Function of Posterior Columns in Man

Cook, Albert W.; Browder, E. Jefferson

doi:10.1001/archneur.1965.00460250076009

Cited by 96 publications

(24 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar dissociation between clinical sensory findings and SEP abnormalities has also been described in other central nervous system diseases [4,10,13,16]. More over, apparently severe morphological deficits of the dorsal columns are not necessarily connected with clini cal deficits [3,17]. The electrophysiological results are complementary to pathologic findings [2] which demon strated an involvement of the gracile tract in chronic ergotism.…”

Section: Discussionsupporting

confidence: 71%

Chronic Ergotamine Abuse: Evidence of Functional Impairment of Long Ascending Spinal Tracts

Ludolph

Husstedt²,

Schlake³

et al. 1988

Eur Neurol

View full text Add to dashboard Cite

22 migraine patients with a history of chronic ergotamine abuse were compared with 12 patients with a similar intake of dihydroergotamine. The study of somatosensory-evoked potentials showed that 50% of the patients with a history of ergotamine abuse had increased central conduction times after stimulation of the tibial nerve. Corticomotoneuronal latencies obtained by noninvasive electrical stimulation of the motor cortex were normal in 5 patients. The functional sensory deficits were not related to clinical impairment and were more frequently observed in patients with a comparatively high mean daily and cumulative intake.

show abstract

Section: Discussionsupporting

confidence: 71%

Chronic Ergotamine Abuse: Evidence of Functional Impairment of Long Ascending Spinal Tracts

Ludolph

Husstedt²,

Schlake³

et al. 1988

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…Vibratory sensation has been questioned as a proper dorsal column-mediated function. 47,48 Studies have suggested that combined lesions of dorsal and posterolateral columns are necessary to abolish the sense of vibration. 47,48 In the present study, we were unable to determine whether the observed deficits were the result of lesions including either or both the dorsal and posterolateral columns.…”

Section: Limitationsmentioning

confidence: 99%

“…47,48 Studies have suggested that combined lesions of dorsal and posterolateral columns are necessary to abolish the sense of vibration. 47,48 In the present study, we were unable to determine whether the observed deficits were the result of lesions including either or both the dorsal and posterolateral columns. Furthermore, we have found that vibration threshold can be difficult to determine correctly after SCI because of the distribution of vibration stimuli beyond the testing site to more rostral areas with preserved sensation, and the presence of spontaneous or evoked sensations that may be difficult to separate from true vibration sense (unpublished observations).…”

Section: Limitationsmentioning

confidence: 99%

Decreased Spinothalamic and Dorsal Column Medial Lemniscus-Mediated Function Is Associated with Neuropathic Pain after Spinal Cord Injury

Cruz-Almeida

Felix

Martinez‐Arizala

et al. 2012

Journal of Neurotrauma

View full text Add to dashboard Cite

Neuropathic pain (NP) after spinal cord injury (SCI) can significantly and negatively affect quality of life and is often refractory to currently available treatments. In order to find more effective therapeutic avenues, it would be helpful to identify the primary underlying pathophysiological mechanisms in each individual. The aim of the present study was to assess the relationship between the presence and severity of NP after SCI and measures of somatosensory function mediated via the dorsal column medial lemniscal (DCML) pathway and the spinothalamic tract (STT). Vibratory, mechanical, thermal, and pain thresholds measured in areas at and below the neurological level of injury (LOI) in persons with SCI and NP (SCI-NP, n=47) and in persons with SCI without NP (SCI-noNP, n=18) were normalized to data obtained from able-bodied pain-free control subjects (A-B, n=30). STT-mediated function at and below the LOI was significantly impaired in both SCI groups compared with A-B controls (p<0.001), but not significantly different between the two SCI groups (NP vs. no-NP). In contrast, the SCI-NP group had significantly greater impairment of DCML-mediated function at the LOI, as reflected by greater vibratory detection deficits (z=-3.89±0.5), compared with the SCI-noNP group (z=-1.95±0.7, p=0.034). Within the SCI-NP group, NP severity was significantly associated with increased thermal sensitivity below the LOI (r=0.50, p=0.038). Our results suggest that both impaired STT and DCML-mediated function are necessary for the development of NP after SCI. However, within the SCI-NP group, greater NP severity was associated with greater sensitivity to thermal stimuli below the LOI. This finding concurs with other studies suggesting that STT damage with some sparing is associated with NP.

show abstract

“…This is the area where extensive cross-connections within the propriospinal sys tem have been reported [10], and this is denser at the base of the dorsal funiculi [45,50], In addition to the short fibre multisynaptic pathways de scribed by Basbaum [3], also long second order fibres activated by high threshold noxious stimuli have been demonstrated by U ddenberg [46] and Petit [34] at this site. Very little deficit in perception of either nox ious or nonnoxious stimuli was observed by Cook and Browder [6] after surgical transection of the dorsal columns in patients with phantom limb pain. V ierck et al [47] reported that they do not affect pain threshold but do decrease pain reactivity in monkeys.…”

Section: Stereotactic Extralemniscal Myelotomymentioning

confidence: 79%

Spinal Cord Stereotactic Techniques re Trigeminal Nucleotomy and Extralemniscal Myelotomy

Schvarcz¹

1978

Stereotact Funct Neurosurg

View full text Add to dashboard Cite

The application of stereotactic techniques to the spinal cord as a logical sequel to percutaneous procedures have produced significant developments by enabling the functional exploration of different cord structures. Radiofrequency lesions were placed either at the spinal trigeminal nucleus, for facial pain of central origin such as postherpetic neuralgia or anesthesia dolorosa as well as for neoplastic pain of extensive craniofacial distribution, or at the central cord region to interrupt preferentially multisynaptic nonspecific pathways mainly for midline and/or bilateral pain but also for patients with respiratory inadequacy or for certain central pain states. Technical aspects are reported, and physiological correlates relevant to surgery are analyzed. Results, indications and limitations are discussed.

show abstract

Function of Posterior Columns in Man

Cited by 96 publications

References 7 publications

Chronic Ergotamine Abuse: Evidence of Functional Impairment of Long Ascending Spinal Tracts

Chronic Ergotamine Abuse: Evidence of Functional Impairment of Long Ascending Spinal Tracts

Decreased Spinothalamic and Dorsal Column Medial Lemniscus-Mediated Function Is Associated with Neuropathic Pain after Spinal Cord Injury

Spinal Cord Stereotactic Techniques re Trigeminal Nucleotomy and Extralemniscal Myelotomy

Contact Info

Product

Resources

About