Full-spectrum responsive ZrO₂-based phototheranostic agent for NIR-II photoacoustic imaging-guided cancer phototherapy

Abstract

Second near-infrared (NIR-II) window responsive phototheranostic agents have a precise spatiotemporal potential for the diagnosis and treatment of cancer. In this study, a full-spectrum responsive ZrO2-based phototheranostic agent was found...

In situ assembled titanium carbide-based heterojunctions for the synergistic enhancement of NIR-II photothermal/photodynamic therapy against breast cancer

“…In this study, the HJs absorption edge was tuned from ultraviolet for TiO 2 to the entire visible-NIR-II region, which should be contributed by the reduced bandgap of HJs. The fluorescence spectra of the HJs was used to reveal the electron recombination processes of the photogenerated hole pairs; 46,47 the results are shown in Fig. S5 (ESI†).…”

“…In this study, the HJs absorption edge was tuned from ultraviolet for TiO 2 to the entire visible-NIR-II region, which should be contributed by the reduced bandgap of HJs. The fluorescence spectra of the HJs was used to reveal the electron recombination processes of the photogenerated hole pairs; 46,47 mixed with different Ti 3 C 2 /TiO 2 -PVP HJs solutions and irradiated with a 660 nm laser for 10 min, the characteristic peak (428 nm) of the 1 O 2 probe gradually decreased as the laser irradiation time increased, suggesting the continuous production of 1 O 2 (Fig. 2G).…”

Mechanisms of Reactive Oxygen Species Generated by Inorganic Nanomaterials for Cancer Therapeutics

“…This full-spectrum responsive B@ZrO 2 −OV was modified with HA to obtain ZrO 2−x −B@SiO 2 −HA, which exhibits improved water dispersibility and the ability to target tumor cells ( Figure 2B). The obtained ZrO 2−x −B@SiO 2 −HA also shows promise for high-resolution photoacoustic imaging along with remarkable synergistic PTT/PDT treatment effect upon 1064-nm laser irradiation (Zhu et al, 2020). Mou et al developed green titania (G−TiO 2−x ) with excellent NIR absorption by altering the lattice of black titania (B−TiO 2−x ) via strong ultrasonication, and further conjugated G−TiO 2−x with triphenylphosphonium (TPP) ligand to obtain G−TiO 2−x −TPP, which exhibits mitochondria-targeting ability for combined PTT/ PDT precise cancer therapy ( Figure 2C) (Mou et al, 2017).…”

Beyond traditional light: NIR-II light-activated photosensitizers for cancer therapy

“…6a). 86 The ZrO 2− x -B@SiO 2 -HA agent exhibited full spectral absorption properties due to the oxygen vacancies and boron doping (Fig. 6b), enabling high NIR-II photothermal conversion and significant ROS generation (Fig.…”