Function of BCLAF1 in human disease (Review)

Yu, Zongdong; Zhu, Jie; Wang, Haibiao; Li, Hong; Jin, Xiaofeng

doi:10.3892/ol.2021.13176

Cited by 28 publications

(12 citation statements)

References 121 publications

(429 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another highly abundant immunopeptide is from BCLAF3 (regulator of apoptosis and transcription, B‐cell lymphoma‐2‐associated transcription factor 3). BCLAF1 is associated with a multitude of biological processes, such as DNA damage response, splicing, and processing of pre‐mRNA, T‐cell activation, lung development, muscle cell proliferation and differentiation, autophagy, ischemia–reperfusion injury, and viral infection 55 . In a mouse model, BCLAF3 may induce differentiation in gastric glands by suppressing Wnt signalling and Reg family gene expression.…”

Section: Resultsmentioning

confidence: 99%

Discovery of natural bispecific antibodies: Is psoriasis induced by a toxigenic Corynebacterium simulans and maintained by CIDAMPs as autoantigens?

Schröder

2024

Experimental Dermatology

View full text Add to dashboard Cite

The high abundance of Corynebacterium simulans in psoriasis skin suggests a contribution to the psoriasis aetiology. This hypothesis was tested in an exploratory study, where western blot (WB) analyses with extracts of heat‐treated C. simulans and psoriasis serum‐derived IgG exhibited a single 16 kDa‐WB‐band. Proteomic analyses revealed ribosomal proteins as candidate C. s.‐antigens. A peptidomic analysis unexpectedly showed that psoriasis serum‐derived IgG already contained 31 immunopeptides of Corynebacteria ssp., suggesting the presence of natural bispecific antibodies (BsAbs). Moreover, peptidomic analyses gave 372 DECOY‐peptides with similarity to virus‐ and phage proteins, including Corynebacterium diphtheriae phage, and similarity to diphtheria toxin. Strikingly, a peptidomic analysis for human peptides revealed 64 epitopes of major psoriasis autoantigens such as the spacer region of filaggrin, hornerin repeats and others. Most identified immunopeptides represent potential cationic intrinsically disordered antimicrobial peptides (CIDAMPs), which are generated within the epidermis. These may form complexes with bacterial disordered protein regions, representing chimeric antigens containing discontinuous epitopes. In addition, among 128 low‐abundance immunopeptides, 48 are putatively psoriasis‐relevant such as epitope peptides of PGE2‐, vitamin D3‐ and IL‐10‐receptors. Further, 47 immunopeptides originated from tumour antigens, and the endogenous retrovirus HERV‐K. I propose that persistent infection with a toxigenic C. simulans initiates psoriasis, which is exacerbated as an autoimmune disease by CIDAMPs as autoantigens. The discovery of natural BsAbs allows the identification of antigen epitopes from microbes, viruses, autoantigens and tumour‐antigens, and may help to develop epitope‐specific peptide‐vaccines and therapeutic approaches with antigen‐specific regulatory T cells to improve immune tolerance in an autoimmune disease‐specific‐manner.

show abstract

Section: Resultsmentioning

confidence: 99%

Discovery of natural bispecific antibodies: Is psoriasis induced by a toxigenic Corynebacterium simulans and maintained by CIDAMPs as autoantigens?

Schröder

2024

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…In addition, Kbz may be associated with diseases such as cancer. B cell lymphoma-2-associated transcription factor 1 (BCLAF1), a death-promoting transcriptional repressor, participates in various biological processes, including autophagy and DNA damage response, and is highly associated with the proliferation and drug-resistance of cancer ( Mou et al., 2020 ; Yu et al., 2022 ). Notably, it contains eight Kbz sites, therefore linking Kbz to tumor development.…”

Section: Resultsmentioning

confidence: 99%

HBO1 catalyzes lysine benzoylation in mammalian cells

et al. 2022

View full text Add to dashboard Cite

“…BCLAF is a multifunctional protein with an arginine-serine functional domain (RS domain) and DNA binding domain [28,29]. It plays an important role in various physiological processes in cells, including apoptosis, lung development, T cell activation, autophagy, DNA repair, and transcriptional regulation [30]. It was reported that dysregulated expression of the BCLAF1 is closely associated with cancer, and overexpression in Hela cells caused apoptosis, which implied that BCLAF1 could induce apoptosis [31].…”

Section: Discussionmentioning

confidence: 99%

A novel model-based identification and validation of pivotal RNA-binding protein in the evolution of glioma

Rui

Liu

et al. 2022

Preprint

View full text Add to dashboard Cite

Background Glioma is a primary malignant cancer of the most common and aggressive sort occurring in the neuroectoderm, with an extremely high incidence of morbidity, mortality, and recurrence. There are limited treatment options for glioma. It is recognized that dysregulation of RNA binding proteins (RBPs) is intimately involved in the occurrence and progression of multiple malignant cancers. However, the role of RBP in glioma is not fully understood. In the current study, we used a new model to predict the course of glioma development and prognosis related to RBP. Methods To begin with, we obtained RNA-seq profiles of glioma and matched clinical data from the Chinese Glioma Genome Data (CGGA) database. The unsupervised clustering algorithms such as the K-means clustering algorithm, t-SNE, U-MAP, and principal component analysis were used to identify tumor subtypes that were pivotal in the development of glioma. Subsequently the progression of tumor subtypes was determined by the MS scoring model and proposed time series analysis. Next, RBPs with a major role in the progression of glioma were identified by weighted gene co-expression network analysis and Lasso Cox regression models. Functional analysis of key RBP-related genes was performed by gene set enrichment analysis (GSEA) and the STRING database to reveal the potential mechanisms of the biomarker. Results A total of six tumor subgroups were identified and were strongly homogeneous among subgroups. The stages of progression of the six tumor subgroups were identified by the proposed time-series analysis and MS model. We confirmed that BCLAF1 was correlated with survival in glioma patients and was closely associated with the progression of glioma by weighted gene co-expression network analysis, Lasso Cox, and multivariate Cox regression analysis. Finally, Functional annotation shows that BCLAF1 may influence the progression of glioma through RNA shearing that affects cell cycle, Wnt signaling pathway, and other cancer development signals. Conclusions In summary, the present study first identified six subtypes of glioma progression as well as the malignancy ranking. Secondly, it was established that BCLAF1 could be used as an RBP-related prognostic marker with extremely important applications in the clinical diagnosis and personalized treatment of glioma.

show abstract

Function of BCLAF1 in human disease (Review)

Cited by 28 publications

References 121 publications

Discovery of natural bispecific antibodies: Is psoriasis induced by a toxigenic Corynebacterium simulans and maintained by CIDAMPs as autoantigens?

Discovery of natural bispecific antibodies: Is psoriasis induced by a toxigenic Corynebacterium simulans and maintained by CIDAMPs as autoantigens?

HBO1 catalyzes lysine benzoylation in mammalian cells

A novel model-based identification and validation of pivotal RNA-binding protein in the evolution of glioma

Contact Info

Product

Resources

About