Automated system for release studies of salicylic acid based on a SIA method

Klimundová, Jana; Sklenářová, Hana; Schaefer, Ulrich F.; Solich, Petr

doi:10.1016/j.jpba.2004.08.018

Cited by 17 publications

(10 citation statements)

References 24 publications

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“…3,7,20 SA is an o-hydroxy benzoic acid and it belongs to group of nonsteroidal antiinflammatory drugs. 21 It is an active component of aspirin and the regular use of aspirin by adults appears to reduce the risk of many diseases. 3 Main risk with oral therapeutic doses of SA, is mostly gastrointestinal irritation.…”

Section: Introductionmentioning

confidence: 99%

“…To overcome this disadvantages, some studies were carried out related to the transdermal usage of it. 1,3,[21][22][23][24][25][26][27][28][29][30] Walkow and McGinity 25 studied the effect of physicochemical properties on the in vitro diffusion of salicylic acid (SA) through cellulose, dimethyl polysiloxane membranes and pig skin into a receptor phase of aqueous glycol, water and buffer solutions; they concluded that the SA diffusion was decreased as the receptor phase pH was lowered. Venkatesh et al 27 studied the in vitro release kinetics of SA from hydrogel patch formulations; they have determined that the release of SA followed the matrix diffusion controlled mechanism and the storage of the packaged formulations under ambient conditions for 9 months caused no change in the extent of SA release.…”

Section: Introductionmentioning

confidence: 99%

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In vitro release of salicylic acid through poly(vinyl alcohol‐g‐itaconic acid) membranes

Asman¹,

Şanlı²,

Tuncel³

2007

J of Applied Polymer Sci

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In this study, itaconic acid (IA) was grafted on poly(vinyl alcohol) (PVA) at two different grafting percentages, 7.0% (w/w) and 14.0% (w/w), and membranes were prepared from the grafted copolymer (PVA-g-IA). Performances of PVA and PVA-g-IA membranes for the transdermal release of salicylic acid (SA) at in vitro conditions were investigated by using 2.0 mg/mL SA solutions. Effect of the pH on the release of SA was studied by keeping pH of donor and acceptor solutions in a range of (2.1-7.4). Permeation studies were also carried on at different SA concentrations. Effect of temperature on the release of SA was investigated in the temperature range of (32-39) (61)8C. Results showed that presence of IA decreased the release of SA from the PVA membranes and 73% SA was released at the end of 48 h at (32 6 1)8C from the IA-1 membranes. pH affected the release of SA through the grafted membranes and studies showed that release of SA was high with donor solution pH of 2.1. When the pH of donor and receiver solutions were kept at the same pH value, the overall SA% in permeate increased. Increase in concentration of SA decreased the release of SA for the studied membranes. Release of SA from PVA-g-IA membranes was temperature sensitive and increase in temperature from (32 6 1)8C to (39 6 1)8C increased the release percentage of SA by 24% (w/w). The overall activation energy for the permeation of SA through IA-1 membrane was found to be 22.97 kJ/mol.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro release of salicylic acid through poly(vinyl alcohol‐g‐itaconic acid) membranes

Asman¹,

Şanlı²,

Tuncel³

2007

J of Applied Polymer Sci

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“…1ml of samples was withdrawn from the receptor compartment at pre-determined time intervals (0.5, 1, 2, 4, 6, 8, 10, 12 and 24 hrs) and an equal volume of buffer was replaced. The samples were analyzed after appropriate dilution for drug content spectrophotometrically at 261.8nm 17,18,19 .…”

Section: In Vitro Diffusion Studiesmentioning

confidence: 99%

Formulation and Evaluation of Transfersomal Cream of Acriflavine

Chaudhari¹,

Dharashivkar²,

Palkar³

et al. 2016

Int. Res. J. Pharm.

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A burn can be major medical problems or life-threatening emergencies admitted to any hospital. Conventional topical burn formulations are required to be applied 3 to 4 times a day and previous application is needed to be removed prior to application of each new dose which is very painful to burn patients. In this research an attempt was made to increase the patient compliance by reducing the dosing frequency through sustained release vesicular drug delivery system like transfersomes. Transfersomes were formulated using by thin film hydration method and evaluated for entrapment efficiency, photomicroscopy, scanning electron microscopy, vesicle size, polydispersity and zeta potential. Optimized Transfersomal batch was incorporated in cream base and evaluated for pH, spreadability, viscosity, drug content and in vitro diffusion. Transfersomes prepared by using 1:3 ratio of sodium cholate with cholesterol and 200 mg drug showed highest entrapment (91.65%) and sustained release (65.18% in was 24 hrs) was obtained with transfersomal cream in comparison with conventional formulation (97.54% in 8 hrs).

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“…Recently, the same authors applied the same system to evaluate the drug release from three different topical semisolid formulations containing 3% salicylic acid [151]. This system did not require any human control during the experiments and the possibility of coupling 6 Franz diffusion cells makes this system a useful tool for the release tests used during manufacturing process control, monitoring pre-and post-changes in product properties, monitoring batch uniformity as well as preformulation screening and product development.…”

Section: Automated Drug-dissolution and Drug-release Testingmentioning

confidence: 99%