Fully automated drug liberation apparatus for semisolid preparations based on sequential injection analysis

Solich, Petr; Sklenářová, Hana; Huclová, Jitka; Šatı́nský, Dalibor; Schaefer, Ulrich F.

doi:10.1016/j.aca.2003.09.002

Cited by 22 publications

(10 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To test the extent of liberation of the active ingredients in semi-solid formulations, Klimundová et al coupled the SIA mountings to a liberation apparatus known as the Franz cell [150]. In this work, membranes from different materials (poly-carbonate, mixed esters of cellulose, teflon, silicon, poly-vinylidene fluoride) and different pore diameters were studied, to compare the dissolution profiles of indomethacin 1% gel.…”

Section: Automated Drug-dissolution and Drug-release Testingmentioning

confidence: 99%

Application of sequential injection analysis to pharmaceutical analysis

Pimenta

Montenegro

Araújo

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Section: Automated Drug-dissolution and Drug-release Testingmentioning

confidence: 99%

Application of sequential injection analysis to pharmaceutical analysis

Pimenta

Montenegro

Araújo

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

“…polysulphone, esters of cellulose, teflon, polycarbonate, polyvinylidene fluoride, silicone etc. [7,8].…”

Section: Introductionmentioning

confidence: 97%

“…ibuprofen [4], analgetic tablets with aspirin, phenacetin and caffeine [5], and tablets with ergotamine tartrate [6]. Firstly, the SIA system described for monitoring of release profile was suggested by our group for tests of indomethacin [7].…”

Section: Introductionmentioning

confidence: 99%

Automated system for release studies of salicylic acid based on a SIA method

Klimundová

Sklenářová

Schaefer

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

“…Several flow systems using several detection techniques have been developed for pharmaceutical analysis aiming at the continuous monitoring of dynamic processes [15][16][17][18][19]. An automated system based on the Sequential Injection Analysis (SIA) technique coupled with the Franz cell to study release rates of indomethacin from gels has been implemented [20]. A similar device has been applied to in vitro release studies of salicylic acid from semisolid dosage forms [21].…”

Section: Introductionmentioning

confidence: 99%

On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography

Alves

Ramos

Nunes

et al. 2016

Talanta

Self Cite

View full text Add to dashboard Cite

A low-pressure liquid chromatography system for the on-line quantification of caffeine loaded into lipid nanoparticles that permeates pig skin was developed. The apparatus includes a Franz diffusion cell with computer-controlled sampling that allows collection of acceptor solution with automatic compensation for sample withdrawing, and a C-18 reversed-phase monolithic column integrated in a typical Flow Injection Analysis (FIA) set-up where separation between caffeine and other matrix elements is performed before spectrophotometric quantification at 273 nm. Several parameters regarding chromatographic analysis (propulsion element, column length, mobile phase composition, and flow rate) were studied along with the establishment of the sampling procedure. Under the selected conditions (monolithic column Chromolith® RP-18 15 mm × 4.6 mm i.d., acetonitrile:water 10:90 (v/v), flow rate 0.45 mL min(-1)) a detection limit of 4 μM and RSD values for caffeine concentration <2% were achieved. High recovery values were obtained when Hepes buffer incubated as acceptor solution in presence of pig skin for 8 h was spiked with caffeine (103±5%). The developed system also accounts for low organic solvent consumption, low operating costs, low generation of waste and high sample throughput (24 h(-1)). Due to the real time automated sampling and high throughput, transdermal permeation profiles of nanoformulations can be established within a time frame seldom observed by conventional techniques.

show abstract

Fully automated drug liberation apparatus for semisolid preparations based on sequential injection analysis

Cited by 22 publications

References 26 publications

Application of sequential injection analysis to pharmaceutical analysis

Application of sequential injection analysis to pharmaceutical analysis

Automated system for release studies of salicylic acid based on a SIA method

On-line automated evaluation of lipid nanoparticles transdermal permeation using Franz diffusion cell and low-pressure chromatography

Contact Info

Product

Resources

About