Function and dynamics of aptamers: A case study on the malachite green aptamer

Wang, Tianjiao

doi:10.2172/964604

Cited by 6 publications

(1 citation statement)

References 27 publications

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“…Nucleic acid aptamers provide an alternative method for inhibitor development as well as target validation (Lee et al 2006;Kang et al 2012). Aptamer identification and characterization does not require detailed knowledge of the target (Wang 2009;Bunka et al 2010;Soontornworajit et al 2011;Binning et al 2012). However, in situations where detailed structural and functional information are available, aptamer development can be tailored to enhance the impact of aptamer binding by targeting aptamer interactions to functionally important regions.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Ebola virus VP35 first basic patch as a therapeutic target

Binning¹

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CHAPTER 1. INTRODUCTION time in Gaya's lab, he has provided guidance and support, and his general enthusiasm for science is contagious and fosters a stimulating learning environment which has helped me developed as an independent scientist. I would also like to give a special thanks to Dr. Daisy Leung. Through the help and mentorship of both Gaya and Daisy, I have grown as a student, a scientists, a colleague, and a person, and will forever be grateful for the guidance they have given me. I would also like to thank all of the member of the Amarasinghe lab whom I have had the privilege to work with. All of these individuals have invested their time to help assist me with experiments and training, and have always been available for me to exchange thoughts and ideas with. Additionally, they have been a source of support and encouragement, making each day in lab a new and enjoyable experience. I also thank my committee members, Dr. Kristen Johansen, Dr. Drena Dobbs, Dr. Michael Shogren-Knaak, and Dr. Scott Nelson, for their guidance, support, suggestions, and encouragement, as well as both the Iowa State University and Washington University communities for their rich learning environments. xiv Lastly, I would like to thank my family and friends for providing an invaluable support network. Through their continuous love and support, I had the courage to follow my dreams.

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Section: Discussionmentioning

confidence: 99%

Characterization of Ebola virus VP35 first basic patch as a therapeutic target

Binning¹

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Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells

Kadioglu¹,

Efferth²

2016

Invest New Drugs

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Bioinformatics screening and molecular docking analyses were utilized to select high affinity peptides targeting translationally controlled tumor protein (TCTP). Selected peptide aptamers were tested towards cancer cell lines with different levels of TCTP expression. One peptide (WGQWPYHC) revealed specific cytotoxicity according to the TCTP expression in tumor cells without affecting normal cells. Western blot analysis showed peptide-induced down-regulation of TCTP as primary target as well as of cell-cycle related downstream proteins (CDK2, CDK6, Cyclin D3) in MOLT-4 leukemia cells. "WGQWPYHC" deserves further analysis for targeted therapy of TCTP-expressing tumor cells. Graphical abstract Molecular docking on TCTP, cytotoxicity toward MOLT-4 leukemia cell line and downregulation of CDK2, CDK6, CyclinD3 and TCTP proteins.

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Prediction of aptamer–protein interacting pairs based on sparse autoencoder feature extraction and an ensemble classifier

Yang

Jia

2019

Mathematical Biosciences

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Function and dynamics of aptamers: A case study on the malachite green aptamer

Cited by 6 publications

References 27 publications

Characterization of Ebola virus VP35 first basic patch as a therapeutic target

Characterization of Ebola virus VP35 first basic patch as a therapeutic target

Peptide aptamer identified by molecular docking targeting translationally controlled tumor protein in leukemia cells

Prediction of aptamer–protein interacting pairs based on sparse autoencoder feature extraction and an ensemble classifier

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