Fully implantable neural recording and stimulation interfaces: Peripheral nerve interface applications

Deshmukh, Ashlesha; Brown, Logan Y.; Barbe, Mary F.; Braverman, Alan S.; Tiwari, Ekta; Hobson, Lucas J.; Shunmugam, Sudha; Armitage, Oliver; Hewage, Emil; Ruggieri, Michael R.; Morizio, James

doi:10.1016/j.jneumeth.2019.108562

Cited by 34 publications

(27 citation statements)

References 17 publications

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“…We have previously reported a former version of this technology (Deshmukh et al, 2020). The interfacing targets had been peripheral neural interfaces which are easier to interface with an implanted capsule.…”

Section: Design Of the Telemetric Brain-computer Interfacementioning

confidence: 99%

“…The real-time RF signal strengths of the radio communication were remotely monitored before and during the experiment to ensure its smooth running. The recording system was also synchronized with the stimulation system to automatically record stimulation pattern indicator pulses indicating the start and end of the stimulation (Deshmukh et al, 2020).…”

Section: Recording Systemmentioning

confidence: 99%

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An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Zaer

Deshmukh

Orłowski

et al. 2021

Front. Hum. Neurosci.

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Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

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Section: Design Of the Telemetric Brain-computer Interfacementioning

confidence: 99%

Section: Recording Systemmentioning

confidence: 99%

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Zaer

Deshmukh

Orłowski

et al. 2021

Front. Hum. Neurosci.

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“…However, because almost all peripheral nerves are mixed, stimulation-based therapeutic approaches require the separated regeneration of sensory and motor axons. The second reason is to connect the sensory and motor nerves of the amputees to the sensors and actuators of the bionic neuroprostheses that are being available in the market, which demand well-differentiated and ordered sensory and motor axons to be separately guided and connected to the artificial sensors and actuators (Raspopovic et al, 2014;Micera, 2016;Lee et al, 2018;Günter et al, 2019;Deshmukh et al, 2020).…”

Section: The Need Of An Ordered and Differentiated Regeneration Of Sementioning

confidence: 99%

Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves

Guedan-Duran

Jemni-Damer

Orueta-Zenarruzabeitia

et al. 2020

Front. Bioeng. Biotechnol.

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“…wheel chairs, 68 drug delivery devices 55,69 etc.). Wirelessly controlled bioelectronics can be useful for recording cellular activity (particularly from muscle and nerve tissues) 70–79 or indeed for the stimulation of such tissues, 80–83 with examples of systems capable of both recording and stimulation 84–86 …”

Section: Introductionmentioning

confidence: 99%

Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films

Ashton

Appen

Fırlak

et al. 2020

Polymer International

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The development of stimuli‐responsive drug delivery systems offers significant opportunities for innovations in industry. It is possible to produce polymer‐based drug delivery devices enabling spatiotemporal control of the release of the drug triggered by an electrical stimulus. Here we describe the development of a wireless controller for drug delivery from conductive/electroactive polymer‐based biomaterials and demonstrate its function in vitro. The wireless polymer conduction controller device uses very low power, operating at 2.4 GHz, and has a supply voltage controller circuit which controls electrical stimulation voltage levels. The computer graphical user interface program communicates with the controller device, and it receives device information, device status and temperature data from the controller device. The prototype of the wireless controller system can trigger the delivery of a drug, dexamethasone phosphate, from a matrix of degradable electroactive polymers. Furthermore, we introduce the application of in silico toxicity screening as a potentially useful method to facilitate the design of non‐toxic degradable electroactive polymers for a multitude of biotechnological applications, addressing one of the key commercial challenges to biomaterial development, in accordance with ‘safe by design’ principles. © 2020 The Authors. Polymer International published by John Wiley & Sons Ltd on behalf of Society of Industrial Chemistry.

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Fully implantable neural recording and stimulation interfaces: Peripheral nerve interface applications

Cited by 34 publications

References 17 publications

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Biomimetic Approaches for Separated Regeneration of Sensory and Motor Fibers in Amputee People: Necessary Conditions for Functional Integration of Sensory–Motor Prostheses With the Peripheral Nerves

Wirelessly triggered bioactive molecule delivery from degradable electroactive polymer films

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