Functional 13C-urea and glucose hydrogen/methane breath tests reveal significant association of small intestinal bacterial overgrowth in individuals with active Helicobacter pylori infection

Anti-Helicobacter pylori treatment can effectively improve the clinical remission rates of irritable bowel syndrome: a controlled clinical trial meta-analysis

“…However, a similar meta-analysis by Ng et al (42) showed that there was no clear evidence to support an association between IBS and H. pylori; however this may be attributed to the smaller sample size in this study. Our results suggest that anti-H. pylori treatment could reduce IBS symptoms, and this may be mediated by the effects of anti-H. pylori treatments on gastrointestinal pH and flora changes, thereby promoting the recovery of the intestinal mucosal immune system and the gut-brain axis and restoring the regulation of the gastrointestinal hormone system (32). The specific mechanism underlying these effects is not yet clear, and further experiments are needed.…”

“…In addition, several papers have demonstrated a link between SIBO and H. pylori infection. Patients with H. pylori are more likely to test positive for SIBO ( 32 ). Further, H. pylori eradication therapy can effectively relieve the clinical symptoms of patients with SIBO ( 33 ), which also suggests there is some correlation between H. pylori infection, and SIBO and IBS.…”

Therapeutic efficacy of amoxicillin and rifaximin in patients with small intestinal bacterial overgrowth and Helicobacter pylori infection

“…Helicobacter pylori infection is mainly manifested by epigastric pain and the small intestinal bacterial overgrowth causes abdominal pain and bloating as well as abnormalities in bowel movements [ 15 ]. The above changes in gastric and intestinal microflora often coexist, which makes the diagnostic and therapeutic management difficult [ 16 – 18 ]. It is not always possible to determine the cause of ailments, the order of antibiotic treatment and which antibiotics will be effective.…”

Diagnosis of Helicobacter pylori infection

“…By combining 13 C‐UBT and glucose hydrogen/methane breath test (HMBT), H. pylori infection was shown to be significantly associated with the presence of small intestine bacterial overgrowth (SIBO) …”

“…45 By combining 13 C-UBT and glucose hydrogen/methane breath test (HMBT), H. pylori infection was shown to be significantly associated with the presence of small intestine bacterial overgrowth (SIBO). 46 Interestingly, some authors utilized the natural 13 C-and 18 O-urea normally present in human gastric juice by isotopic fractionation of breath CO 2 and tried to link the results to the disease status (PUD vs NUD) but more work still has to be carried out. 47 Finally a meta-analysis of the diagnostic accuracy of the 14 C-UBT was carried out in adult dyspeptic patients.…”