Functional Activity in the Effect of Transcranial Magnetic Stimulation Therapy for Patients with Depression: A Meta-Analysis

Deng, Yongyan; Li, Wenyue; Zhang, Bin

doi:10.3390/jpm13030405

Cited by 6 publications

(6 citation statements)

References 87 publications

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“…The reduced local activity in sensorimotor regions may be attributed to the consequence of exposure to treatments and depression-associated vulnerability. For treatment effects, a meta-analysis found that stimulation therapy for depression altered the activity in the right precentral gyrus, right posterior cingulate, left inferior frontal gyrus, and left middle frontal gyrus . After electroconvulsive therapy, fALFF was reported to decrease in the right precentral gyrus .…”

Section: Discussionmentioning

confidence: 99%

Lifetime Exposure to Depression and Neuroimaging Measures of Brain Structure and Function

Wang,

Hoffstaedter,

Kasper

et al. 2024

JAMA Netw Open

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ImportanceDespite decades of neuroimaging studies reporting brain structural and functional alterations in depression, discrepancies in findings across studies and limited convergence across meta-analyses have raised questions about the consistency and robustness of the observed brain phenotypes.ObjectiveTo investigate the associations between 6 operational criteria of lifetime exposure to depression and functional and structural neuroimaging measures.Design, Setting, and ParticipantsThis cross-sectional study analyzed data from a UK Biobank cohort of individuals aged 45 to 80 years who were enrolled between January 1, 2014, and December 31, 2018. Participants included individuals with a lifetime exposure to depression and matched healthy controls without indications of psychosis, mental illness, behavior disorder, and disease of the nervous system. Six operational criteria of lifetime exposure to depression were evaluated: help seeking for depression; self-reported depression; antidepressant use; depression definition by Smith et al; hospital International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10) diagnosis codes F32 and F33; and Composite International Diagnostic Interview Short Form score. Six increasingly restrictive depression definitions and groups were defined based on the 6 depression criteria, ranging from meeting only 1 criterion to meeting all 6 criteria. Data were analyzed between January and October 2022.Main Outcomes and MeasuresFunctional measures were calculated using voxel-wise fractional amplitude of low-frequency fluctuation (fALFF), global correlation (GCOR), and local correlation (LCOR). Structural measures were calculated using gray matter volume (GMV).ResultsThe study included 20 484 individuals with lifetime depression (12 645 females [61.7%]; mean [SD] age, 63.91 [7.60] years) and 25 462 healthy controls (14 078 males [55.3%]; mean [SD] age, 65.05 [7.8] years). Across all depression criteria, individuals with lifetime depression displayed regionally consistent decreases in fALFF, LCOR, and GCOR (Cohen d range, −0.53 [95% CI, −0.88 to −0.15] to −0.04 [95% CI, −0.07 to −0.01]) but not in GMV (Cohen d range, −0.47 [95 % CI, −0.75 to −0.12] to 0.26 [95% CI, 0.15-0.37]). Hospital ICD-10 diagnosis codes F32 and F33 (median [IQR] difference in effect sizes, −0.14 [−0.17 to −0.11]) and antidepressant use (median [IQR] difference in effect sizes, −0.12 [−0.16 to −0.10]) were criteria associated with the most pronounced alterations.Conclusions and RelevanceResults of this cross-sectional study indicate that lifetime exposure to depression was associated with robust functional changes, with a more restrictive depression definition revealing more pronounced alterations. Different inclusion criteria for depression may be associated with the substantial variation in imaging findings reported in the literature.

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Section: Discussionmentioning

confidence: 99%

Lifetime Exposure to Depression and Neuroimaging Measures of Brain Structure and Function

Wang,

Hoffstaedter,

Kasper

et al. 2024

JAMA Netw Open

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show abstract

“…For treatment effects, a meta-analysis found that stimulation therapy for depression altered the activity in the right precentral gyrus, right posterior cingulate, left inferior frontal gyrus, and left middle frontal gyrus. 31 After electroconvulsive therapy, fALFF was reported to decrease in the right precentral gyrus. 32 Additionally, antidepressant resulted in decrease in hyperconnectivity within the limbic system.…”

Section: Discussionmentioning

confidence: 99%

Effect of lifetime exposure to depression on brain structure and function in the UK Biobank

Wang,

Hoffstaedter,

Kasper

et al. 2023

Preprint

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Background: Depression is a common mental health condition in the general population. Whereas various neuroimaging studies have reported altered activity and structural impairments in depression, several recent meta-analyses only found small or inconsistent effects of depression. Different operational inclusion criteria and processing methodologies may contribute to these discrepancies. We addressed these issues by systematically testing for the effects of different criteria of lifetime exposure to depression on functional and structural neuroimaging measures in the UK biobank cohort. Methods: We included 36,359 participants (20,794 lifetime depression and 15,565 healthy individuals) from the UK biobank. Six increasingly conservative groups of lifetime depression were defined based on the six available depression criteria from meeting only one to more restrictive meeting all six criteria. We tested the effect of these definitions on voxel-wise measures of local functional activity, global connectivity and gray matter volume. Results: Across all depression definitions, individuals with lifetime depression displayed regionally consistent decreases in local functional activity alterations in sensorimotor cortex but not in global connectivity and gray matter volume alterations. More restrictive definitions and antidepressant usage resulted in most pronounced alterations. Conclusion: Lifetime exposure to depression is associated with robust functional changes with more restrictive criteria revealing more pronounced alterations. Different inclusion criteria of depression may strongly contribute to the substantial variation of imaging findings reported in the literature.

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“…A resting-state fMRI study has shown that the spontaneous brain activity of the precentral gyrus is reduced in MDD (Liang, Xue et al, 2020), while TMS treatment is associated with an increase in spontaneous brain activation in this region (Deng et al, 2023). A meta-analysis has also found that the gray matter volume of the precentral gyrus is reduced in depressed patients (Amidfar et al, 2021;Bora et al, 2012).…”

Section: Other Regionsmentioning

confidence: 99%

The Habenula in Mood Disorders: A Scoping Review of Human Studies

Fortin,

Lafleur,

Parisien

et al. 2024

Preprint

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In animal models, the habenula has been identified as a key structure involved in depression. Thanks to recent technological advancements, a burgeoning body of work has also investigated the habenula in the context of human mood disorders. This scoping review aims to synthesize findings from human studies that pertain to the habenula and its relationship with mood disorders. The review was conducted according to PRISMA guidelines. The literature search was performed with PubMed and yielded 93 articles, of which 50 articles were included in the review. We found that the evidence for baseline habenular hyperactivity in human depression is mixed. As for findings from resting-state functional connectivity (RSFC) studies, they were mainly inconsistent across studies. Moreover, we found no evidence indicating that mood disorders are linked to changes in the volume of the habenula. In order to enhance the replicability of findings, given the small size of the habenula, higher image resolution and larger samples are recommended for future studies.

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Functional Activity in the Effect of Transcranial Magnetic Stimulation Therapy for Patients with Depression: A Meta-Analysis

Cited by 6 publications

References 87 publications

Lifetime Exposure to Depression and Neuroimaging Measures of Brain Structure and Function

Lifetime Exposure to Depression and Neuroimaging Measures of Brain Structure and Function

Effect of lifetime exposure to depression on brain structure and function in the UK Biobank

The Habenula in Mood Disorders: A Scoping Review of Human Studies

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