Fulminant septicemia of Bacillus cereus resistant to carbapenem in a patient with biphenotypic acute leukemia

Kiyomizu, Kazunobu; Yagi, T.; Yoshida, Hitoshi; Minami, Ryota; Tanimura, Akira; Karasuno, Takahiro; Hiraoka, A

doi:10.1007/s10156-008-0627-y

Cited by 41 publications

(17 citation statements)

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“…1, all isolates of B. cereus in our study were susceptible to VCM and quinolones. However, partial resistance to CLDM and carbapenem was detected, similar to the results of previous basic research and a case report (14,15). Our clinical data suggest that carbapenem and CLDM are no longer appropriate choices for treating B. cereus, in accordance with findings that susceptibility to carbapenems has fallen in the S20 generation (http://www.…”

Section: Discussionsupporting

confidence: 81%

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A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

et al. 2012

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Objective Bacillus cereus (B. cereus) septicemia is a cause of life-threatening infection in patients with hematologic diseases. However, preventing a fatal prognosis in patients with B. cereus infection has not yet been achieved due to insufficient clinical investigations. To discover more optimal treatment strategies, we analyzed B. cereus septicemia in patients with hematologic diseases. Methods At our institution, we observed 13 cases of B. cereus septicemia in 12 patients with hematologic diseases between January 2001 and September 2010. The susceptibility of B. cereus strains to antibiotics was also analyzed. Results Of 12 patients, four died of B. cereus septicemia. In this study, the delayed administration of appropriate antibiotics (starting >24 hours after presentation), the presence of liver dysfunction and evidence of central nervous system (CNS) involvement tended to result in a fatal prognosis. All of the bacterial strains were found to be susceptible to vancomycin and quinolones (such as ciprofloxacin and levofloxacin), whereas many strains were resistant to clindamycin (76.9%) and imipenem (30.8%). In seven of 10 patients, central venous (CV) catheter tips were removed and routinely cultured. Catheter tip cultures were positive for B. cereus in three of seven patients. Conclusion Although not specific to B. cereus bacteremia, patients who died of B. cereus tended to present with CNS symptoms and/or liver dysfunction. Our clinical data suggested that carbapenem and clindamycin are no longer appropriate choices for treating B. cereus. In addition, B. cereus septicemia was found to frequently originate from CV catheters. Constant attention must be paid to update assessments of antibiotic susceptibility and careful management must be applied to CV catheters in patients with hematologic diseases.

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Section: Discussionsupporting

confidence: 81%

“…VCM or quinolones, but not carbapenems or CLDM, should be chosen to treat B. cereus septicemia (14,15). 4) If the patient has CNS symptoms, aggressive treatment options in addition to intravenous administration of antibiotics should be considered immediately (16,17).…”

Section: Discussionmentioning

confidence: 99%

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

et al. 2012

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“…acillus cereus is a ubiquitous spore-forming bacterium that has been isolated from people with food-borne illnesses and other infections (4,9,11,19). Food poisoning caused by B. cereus is divided into two types according to symptoms: vomiting type or diarrhea type.…”

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confidence: 99%

Complete Genome Sequence of Bacillus cereus NC7401, Which Produces High Levels of the Emetic Toxin Cereulide

Takeno

Okamoto

Tori

et al. 2012

Journal of Bacteriology

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“…To our knowledge, 46 B. cereus sepsis patients with hematologic malignancies have been previously reported (Akiyama, et al 1997, Arnaout, et al 1999, Christenson, et al 1999 et al 1981, Cone, et al 2005, Coonrod, et al 1971, Dohmae, et al 2008, Feldman and Pearson 1974, Frankard, et al 2004, Funada, et al 1988, Garcia, et al 1984, Gaur, et al 2001, Ginsburg, et al 2003, Ihde and Armstrong 1973, Jenson, et al 1989, Katsuya, et al 2009, Kawatani, et al 2009, Kiyomizu, et al 2008, Kobayashi, et al 2005, Kuwabara, et al 2006, Le Scanff, et al 2006 www.intechopen.com al 1977, Marley, et al 1995, Motoi, et al 1997, Musa, et al 1999, Nishikawa, et al 2009, Ozkocaman, et al 2006, Sakai, et al 2001, Strittmatter, et al 1995, Tomiyama, et al 1989, Trager and Panwalker 1979, Yoshida, et al 1993. On analyses of the clinical parameters of these patients, as in shown in Table 2, patients with acute leukemia, a neutrophil count of 0/mm 3 or below the lower limit of each institute, or CNS symptoms at febrile episodes were identified as risk factors closely correlated with a fatal prognosis (P=0.044, 0.004, and 0.002, respectively).…”

Section: Risk Factors For a Fatal Prognosis In Previously Reported Pamentioning

confidence: 99%

Bacillus cereus Sepsis in the Treatment of Acute Myeloid Leukemia

Inoue¹,

Takahashi²

2012

Myeloid Leukemia - Clinical Diagnosis and Treatment

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Fulminant septicemia of Bacillus cereus resistant to carbapenem in a patient with biphenotypic acute leukemia

Cited by 41 publications

References 9 publications

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

A Case Series of Bacillus Cereus Septicemia in Patients with Hematological Disease

Complete Genome Sequence of Bacillus cereus NC7401, Which Produces High Levels of the Emetic Toxin Cereulide

Bacillus cereus Sepsis in the Treatment of Acute Myeloid Leukemia

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