Fulminant type 1 diabetes mellitus exhibits distinct clinical and autoimmunity features from classical type 1 diabetes mellitus in Chinese

Cheng, Zheng; Zhang, Zhou; Yang, Lin; Lin, Jian; Huang, Gan; Li, Xia; Zhou, Weidong; Wang, Xiangbing; Liu, Zhenqi

doi:10.1002/dmrr.1148

Cited by 41 publications

(47 citation statements)

References 26 publications

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“…Rare PF cases had been reported. In this article, we investigated 12 cases of PF found in China since 2003 and compared them with 20 female cases of child-bearing age with fulminant type 1 diabetes not associated with pregnancy (NPF) [10].…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of fulminant type 1 diabetes associated with pregnancy in China

Liu

Mao

et al. 2011

Endocrine

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To report 12 cases of pregnancy-associated fulminant type 1 diabetes mellitus (PF) found in China from 2003 to 2010. The clinical and biochemical characteristics of these cases with PF were compared with a group of cases of child-bearing age with fulminant type 1 diabetes that was not associated with pregnancy (NPF). The clinical and biochemical characteristics of 12 PF cases were analyzed retrospectively and then compared with those characteristics of 20 NPF cases in China. The difference between Chinese and Japanese PF cases was investigated. The mean values of the characteristics from PF and NPF cases in China, including postprandial serum C-peptide concentration, plasma glucose concentration, and serum chloride were different. Compared to the 22 PF cases in Japan, the mean age of these 12 PF cases was much younger. The mean fasting and postprandial serum C-peptide concentration level were lower, and the mean HbA1c levels was higher in 12 PF cases in China. Eight of 12 PF cases in China developed the disease during pregnancy. Other four PF case developed the disease within 2 weeks after delivery. 12 PF cases in China showed more severe beta-cell destruction, the prognosis of their fetuses was extremely poor.

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Section: Introductionmentioning

confidence: 99%

Clinical characteristics of fulminant type 1 diabetes associated with pregnancy in China

Liu

Mao

et al. 2011

Endocrine

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“…The high-risk HLA-DQB1*02/*0302 genotype has been reported to be more frequent in children diagnosed !2 years, who also more often present with DKA at diagnosis (11). In Japan and China, specific HLA-DR-DQ genotypes have been associated with autoantibody-negative diabetes, fulminant clinical symptoms and severe DKA (12,13).…”

Section: Introductionmentioning

confidence: 99%

Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis

Hekkala

Ilonen

Knip

et al. 2011

European Journal of Endocrinology

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Objective: Our purpose was to assess whether family history of diabetes or the HLA-DR-DQ genotype of the index case was associated with the frequency of diabetic ketoacidosis (DKA) at diagnosis of childhood type 1 diabetes. Patients and methods: The study cohort comprised 1518 children aged !15 years and diagnosed with type 1 diabetes in Finland in [2002][2003][2004][2005]. Family history of type 1 and type 2 diabetes among firstdegree relatives (FDRs) and grandparents was assessed at diagnosis. HLA-DR-DQ genotypes were analysed using time-resolved fluorometry. Results: In total, 12.6 and 1.7% of children had at least one FDR affected with type 1 or type 2 diabetes, respectively, and 6.6 and 34.8% had at least one grandparent with type 1 or type 2 diabetes. DKA (pH !7.30) occurred less frequently in children having a type 1 diabetes affected FDR (7.4 vs 20.5%, P!0.001). Type 2 diabetes among the parents or grandparents had no such effect. Lower risk HLA genotypes were observed to predispose to DKA (P!0.024). In a logistic regression analysis, the risk of DKA was independently associated with the absence of a family member affected by type 1 diabetes, the presence of a low-risk HLA genotype and older age at diagnosis (odds ratio 3.23, 1.45 and 1.07 respectively). Conclusion: The presence of type 1 diabetes in an FDR is associated with an decreased risk of DKA at diagnosis. The rate of DKA seems to be higher in children with lower HLA-conferred risk for type 1 diabetes.

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“…Kawabata et al (9) reported that homozygosity for DRB1*04:05-DQB1*04:01 was much higher in FTD (12.5%, odds ratio 11.2) than in the acute-onset (8.3%, odds ratio 7.1) and slowly progressive (7.1%, odds ratio 6.0) subtypes. Zheng et al (10) found that the most frequent haplotype was DQA1*03-DQB1*03:03 (18.4%) and the second was DQA1*01:02-DQB1*06:01 (15.8%) in Chinese populations.…”

Section: Discussionmentioning

confidence: 99%

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

Kim

Hahm

et al. 2012

Intern. Med.

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A 23-year-old pregnant woman had a stillbirth at 30 weeks gestation due to abrupt diabetic ketoacidosis. The patient had a normal HbA1c, severe hyperglycemia, negative islet cell autoantibodies, and very low insulin secretion capacity. The viral markers associated with fulminant type 1 diabetes were negative. The patient's human leukocyte antigen genotypes were DRB1*04:06 and DQB1*03:01/05:02, not common subtypes for fulminant type 1 diabetes. This is the first Vietnamese patient with fulminant type 1 diabetes mellitus.

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Fulminant type 1 diabetes mellitus exhibits distinct clinical and autoimmunity features from classical type 1 diabetes mellitus in Chinese

Abstract: fulminant T1DM is a distinct entity with unique clinical characteristics and may be mediated by multiple factors, including viral infection, pregnancy, and drug sensitivity syndrome, among others, in the presence of humoral and/or cellular autoimmunity and susceptible genetic background.

Cited by 41 publications

References 26 publications

Clinical characteristics of fulminant type 1 diabetes associated with pregnancy in China

Clinical characteristics of fulminant type 1 diabetes associated with pregnancy in China

Family history of diabetes and distribution of class II HLA genotypes in children with newly diagnosed type 1 diabetes: effect on diabetic ketoacidosis

The First Vietnamese Patient with Fulminant Type 1 Diabetes Mellitus

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