Fullerene mediates proliferation and cardiomyogenic differentiation of adipose-derived stem cells via modulation of MAPK pathway and cardiac protein expression

Hao, Tong; Zhou, Jin; Lu, Shuaiyao; Yang, Boguang; Wang, Yan; Fang, Wancai; Jiang, Xiaoxia; Lin, Qiuxia; Li, Junjie; Wang, Changyong

doi:10.2147/ijn.s95863

Cited by 13 publications

(4 citation statements)

References 45 publications

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“…177 Processability of highly aligned 1D fullerene whisker scaffolds by interfacial alignment enables concurrent control over cellular orientation and differentiation to skeletal muscle cells and cardiomyogenic differentiation. 178,179 Nevertheless, the electrical properties of fullerenes, fullerene 1D whiskers, and 2D fullerene mats, their tunability, their eventual impact on enhancing cellular responses in vitro with fullerenebased tissue engineering scaffolds, and finally, their impact under electrical stimulation still need to be investigated in detail.…”

Section: Current Challenges and Future Perspectivementioning

confidence: 99%

Carbon nanomaterials‐based electrically conductive scaffolds for tissue engineering applications

Abd,

Díaz,

Gupta

et al. 2024

MedComm – Biomaterials and Applications

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In tissue engineering, the pivotal role of scaffolds is underscored, serving as key elements to emulate the native extracellular matrix. These scaffolds must provide structural integrity and support and supply electrical, mechanical, and chemical cues for cell and tissue growth. Notably, electrical conductivity plays a crucial role when dealing with tissues like bone, spinal, neural, and cardiac tissues. However, the typical materials used as tissue engineering scaffolds are predominantly polymers, which generally characteristically feature poor electrical conductivity. Therefore, it is often necessary to incorporate conductive materials into the polymeric matrix to yield electrically conductive scaffolds and further enable electrical stimulation. Among different conductive materials, carbon nanomaterials have attracted significant attention in developing conductive tissue engineering scaffolds, demonstrating excellent biocompatibility and bioactivity in both in vitro and in vivo settings. This article aims to comprehensively review the current landscape of carbon‐based conductive scaffolds, with a specific focus on their role in advancing tissue engineering for the regeneration and maturation of functional tissues, emphasizing the application of electrical stimulation. This review highlights the versatility of carbon‐based conductive scaffolds and addresses existing challenges and prospects, shedding light on the trajectory of innovative conductive scaffold development in tissue engineering.

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Section: Current Challenges and Future Perspectivementioning

confidence: 99%

Carbon nanomaterials‐based electrically conductive scaffolds for tissue engineering applications

Abd,

Díaz,

Gupta

et al. 2024

MedComm – Biomaterials and Applications

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“…180,181 In addition to the materials mentioned above, carbon-based materials also have the magnificent potential to result in electroactivity. These include graphite, 182,183 graphene, [184][185][186] graphene oxide, 187,188 reduced graphene oxide, [189][190][191] carbon nanofibers, 60,[192][193][194] carbon nanotubes, 156,195,196 fullerene, 197,198 carbon quantum dots, [199][200][201] and nanodiamonds. [202][203][204] Particular mechanical, electrical, thermal, and optical properties bring about the opportunity for carbon-based nanomaterials to be involved in the field of tissue repair.…”

Section: Electrical Conductivitymentioning

confidence: 99%

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Jalilinejad

Rabiee

Baheiraei

et al. 2022

Bioengineering & Transla Med

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A proper self‐regenerating capability is lacking in human cardiac tissue which along with the alarming rate of deaths associated with cardiovascular disorders makes tissue engineering critical. Novel approaches are now being investigated in order to speedily overcome the challenges in this path. Tissue engineering has been revolutionized by the advent of nanomaterials, and later by the application of carbon‐based nanomaterials because of their exceptional variable functionality, conductivity, and mechanical properties. Electrically conductive biomaterials used as cell bearers provide the tissue with an appropriate microenvironment for the specific seeded cells as substrates for the sake of protecting cells in biological media against attacking mechanisms. Nevertheless, their advantages and shortcoming in view of cellular behavior, toxicity, and targeted delivery depend on the tissue in which they are implanted or being used as a scaffold. This review seeks to address, summarize, classify, conceptualize, and discuss the use of carbon‐based nanoparticles in cardiac tissue engineering emphasizing their conductivity. We considered electrical conductivity as a key affecting the regeneration of cells. Correspondingly, we reviewed conductive polymers used in tissue engineering and specifically in cardiac repair as key biomaterials with high efficiency. We comprehensively classified and discussed the advantages of using conductive biomaterials in cardiac tissue engineering. An overall review of the open literature on electroactive substrates including carbon‐based biomaterials over the last decade was provided, tabulated, and thoroughly discussed. The most commonly used conductive substrates comprising graphene, graphene oxide, carbon nanotubes, and carbon nanofibers in cardiac repair were studied.

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“…C60(OH)24 may attenuate oxidative stress-induced apoptosis via augmentation of Nrf2-regulated cellular antioxidant capacity, thus providing insights into the mechanisms of antioxidant properties of C60(OH)24 [25]. Fullerenes mediate proliferation and cardiomyogenic differentiation of adipose-derived stem cells via the modulation of MAPK pathway and cardiac protein expression [26]. Fullerenols (hydroxylated fullerenes) inhibit the crosstalk between bone marrow-derived mesenchymal stem cells and tumor cells by regulating MAPK signaling [27].…”

Section: Introductionmentioning

confidence: 99%

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-inflammatory Pathways

Проскурнина¹,

Mikheev²,

Savinova³

et al. 2021

Preprint

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Background: Fullerenes and metallofullerenes can be considered promising nanopharmaceuticals themselves and as a basis for chemical modification. As reactive oxygen species homeostasis plays a vital role in cells, the study of their effect on genes involved in oxidative stress and anti-inflammatory response is of particular importance. Methods: Human fetal lung fibroblasts were incubated with aqueous dispersions of C60, C70, and Gd@C82 in concentrations of 5 nM and 1.5 µM for 1, 3, 24, and 72 hours. Cell viability, intracellular ROS, NOX4, NFκB, PRAR-γ, NRF2, heme oxygenase 1, and NAD(P)H quinone dehydrogenase 1 expression have been studied. Results &amp; conclusion: The aqueous dispersions of C60, C70, and Gd@C82 fullerenes are active participants in ROS homeostasis. Low and high concentrations of AFDs have similar effects. C70 was the most inert substance, C60 was the most active substance. All AFDs have both a “prooxidant” and “antioxidant” effect, but with a different balance. Gd@C82 was a substance with more pronounced antioxidant and anti-inflammatory properties, while C70 had more pronounced “prooxidant” properties.

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Fullerene mediates proliferation and cardiomyogenic differentiation of adipose-derived stem cells via modulation of MAPK pathway and cardiac protein expression

Cited by 13 publications

References 45 publications

Carbon nanomaterials‐based electrically conductive scaffolds for tissue engineering applications

Carbon nanomaterials‐based electrically conductive scaffolds for tissue engineering applications

Electrically conductive carbon‐based (bio)‐nanomaterials for cardiac tissue engineering

Effects of Aqueous Dispersions of C60, C70 and Gd@C82 Fullerenes on Genes Involved in Oxidative Stress and Anti-inflammatory Pathways

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