Transportation's effects on health and well-being are widely recognized. In the near future, autonomous vehicles (AVs) are expected to revolutionize transportation options and ways of travel. Consequently, the effect of AVs on population health and well-being is a crucial topic of interest for transportation policymaking, one that has received comparatively little attention. This chapter discusses (and anticipates) potential AV impacts on health and well-being. First, we summarize knowledge surrounding effects of transportation on physical health (traffic safety, air and noise pollution, and physical activity) and well-being (travel satisfaction, access to activities, etc.). We then discuss how AVs may affect traveler behaviors, focusing on mode shifts toward private, shared, and/or