at 6‐month follow‐up, FM‐SRP significantly impacted the reduction of NT‐proBNP, hs‐CRP, ECM‐1, and NGAL. Moreover, high levels of NT‐proBNP, hs‐CRP, ECM‐1, and NGAL at baseline significantly influenced the efficacy of periodontal treatment positively.ConclusionIn this study, FM‐SRP was more effective than SOC in reducing clinical variables and NT‐proBNP levels, although subjects who harbored high NT‐proBNP concentrations at baseline showed greater clinical benefits of periodontal treatment at 6‐month follow‐up.

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“…In particular, the improvement in PD pocket closure does not be approached with higher antibiotic consumption [28]. In this regard, some recent studies and meta-analyses [30,21] con rmed the previous ndings [31] that periodontal therapy in uences clinical parameters and that there is no clinical variation across SRP methods. In this regard, the present study may have achieved statistically signi cant results that were more favorable results due to the differing number of patients included in the present study compared to other similar ones [21].…”

Section: Discussionmentioning

confidence: 96%

Growth differentiation factor-15 as predictor of periodontal treatment effects in patients with periodontitis: a randomized-controlled clinical trial

Isola

Tartaglia

Santonocito

et al. 2023

Preprint

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Background: It has been shown that periodontal treatment could potentially decrease the risk of developing cardiovascular disease (CVD) and that growth differentiation factor 15 (GDF-15) is a valuable biomarker of early CVD risk. This study evaluated the efficacy of periodontal treatment on growth differentiation factor 15 (GDF-15) and related circulating systemic risk biomarkers such as glutathione peroxidase 1 (GPx-1), c-reactive protein (hs-CRP), and surfactant protein D (SP-D) and explored whether patients with high GDF-15 at baseline showed increased clinical benefits with two non-surgical treatments protocols at 6-months follow-up. Methods: Patients with periodontitis were randomized to receive quadrant (Q-SRP, n=23) or full-mouth disinfection (FMD, n=23) protocols. Clinical and periodontal parameters were recorded in all enrolled patients. Serum concentrations of GDF-15, GPx-1, hs-CRP, and SP-D concentrations were assessed at baseline and 30, 90, and 180-days follow-up through enzyme-linked immunosorbent assay (ELISA) and nephelometric assay techniques. Results: Q-SRP was more effective than FMD in lowering periodontal parameters, and the mean proportions of GDF-15 (p=0.005), GPx-1 (p=0.025), hs-CRP (p<0.001), and SP-D (p=0.042) after 6 months of treatment. Periodontal parameters were significantly associated with concentrations of GDF-15, GPx-1, hs-CRP, and SP-D at 6-months follow-up. Furthermore, the ANOVA analysis revealed that Q-SRP significantly influenced the upregulation of GPx-1 and on downregulation of GDF-15, and SP-D and substantially impacted the effectiveness of periodontal therapy at 6 months follow-up. Conclusion: The results evidenced that, in comparison with FMD, Q-SRP was more effective at reducing periodontal variables and positively impacting GDF-15, GPx-1, hs-CRP, and SP-D concentrations, although patients who exhibited higher GDF-15 and SP-D and lowered GPx-1 at baseline, more benefited the effects of periodontal treatment at 6-month follow-up.

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Full-mouth treatment modalities (within 24 hours) for periodontitis in adults

Abstract: Analysis 2.2. Comparison 2: Full-mouth disinfection (FMD) versus control, Outcome 2: Change in clinical attachment level: whole mouth, single-and multi-rooted teeth.

Cited by 13 publications

References 78 publications

Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

Effect of a multinutrient supplement as an adjunct to nonsurgical treatment of periodontitis: A randomized placebo‐controlled clinical trial

Impact of N‐terminal pro‐B‐type natriuretic peptide and related inflammatory biomarkers on periodontal treatment outcomes in patients with periodontitis: An explorative human randomized‐controlled clinical trial

Growth differentiation factor-15 as predictor of periodontal treatment effects in patients with periodontitis: a randomized-controlled clinical trial

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