Fully automatic, microprocessor-controlled system for the production of 111CO2, 111CH3I and 111C-labeled radiopharmaceuticals

A one‐pot synthesis of [11C] labeled tamoxifen has been developed via reductive carboxylation. In this approach, [11C]CO2 is reacted with the N‐trimethylsilyl derivative of desmethyltamoxifen, followed by in situ sodium bis (2‐methoxyethoxy)aluminum hydride reduction, to afford impure [11C] labeled tamoxifen, which, on purification over a basic alumina‐silica gel column, provided pure [11C] tamoxifen in excellent radiochemical yield (65% to 84%) and radiochemical purity (>99%). The specific activity of [11C]tamoxifen was 250–400 Ci/mmol at the end of bombardment.

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A versatile, commercially available automated synthesizer for the development and production of pet radiotracers

Hostetler

Hamill

Francis

et al. 2001

Labelled Comp Radiopharmac

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The automation of routinely produced radiotracers is an important process for any PET center. Automation allows frequent, highly reproducible syntheses with large amounts of radioactivity while minimizing exposure to the radiochemist in comparison with manual radiotracer synthesis. We found the Gilson SK233 Work Station, coupled with Gilson's 735 Sampler Software and a Gilson SPE (solid phase extraction) module, to be a versatile, user-friendly, and cost-effective solution to our need for automation in the development and routine synthesis of radiotracers.

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Fully automatic, microprocessor-controlled system for the production of 111CO2, 111CH3I and 111C-labeled radiopharmaceuticals

Cited by 13 publications

References 5 publications

Remote controlled production of [2‐¹¹C] isopropyl iodide

Remote controlled production of [2‐¹¹C] isopropyl iodide

Direct incorporation of [¹¹C]carbon dioxide for labeling bioactive molecules. An application to [¹¹C] labeled tamoxifen

A versatile, commercially available automated synthesizer for the development and production of pet radiotracers

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Fully automatic, microprocessor-controlled system for the production of 111CO2, 111CH3I and 111C-labeled radiopharmaceuticals

Cited by 13 publications

References 5 publications

Remote controlled production of [2‐11C] isopropyl iodide

Remote controlled production of [2‐11C] isopropyl iodide

Direct incorporation of [11C]carbon dioxide for labeling bioactive molecules. An application to [11C] labeled tamoxifen

A versatile, commercially available automated synthesizer for the development and production of pet radiotracers

Contact Info

Product

Resources

About

Remote controlled production of [2‐¹¹C] isopropyl iodide

Remote controlled production of [2‐¹¹C] isopropyl iodide

Direct incorporation of [¹¹C]carbon dioxide for labeling bioactive molecules. An application to [¹¹C] labeled tamoxifen