Function of the Large Intestine of Man in Absorption and Excretion

Welch, C. Stuart; Wakefield, E. G.; Adams, Mildred

doi:10.1001/archinte.1936.00170160141008

Cited by 31 publications

(11 citation statements)

References 23 publications

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“…They found that iron injected in normal individuals did not result in an appreciable iron elimination and concluded that the excretory power of the gastro-intestinal tract was very limited. In a patient with an ileostomy stoma and isolated colon, Welch, Wakefield, and Adams (9) showed that feeding of large amounts of iron by mouth did not result in its excretion by the colon.…”

Section: Discussionmentioning

confidence: 99%

Radioactive Iron and Its Metabolism in Anemia

Hahn

Bale

Lawrence

et al. 1939

Journal of Experimental Medicine

144

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With the production of radioactive isotopes by the physicists and the concentration of naturally occurring isotopes by the chemists, the grateful physiologists have been presented with what may prove to be the "Rosetta Stone" for the understanding and study of body metabolism. The radioactive isotopes are "marked" elements which behave precisely like their inactive replicas in the physiology of the body but can be readily recognized as distinct entities wherever found. The radioactive isotope of iron used fortunately has a long life (half life 47 days) which covers ample time for prolonged study of iron metabolism and gives assurance to the student that this iron found in tissues, bones, or fluids is the iron introduced and not some other iron coming from body storage depots, hemolysis, or red cell wastage.The literature on iron metabolism is enormous but the net results are disappointing to say the least. Every hypothetical possibility has been championed by students but very few points have been settied to the satisfaction of all workers. One can scarcely suggest a single possibility without finding that it has been more or less vigorously supported by physiologists or physicians in the past. We feel that radioactive iron will be a means of settling many of these disputes but it is impossible at this time to review all these interesting hypotheses.

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Section: Discussionmentioning

confidence: 99%

Radioactive Iron and Its Metabolism in Anemia

Hahn

Bale

Lawrence

et al. 1939

Journal of Experimental Medicine

144

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“…With these species, in the upper part of the small intestine large quantities of Na are poured into the intestinal lumen together with the digestive juices (bile, pancreatic and intestinal juice) (Gamble, 1950;Sobotka, 1937;deBeer, Johnston & Wilson 1935). This Na is partly reabsorbed from the large intestine (Welch, Wakefield & Adams, 1936;Field, Swell, Dailey, Trout & Boyd, 1955;. This absorption can take place against a considerable concentration gradient (Visscher, Varco, Carr, Dean & Erickson, 1944;Budolfsen, 1954Budolfsen, , 1956Field, Swell, Flick & Dailey, 1954a;Spencer, Ross & LloydThomas, 1954;.…”

mentioning

confidence: 99%

The osmotic pressure and the concentration of some solutes of the intestinal contents and the faeces of the cow, in relation to the absorption of the minerals

Weerden

1961

J. Agric. Sci.

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In the cows' intestine there is no isotony with the blood serum. In the upper part of the small intestine the chyme is strongly hypertonic but as it passes along the intestinal tract to the large intestine it becomes more and more hypotonic. The hypertony in the small intestine is not due to inorganic elements but is caused by organic non-electrolytes.In the large intestine hypotony is the result of strong selective absorption of sodium against a concentration gradient.This is an important aspect of the sodium metabolism of the cow. Chlorine is also absorbed from the large intestine against a concentration gradient.

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“…The indicated process goes on until the food residues assume a solid consistency and are expelled as feces with little loss of valuable salts from the body. This conception in application to the calcium exchange of the intestine is supported by the finding that, contrary to the opinion of earlier authors, no calcium is excreted into the colon (17,18).…”

Section: Commentsmentioning

confidence: 80%