Fully dilutable microemulsions embedded with phospholipids and stabilized by short-chain organic acids and polyols

Spernath, Aviram; Aserin, Abraham; Garti, Nissim

doi:10.1016/j.jcis.2006.02.024

Cited by 74 publications

(46 citation statements)

References 40 publications

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“…For development of a SEDDS formulation, the optimum ratios of excipient concentrations were established by means of phase diagram studies that identified the area of the monophasic region. It is important to determine this area in order to ensure successful aqueous dilution without "breaking" the microemulsions (23,24). The phase diagrams Fig.…”

Section: Pseudo-ternary Phase Diagramsmentioning

confidence: 99%

Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

et al. 2010

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Abstract. The objectives of this study were to develop and evaluate a novel self-emulsifying floating drug delivery system (SEFDDS) that resulted in improved solubility, dissolution, and controlled release of the poorly water-soluble tetrahydrocurcumin (THC). The formulations of liquid self-emulsifying drug delivery system (SEDDS; mixtures of Labrasol, Cremophor EL, Capryol 90, Labrafac PG) were optimized by solubility assay and pseudo-ternary phase diagram analysis. The liquid SEDDS was mixed with adsorbent (silicon dioxide), glyceryl behenate, pregelatinized starch, sodium starch glycolate, and microcrystalline cellulose and transformed into pellets by the extrusion/spheronization technique. The resulting pellets with 22% liquid SEDDS had a uniform size and good self-emulsification property. The microemulsions in aqueous media of different self-emulsifying floating pellet formulations were in a particle size range of 25.9-32.5 nm. Use of different weight proportions of glyceryl behenate and sodium starch glycolate in pellet formulations had different effects on the floating abilities and in vitro drug release. The optimum formulation (F2) had a floating efficiency of 93% at 6 h and provided a controlled release of THC over an 8-h period. The release rate and extent of release of THC liquid SEDDS (80% within 2 h) and self-emulsifying floating pellet formulation (80% within 8 h) were significantly higher than that of unformulated THC (only 30% within 8 h). The pellet formulation was stable under intermediate and accelerated storage conditions for up to 6 months. Controlled release from this novel SEFDDS can be a useful alternative for the strategic development of oral solid lipid-based formulations.

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Section: Pseudo-ternary Phase Diagramsmentioning

confidence: 99%

Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

et al. 2010

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“…It is known that lyotropic inverse (type II) mesophases are formed from lipids with CPP > 1 [42,43] or in phospholipid systems where alkanes have been added to increase the effective hydrophobic chain volume [44,45]. One example of the latter is phosphatidylcholine (PC), which is also known to enhance transdermal drug permeation [46][47][48] and transmembrane transport across the digestive tract, increasing the bioavailability of the guest molecules [49,50]. Moreover, since PC is a natural surfactant, it may be regarded as a useful compound for transdermal drug delivery.…”

Section: Effect Of Phosphatidylcholine On Gmo/tricaprylin/water Systemsmentioning

confidence: 99%

An HII liquid crystal-based delivery system for cyclosporin A: Physical characterization

Libster

Aserin

Wachtel

et al. 2007

Journal of Colloid and Interface Science

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“…3 Moreover, lecithins are found generally to be nonirritating and nonsensitising for human skin. 4 Lecithin exhibits a very strong hydrophobicity due to long hydrocarbon chains as well as a strong hydrophilicity due to the zwitterionic polar head groups, which have dipole moments.…”

Section: Introductionmentioning

confidence: 99%

Multinuclear NMR Characterisation and Dermal Delivery of Fluorinated Drugs in Soybean-Microemulsion Systems

Hoeller

Kählig

Valenta

2009

Journal of Pharmaceutical Sciences

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Fully dilutable microemulsions embedded with phospholipids and stabilized by short-chain organic acids and polyols

Cited by 74 publications

References 40 publications

Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

Controlled Release of Oral Tetrahydrocurcumin from a Novel Self-Emulsifying Floating Drug Delivery System (SEFDDS)

An HII liquid crystal-based delivery system for cyclosporin A: Physical characterization

Multinuclear NMR Characterisation and Dermal Delivery of Fluorinated Drugs in Soybean-Microemulsion Systems

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