Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa

Mattiello, Rita; Mallol, Javier; Fischer, Gilberto Bueno; Mocelin, Helena Teresinha; Rueda, Belkys; Sarria, Edgar E.

doi:10.1590/s1806-37132010000400010

Cited by 35 publications

(11 citation statements)

References 26 publications

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“…( 12 , 16 ) Spirometry was performed with a Vitalograph ALPHA spirometer (Vitalograph, Buckingham, UK) before and 10 min after the administration of an inhaled dose of albuterol (300 µg; Aerolin (r) ; GlaxoSmithKline plc, Ware, UK) with a valve spacer (Fisonair (r) ; GlaxoSmithKline plc). All children performed a 6MWT with SO 2 control.…”

Section: Methodsmentioning

confidence: 99%

“…( 12 , 16 ) A espirometria foi realizada com um espirômetro Vitalograph ALPHA (Vitalograph, Buckingham, Reino Unido) antes e 10 min depois da administração de 300 µg de salbutamol inalatório (Aerolin (r) ; GlaxoSmithKline plc, Ware, Reino Unido) com um espaçador valvulado (Fisonair (r) ; GlaxoSmithKline plc). Todas as crianças realizaram TC6 com controle de SO 2 .…”

Section: Métodosunclassified

“…( 11 , 12 ) The clinical course following the onset of OB is variable and depends on the volume of affected lung tissue. ( 1 ) Measures of clinical status and of the ability to perform physically demanding activities-such as the number of hospital admissions or missed school days, walk test distance, nutritional status, and oxygen saturation (SO 2 ) at rest or during exercise-facilitate the selection of appropriate clinical interventions.…”

Section: Introductionmentioning

confidence: 99%

“…( 11 , 12 ) O curso clínico após o aparecimento de BO é variável e depende do volume do tecido pulmonar afetado. ( 1 ) Medidas do estado clínico e da capacidade de realizar atividades físicas intensas - medidas como o número de internações hospitalares ou de dias de aula perdidos, a distância percorrida em testes de caminhada, o estado nutricional e a saturação de oxigênio (SO 2 ) em repouso ou durante o exercício - facilitam a seleção de intervenções clínicas apropriadas.…”

Section: Introductionunclassified

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CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results

et al. 2013

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OBJECTIVE: To determine whether air trapping (expressed as the percentage of air trapping relative to total lung volume [AT%]) correlates with clinical and functional parameters in children with obliterative bronchiolitis (OB). METHODS: CT scans of 19 children with OB were post-processed for AT% quantification with the use of a fixed threshold of −950 HU (AT%950) and of thresholds selected with the aid of density masks (AT%DM). Patients were divided into three groups by AT% severity. We examined AT% correlations with oxygen saturation (SO2) at rest, six-minute walk distance (6MWD), minimum SO2 during the six-minute walk test (6MWT_SO2), FVC, FEV1, FEV1/FVC, and clinical parameters. RESULTS: The 6MWD was longer in the patients with larger normal lung volumes (r = 0.53). We found that AT%950 showed significant correlations (before and after the exclusion of outliers, respectively) with the clinical score (r = 0.72; 0.80), FVC (r = 0.24; 0.59), FEV1 (r = −0.58; −0.67), and FEV1/FVC (r = −0.53; r = −0.62), as did AT%DM with the clinical score (r = 0.58; r = 0.63), SO2 at rest (r = −0.40; r = −0.61), 6MWT_SO2 (r = −0.24; r = −0.55), FVC (r = −0.44; r = −0.80), FEV1 (r = −0.65; r = −0.71), and FEV1/FVC (r = −0.41; r = −0.52). CONCLUSIONS: Our results show that AT% correlates significantly with clinical scores and pulmonary function test results in children with OB.

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Section: Methodsmentioning

confidence: 99%

Section: Métodosunclassified

Section: Introductionmentioning

confidence: 99%

Section: Introductionunclassified

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CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results

et al. 2013

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“…BO affects mainly male children during the first year of life. [1][2][3] Despite the lack of available epidemiology, there is a high prevalence in countries within the southern hemisphere, such as Argentina, Brazil, Chile and New Zealand. 4,5 There are several etiologies mentioned in the literature, including viral and bacterial infections, but the most frequent cause of BO in children is post-infectious, i.e.…”

Section: Introductionmentioning

confidence: 99%

Complication of post-infectious bronchiolitis obliterans (Swyer-James syndrome)

Vieira

Yamagishi

Vieira

et al. 2015

Rev. Assoc. Med. Bras.

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suMMary Swyer-James syndrome is a complication of post-infectious bronchiolitis obliterans that causes inflammation and fibrosis of the bronchial walls. There are two types: asymptomatic, with most cases diagnosed in adults during routine radiological examinations; and symptomatic, most commonly found in children. Here, we report the case of a 6-year-old child with recurrent dyspnea since the age of 3, who showed signs and symptoms of bronchiolitis obliterans and radiological signs of bronchial wall thickening and air trapping. The clinical and radiological findings led to the diagnosis of Swyer-James syndrome. Treatment of this syndrome is intended to reduce the pulmonary lesions and improve the patient's quality of life.

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Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans

2015

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Postinfectious bronchiolitis obliterans is a chronic incapacitating disease with persistent airway inflammation. However, the efficacy of systemic corticosteroids has never been studied systematically. In the presented case, serial spirometry, plethysmography measurements, and nocturnal oximetry demonstrated progressive decline in lung hyperinflation and air-trapping and improvement in expiratory function and nocturnal oxygenation during and after six three-day courses of high-dose methylprednisolone (30 mg/kg/day). At four months post treatment, most gain in lung function was lost suggesting the need for sustained immunosuppression. Randomized, controlled trials using serial plethysmography measurements, spirometry, and nocturnal oximetry could provide evidence for the management of postinfectious bronchiolitis obliterans.

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Função pulmonar de crianças e adolescentes com bronquiolite obliterante pós-infecciosa

Cited by 35 publications

References 26 publications

CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results

CT densitovolumetry in children with obliterative bronchiolitis: correlation with clinical scores and pulmonary function test results

Complication of post-infectious bronchiolitis obliterans (Swyer-James syndrome)

Efficacy of pulse methylprednisolone in a pediatric case of postinfectious bronchiolitis obliterans

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