Fulminant hepatitis in dengue haemorrhagic fever

Ling, L.M.; Wilder-Smith, Annelies; Leo, Yee‐Sin

doi:10.1016/j.jcv.2006.12.011

Cited by 76 publications

(65 citation statements)

References 23 publications

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“…Mild to moderately elevated serum aminotransferases (AST and ALT <5× normal) are common in DENV infection; however, liver dysfunction appears to be common in dengue hemorrhagic fever (severe dengue) (18). AST and ALT reached a level that was 5 times greater than the normal range in 11 (22%) and 7 (14%) cases, respectively, and usually reached the highest level a few days after fever resolution, as observed in Case 1.…”

Section: Discussionmentioning

confidence: 93%

Four Cases of Autochthonous Dengue Infection in Japan and 46 Imported Cases: Characteristics of Japanese Dengue

et al. 2015

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Objective A dengue outbreak occurred in Japan 2014. We investigated the characteristics of dengue infection among Japanese. Methods We investigated the medical charts retrospectively. Patients The study participants are patients who came to our clinic between 2008 and 2014. Results We investigated 4 domestic cases and 46 imported cases of Japanese with laboratory confirmation of dengue. Major symptoms were fever (100%), rash (86%), fatigue (84%), headache (81%), joint pain (66%), muscle pain (49%), and bleeding (6%). A late rash that appeared near the time of fever resolution was observed in 37 cases (74%). A total of 38/43 (88%) cases had low WBC count (<3,500/μL) during the febrile period, 42/48 (88%) cases had a low platelet (PLT) count (<130×10 3 /μL), and 44/50 (88%) cases had a C-reactive protein (CRP) <2.0 mg/dL. Conclusion Patients with a high fever, late rash, fever-associated leukopenia, low PLT count, low CRP, and elevated aminotransferases are generally suspected of having a dengue infection.

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Section: Discussionmentioning

confidence: 93%

Four Cases of Autochthonous Dengue Infection in Japan and 46 Imported Cases: Characteristics of Japanese Dengue

et al. 2015

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“…Dengue antigen has been identified within Kupffer cells, endothelium, lymphocytes and monocytes inside the lumen of sinusoidal capillaries of individuals presenting DF, DHF or DSS (Guzman et al 2002, Jessie et al 2004. Studies reported fatal hepatic failure in an adult arising as a complication of DHF (Lawn et al 2003, Ling et al 2007). Liver histology revealed marked steatosis and a florid hepatitis with necrosis.…”

Section: Discussionmentioning

confidence: 99%

Morphological Studies of Hepatic Tissue of Mice Reinfected With Dengue Virus Serotypes 1 or 2

Schatzmayr¹,

Takiya²,

Jácome³

et al. 2010

VR&R

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“…69 Acute liver failure (ALF) occurs less frequently and is seen mainly in children with upto 50% mortality, though it can also occur in adults. [70][71][72][73] Hepatic failure following DHF has been described earlier too. 74,75 Nonfatal Reye's syndrome confirmed by liver biopsy has also been described as a complication of DHF.…”

Section: Dengue Fevermentioning

confidence: 99%