Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera

Faizi, Shaheen; Siddiqui, Bina Shaheen; Saleem, Rubeena; Siddiqui, Salimuzzaman; Aftab, Khalid; Gilani, Anwarul Hassan

doi:10.1016/0031-9422(94)00729-d

Cited by 171 publications

(108 citation statements)

References 17 publications

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“…coat, pulp and seed revealed that the blood pressure lowering effect of seed was more pronounced with comparable results in both ethanol and water extracts indicating that the activity is widely distributed (Faizi et al, 1998). Activity-directed fractionation of the ethanol extract of pods of M. oleifera has led to the isolation of thiocarbamate and isothiocyanate glycosides which are known to be the hypotensive principles (Faizi et al, 1995). Methyl phydroxybenzoate and β-sitosterol (14), investigated in the pods of M. oleifera have also shown promising hypotensive activity (Faizi et al, 1998).…”

Section: Antihypertensive Diuretic and Cholesterol Lowering Activitiesmentioning

confidence: 98%

“…Nitrile, mustard oil glycosides and thiocarbamate glycosides have been isolated from Moringa leaves, which were found to be responsible for the blood pressure lowering effect (Faizi et al, 1994a;. Most of these compounds, bearing thiocarbamate, carbamate or nitrile groups, are fully acetylated glycosides, which are very rare in nature (Faizi et al, 1995). Bioassay guided fractionation of the active ethanol extract of Moringa leaves led to the isolation of four pure compounds, niazinin A [1], niazinin [1] B, niazimicin [4] and niazinin A + B which showed a blood pressure lowering effect in rats mediated possibly through a calcium antagonist effect (Gilani et al, 1994a).…”

Section: Antihypertensive Diuretic and Cholesterol Lowering Activitiesmentioning

confidence: 99%

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Moringa oleifera: a food plant with multiple medicinal uses

Anwar

Latif

Ashraf

et al. 2006

Phytotherapy Research

1,528

1,048

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Section: Antihypertensive Diuretic and Cholesterol Lowering Activitiesmentioning

confidence: 98%

Section: Antihypertensive Diuretic and Cholesterol Lowering Activitiesmentioning

confidence: 99%

Moringa oleifera: a food plant with multiple medicinal uses

Anwar

Latif

Ashraf

et al. 2006

Phytotherapy Research

1,528

1,048

View full text Add to dashboard Cite

show abstract

“…Plant juice shows liver protective properties (Subramonium & Pushpangadan 1999). A leaf extract possesses hypotensive activity (Faizi et al 1995). Plant root wood extracts reduce the risk of stone formation (Karadi et al 2006).Ethanol root extract are hypocholesterolemic (Mehta et al 2003).…”

Section: Sahjwan (N) Shigru Shobhanjana (S) Raw Fruit Is Valued Fomentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

346

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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“…M. oleifera has been regarded as a 'miracle tree', as it is a significant source of fats, proteins, β-carotene, vitamin C, iron, potassium and other nutrients, and is also effective in the treatment of numerous diseases (4)(5)(6)(7)(8)(9)(10)(11)(12)(13). The flowers, roots, leaves and bark of M. oleifera have long been used by the public as nutritional supplements and foods, as well as in the manufacture of perfume, skin oil and other products (12,(14)(15)(16)(17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

2015

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Abstract. It has previously been reported that cold water-extracts of Moringa oleifera leaf have anticancer activity against various human cancer cell lines, including non-small cell lung cancer. In the present study, the anticancer activity of M. oleifera leaf extracts was investigated in human hepatocellular carcinoma HepG2 cells. By the analysis of apoptotic signals, including the induction of caspase or poly(ADP-ribose) polymerase cleavage, and the Annexin V and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assays, it was demonstrated that M. oleifera leaf extracts induce the apoptosis of HepG2 cells. In the hollow fiber assay, oral administration of the leaf extracts significantly reduced (44-52%) the proliferation of the HepG2 cells and A549 non-small cell lung cancer cells. These results support the potential of soluble extracts of M. oleifera leaf as orally administered therapeutics for the treatment of human liver and lung cancers.

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Fully acetylated carbamate and hypotensive thiocarbamate glycosides from Moringa oleifera

Cited by 171 publications

References 17 publications

Moringa oleifera: a food plant with multiple medicinal uses

Moringa oleifera: a food plant with multiple medicinal uses

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

A potential oral anticancer drug candidate, Moringa oleifera leaf extract, induces the apoptosis of human hepatocellular carcinoma cells

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