Few-shot relation extraction (FSRE) focuses on detecting new relations through a few annotated instances. Most existing works adopt prototypical network-based models for FSRE. They compute prototype representations for each class in the support set separately, and then use prototype representations for relation prediction. In this way, they learn only the knowledge of each class, regardless of the high-level interactions among these classes. However, these interactions can help the model understand diversity and improve discrimination, which is essential for FSRE, especially for similar relations’ prediction. In this work, we introduce a novel Biased Multi-granularity Interaction Prototype Network (BMIPN). Specifically, we mimic human cognitive processes to model explicit and adaptive interactions from intra- and inter-class aspects. Furthermore, we propose a novel biased contrastive learning method that encourages the model to focus on contrasting similar relations, generating discriminative and robust prototype representations. Experimental results on two benchmark datasets demonstrate that BMIPN outperforms state-of-the-art models and achieves better performance with respect to similar relations.