“…These early signs may manifest themselves as biological and physiological markers, but it is also possible General fatigue, referring to subject's general functioning, with statements such as 'I feel tired' Physical fatigue, bodily sensations directly referring to tiredness, e.g., 'Physically I only feel able to do a little' Reduced activity, a potential consequence of subjective fatigue, e.g., 'I think I do very little in a day' Reduced motivation, reflecting lack of will to start any activity, e.g., 'I dread having to do things' Mental fatigue, referring to cognitive symptoms such as having difficulty in concentration, e.g., 'It takes a lot of effort to concentrate on things' (36,43).…”