Fumigation of three major soil pests (<i>Agriotes lineatus, Diabrotica virgifera virgifera, Phyllopertha horticola</i>) with 3-octanone and 1-octen-3-ol enantiomers

Bourdon, Pascal; Zottele, Maria; Baxter, Ian H.; Myrta, A.; Midthassel, Audun; Wechselberger, Katharina F.; Khoja, Salim; Bull, James C.; Strasser, Hermann; Butt, Tariq M.

doi:10.1080/09583157.2022.2057436

Cited by 11 publications

(12 citation statements)

References 39 publications

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“…We propose that the function of toxocysts is to enable 3-octanone accumulation to a sufficiently high local concentration in a system functionally analogous to how the glandular trichomes of plants act as cellular factories for the biosynthesis and storage of large amounts of secondary metabolites providing the first line of defense against herbivores, insects, and pathogens ( 5 , 46 ). 3-Octanone is also present in the volatiles of many plants ( 47 , 48 ), indicating that this natural ketone might protect plants from herbivorous insects ( 49 ). In the future, we plan to investigate the molecular mechanism underlying toxocyst development by first identifying the causative mutations for lost paralytic capability in our suite of lot mutants.…”

Section: Discussionmentioning

confidence: 99%

A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone

Lee

Chang

et al. 2023

Sci. Adv.

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The carnivorous mushroom Pleurotus ostreatus uses an unknown toxin to rapidly paralyze and kill nematode prey upon contact. We report that small lollipop-shaped structures (toxocysts) on fungal hyphae are nematicidal and that a volatile ketone, 3-octanone, is detected in these fragile toxocysts. Treatment of Caenorhabditis elegans with 3-octanone recapitulates the rapid paralysis, calcium influx, and neuronal cell death arising from fungal contact. Moreover, 3-octanone disrupts cell membrane integrity, resulting in extracellular calcium influx into cytosol and mitochondria, propagating cell death throughout the entire organism. Last, we demonstrate that structurally related compounds are also biotoxic to C. elegans , with the length of the ketone carbon chain being crucial. Our work reveals that the oyster mushroom has evolved a specialized structure containing a volatile ketone to disrupt the cell membrane integrity of its prey, leading to rapid cell and organismal death in nematodes.

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Section: Discussionmentioning

confidence: 99%

A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone

Lee

Chang

et al. 2023

Sci. Adv.

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“…Most of these records explored plant sourced interactions with invertebrate target/effectors (Ayelo et al, 2022; Jermakowicz et al, 2022; Liang et al, 2021; Zhuo et al, 2022). The remaining two records explored interactions between invertebrate and fungal sources with invertebrate targets/effectors (Bourdon et al, 2022; Shi et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

“…Increased understanding of VOC‐mediated interactions has led to more recent research focusing on manipulating VOCs to benefit humans (Duan et al, 2021; Kim et al, 2020; Kraakman et al, 2021) and the environment (Liang et al, 2020; Zhao et al, 2020). Efforts have been made to exploit VOCs to improve food flavourings and aromas (Wu et al, 2022), drive medical advances (Wang et al, 2023) and engineering (Simasatitkul et al, 2017) as well as develop novel tools for crop and livestock protection (Bourdon et al, 2022; Hummadi et al, 2021; Khoja et al, 2019; Oyarzún et al, 2009). Two VOCs showing great potential are 1‐octen‐3‐ol and 3‐octanone, otherwise more commonly known as ‘the mushroom alcohols’ (Morath et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Exploiting volatile organic compounds in crop protection: A systematic review of 1‐octen‐3‐ol and 3‐octanone

Tonks

Roberts

Midthassel³

et al. 2023

Annals of Applied Biology

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The 21st century has brought new challenges to the agri‐food industry due to population growth, global warming, and greater public awareness of environmental issues. Ensuring global food security for future generations is crucial. However, pests, weeds, and diseases still significantly contribute to crop losses, and the availability of effective conventional synthetic pesticides is decreasing. To address this, new and diverse pest management tools are needed. One pest management tool showing potential for invertebrate pest management is the exploitation of volatile organic compounds (VOCs)—in particular, the compounds 1‐octen‐3‐ol and 3‐octanone. This review aims to explore the extent to which 1‐octen‐3‐ol and 3‐octanone show potential in the future management of invertebrate crop and animal pests. A significant increase in the rate of publication of literature on the use of 1‐octen‐3‐ol and 3‐octanone in crop protection since 2018 is identified by this review, therefore, showing the potential importance of these compounds for use in future pest management. This review also identifies key interactions between naturally occurring biosynthesised 1‐octen‐3‐ol and 3‐octanone, and a range of invertebrate targets. Many of these interactions with key crop pests are sourced from the taxonomic families Lamiaceae, Fabaceae, and Trichomaceae. However, analysis of the practical application of these sources in an integrated pest management programme identifies clear limitations with the use of naturally occurring biosynthesised 1‐octen‐3‐ol and 3‐octanone. Rather, future focus should be placed on the development and exploitation of synthesised nature identical 1‐octen‐3‐ol and 3‐octanone for use as a biopesticide product. Overall, 1‐octen‐3‐ol and 3‐octanone show potential for exploitation in future crop protection, being abundant in source and diversity of invertebrate interactions. However, their use as a naturally occurring biosynthesised chemical is likely not practical for direct implementation in crop protection. Rather, focus should be placed on the development and exploitation of synthesised nature identical variants of these compounds for use as a biopesticide.

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“…Such effects may eventually yield larger plant mass via increased acquisition of soil nutrients. Regulation of soil microbiota by such compounds may also confer physiological changes in the plant by altering nutrient uptake or reducing phytophagous microbiota and invertebrates that could lead to damage during growth phases [ 54 ]. Several previous studies have demonstrated that microbial VOCs are derived from fungi; Alternaria alternata [ 55 ] and Fusarium oxysporum [ 56 ] are also able to increase chlorophyll content and other photosynthetic parameters of plants.…”

Section: Discussionmentioning

confidence: 99%

Metarhizium brunneum (Hypocreales: Clavicipitaceae) and Its Derived Volatile Organic Compounds as Biostimulants of Commercially Valuable Angiosperms and Gymnosperms

Wood

Kortsinoglou

Khoja

et al. 2022

JoF

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Metarhizium brunneum is a highly effective entomopathogenic fungus that also functions as a plant biostimulant. It can act as both an endophyte and rhizosphere colonizer; however, the mechanisms driving biostimulation are multifactorial. In this work, oilseed rape (Brassica napus) seeds were grown in composts treated with different concentrations of M. brunneum strains ARSEF 4556 or V275, or the M. brunneum-derived volatile organic compounds 1-octen-3-ol and 3-octanone. Biostimulation efficacy was found to be strongly dose dependent. Concentrations of 1 × 106 conidia g−1 compost were found to be most effective for the M. brunneum, whereas dosages of 1 µL 100 g−1 compost were found to be efficacious for the volatiles. These optimized doses were assessed individually and in combined formulations with a hydrogel against oilseed rape (Brassica napus), sitka spruce (Picea sitchensis), maize (Zea mays) and strawberry (Fragaria annanassa). Both volatile compounds were highly effective biostimulants and were found to increase in biostimulatory efficiency when combined with M. brunneum conidia. Hydrogels were not found to interact with the growth process and may offer avenues for novel formulation technologies. This study demonstrates that Metarhizium-derived volatile organic compounds are actively involved in plant growth promotion and have potential for use in novel formulations to increase the growth of a wide range of commercially relevant crops.

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Fumigation of three major soil pests (Agriotes lineatus, Diabrotica virgifera virgifera, Phyllopertha horticola) with 3-octanone and 1-octen-3-ol enantiomers

Cited by 11 publications

References 39 publications

A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone

A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone

Exploiting volatile organic compounds in crop protection: A systematic review of 1‐octen‐3‐ol and 3‐octanone

Metarhizium brunneum (Hypocreales: Clavicipitaceae) and Its Derived Volatile Organic Compounds as Biostimulants of Commercially Valuable Angiosperms and Gymnosperms

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