Function of the Ureter and Renal Pelvis

Zorgniotti, Adrian W.

doi:10.1097/00000658-195808000-00020

Cited by 29 publications

(61 citation statements)

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“…It is not unreasonable to assume that the GFR per nephron in chronic hydronephrosis is elevated. Although intrapelvic pressure rises sharply with acute obstruction of the ureter, it has been shown that with the persistence of obstruction the intrapelvic pressure falls gradually towards normal values (9). De (19).…”

Section: Resultsmentioning

confidence: 99%

“…This hypothesis would imply a reduced delivery of filtrate to the loop of Henle and the distal convoluted tubule and would, therefore, result in a pattern of nephron underperfusion (8). An alternative possibility is that the initially elevated intrapelvic pressure results in a reduction in nephron mass; the subsequent return of intrapelvic pressure towards normal might produce a compensatory increase in the rate of tubular flow in the residual nephrons (9). The increased rate of tubular flow could result from increased filtration per nephron or diminished proximal fractional reabsorption, or both.…”

mentioning

confidence: 99%

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Patterns of nephron perfusion in acute and chronic hydronephrosis.

Suki¹,

Eknoyan²,

Rector³

et al. 1966

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Patterns of nephron perfusion in acute and chronic hydronephrosis.

Suki¹,

Eknoyan²,

Rector³

et al. 1966

J. Clin. Invest.

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“…Narath proposed that longitudinally orientated muscle bundles were able to protect the canaliculi from reflux, by elevating the fornix against the ducti Bellini during contractions of the pelvis. Kiil (1957), however, found that intrapelvic pressure never increased greatly during contraction of the pelvis, and argued against the necessity for such a mechanism.…”

Section: Discussionmentioning

confidence: 99%

Function of smooth muscle of the rat renal pelvis—response of the isolated pelvis muscle to angiotensin and some other substances

Finberg

Peart

1970

British J Pharmacology

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Summary The circular component of the renal pelvis muscle of the rat appears as an intact band around the tip of the papilla. The isolated pelvis muscle strip showed spontaneous rhythmic contractions in Locke solution at 38° C. The rate of contractions corresponded with the rate of pressure fluctuations recorded during free‐flow from a ureteral catheter inserted up to the renal hilum of anaesthetized rats. Angiotensin and adrenaline (13 ng/ml) produced a rise in tone of the isolated pelvis muscle, and an increase in the rate of spontaneous contractions; noradrenaline produced mainly an increase in the amplitude and rate of spontaneous contractions. Angiotensin and noradrenaline injected intravenously also produced an increased rate of pressure fluctuations recorded from the ureteral catheter. Acetylcholine, nicotine and 5‐hydroxytryptamine had no effect on the isolated tissue, but isoprenaline was capable of causing a decrease, and tyramine an increase, in the rate of spontaneous contractions in high dose (0.33 μg/ml). An increase in the tone of the circular pelvis muscle could lead to a reversible obstruction of urine outflow from the kidney.

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“…The physiological function of ureteric afferent fibres is not known though they may be involved in the transmission of pain associated with ureteral obstruction or pathology (Kiil, 1957;Bretland 1972; Kiil & Setekleiv, 1973). To study the properties and function of these fibres we have used an in vitro preparation of the guinea-pig ureter which included the inferior mesenteric ganglion (IMG).…”

Section: Introductionmentioning

confidence: 99%

Stimulation of afferent fibres of the guinea‐pig ureter evokes potentials in inferior mesenteric ganglion neurones.

Amann¹,

Dray²,

Hankins³

1988

The Journal of Physiology

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SUMMARY1. Intracellular recordings were made from neurones of the guinea-pig inferior mesenteric ganglion (IMG) maintained in vitro with both ureters and major nerve trunks attached. Afferent fibres in the ureteric nerve were activated by electrical, chemical and mechanical stimuli.2. Repetitive stimulation of a ureteric nerve branch evoked a non-cholinergic, synaptic slow excitatory potential (slow EPSP) in 48 % of neurones. The amplitude of the slow EPSP was dependent on membrane potential and was decreased by membrane depolarization and increased by hyperpolarization.3. The slow EPSP was attenuated or abolished by capsaicin (1 /LM), which itself depolarized IMG neurones. Substance P (2 /M) or neurokinin A (2 #M) also depolarized IMG neurones and in the presence of these tachykinins the slow EPSP was attenuated or abolished. 4. Distension of the ureter evoked a non-cholinergic slow depolarization in 45 % of IMG neurones which was abolished by tetrodotoxin (1 /tM) and by capsaicin (1 JtM).5. Chemical stimulation of ureteric afferent nerve terminals by intralumenal perfusions of the ureter with capsaicin (1 uM) produced a slow depolarization in the IMG which was prevented by blocking nerve conduction with TTX.6. These data demonstrate that electrical stimulation of ureteric afferent fibres produces a non-cholinergic slow EPSP in the IMG. Primary afferent (capsaicinsensitive) C fibres are also activated by distension of the ureter and evoke a slow depolarization in the IMG. The synaptic mediator of these events is likely to be tachykinin(s) released from capsaicin-sensitive C fibres. These fibres may be mechanosensory and/or nociceptive.

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Function of the Ureter and Renal Pelvis

Cited by 29 publications

References 0 publications

Patterns of nephron perfusion in acute and chronic hydronephrosis.

Patterns of nephron perfusion in acute and chronic hydronephrosis.

Function of smooth muscle of the rat renal pelvis—response of the isolated pelvis muscle to angiotensin and some other substances

Stimulation of afferent fibres of the guinea‐pig ureter evokes potentials in inferior mesenteric ganglion neurones.

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