Fulminant Stenotrophomonas maltophilia Soft Tissue Infection in Immunocompromised Patients: An Outbreak Transmitted via Tap Water

Sakhnini, E.; Weissmann, A; Oren, Ilana

doi:10.1097/00000441-200205000-00008

Cited by 67 publications

(40 citation statements)

References 28 publications

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“…The variety of infections associated with S. maltophilia is shown in Table 1. Infections associated with S. maltophilia include (most commonly) respiratory tract infections (pneumonia [115,310] and acute exacerbations of chronic obstructive pulmonary disease [COPD] [101,247]); bacteremia (182,187,236); biliary sepsis (261); infections of the bones and joints, urinary tract, and soft tissues (33,191,297,343); endophthalmitis (4); eye infections (keratitis, scleritis, and dacryocystitis [202,224,370]); endocarditis (19,135,171,237,326); and meningitis (243,284). S. maltophilia is a significant pathogen in cancer patients, particularly those with obstructive lung cancer.…”

Section: S Maltophilia Was First Isolated In 1943 As Bacterium Bookementioning

confidence: 99%

“…In the health care environment, S. maltophilia has been isolated from several sources, including suction system tubing of dental chair units (DCUs) (250), contaminated endoscopes (179), and tap water (297), all of which present possible patient exposure sources. S. maltophilia-contaminated central venous catheters and tap water faucets have been implicated in cutaneous and soft tissue infections in patients with neutropenia (297).…”

Section: Nosocomial and Community-acquired Infectionsmentioning

confidence: 99%

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Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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SUMMARY Stenotrophomonas maltophilia is an emerging multidrug-resistant global opportunistic pathogen. The increasing incidence of nosocomial and community-acquired S. maltophilia infections is of particular concern for immunocompromised individuals, as this bacterial pathogen is associated with a significant fatality/case ratio. S. maltophilia is an environmental bacterium found in aqueous habitats, including plant rhizospheres, animals, foods, and water sources. Infections of S. maltophilia can occur in a range of organs and tissues; the organism is commonly found in respiratory tract infections. This review summarizes the current literature and presents S. maltophilia as an organism with various molecular mechanisms used for colonization and infection. S. maltophilia can be recovered from polymicrobial infections, most notably from the respiratory tract of cystic fibrosis patients, as a cocolonizer with Pseudomonas aeruginosa . Recent evidence of cell-cell communication between these pathogens has implications for the development of novel pharmacological therapies. Animal models of S. maltophilia infection have provided useful information about the type of host immune response induced by this opportunistic pathogen. Current and emerging treatments for patients infected with S. maltophilia are discussed.

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Section: S Maltophilia Was First Isolated In 1943 As Bacterium Bookementioning

confidence: 99%

Section: Nosocomial and Community-acquired Infectionsmentioning

confidence: 99%

Stenotrophomonas maltophilia: an Emerging Global Opportunistic Pathogen

2012

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“…Skin and soft tissue manifestations of S. maltophilia infection are becoming increasingly well recognized 8,9 , and are most frequently associated with posttraumatic, post-surgical, or burn-related wounds and chronic cutaneous ulcers 16 . Clinical manifestations include cellulitis, cellulitis-like skin lesions, infected mucocutaneous ulcers, EG and paronychia [7][8][9][10]18 .…”

Section: Discussionmentioning

confidence: 99%

“…Clinical manifestations include cellulitis, cellulitis-like skin lesions, infected mucocutaneous ulcers, EG and paronychia [7][8][9][10]18 . The route of transmission is mainly unknown but it seems likely that invasion takes place via defects in mucous membranes and by colonization of central venous catheters 10 .…”

Section: Discussionmentioning

confidence: 99%