Functional Activity of the Insulin Signaling System of the Brain in Health and Type 2 Diabetes Mellitus

Шпаков, А. О.

doi:10.1007/s11055-016-0385-8

Cited by 2 publications

(1 citation statement)

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“…Insulin signaling in brain plays an important role in the development and progression of diabetes mellitus [35], as well as diabetic encephalopathy [16]. This system of the brain is involved in the regulation of neuronal growth and synaptic plasticity and controls metabolic process in the CNS and periphery [36]. Depression symptoms and cognitive functions including spatial memory are associated with brain insulin resistance in type 2 diabetes [37, 38].…”

Section: Discussionmentioning

confidence: 99%

Chronic Unpredictable Mild Stress Aggravates Mood Disorder, Cognitive Impairment, and Brain Insulin Resistance in Diabetic Rat

Yang

Pan

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Diabetes-induced brain insulin resistance is associated with many mental diseases, including depression. Epidemiological evidences demonstrate the pathophysiologic link between stress, depression, and diabetes. This study was designed to determine whether chronic unpredictable mild stress- (CUMS-) induced changes in brain insulin resistance could contribute to deterioration in mood and cognitive functions in diabetic rats. Male SD rats were randomly assigned to three groups, including standard control group, the diabetes group, and the diabetes with CUMS group. After 7 weeks, emotional behaviors and memory performances as well as metabolic phenotypes were measured. In addition, we examined the changes in protein expression related to brain insulin signaling. Our results show that rats in diabetes with CUMS group displayed a decreased locomotor behavior in open-field test, an increased immobility time in forced swim test, and tail suspension test, and an impaired learning and memory in the Morris water maze when compared to animals in diabetes group. Further, diabetes with CUMS exhibited a significant decrease in phosphorylation of insulin receptor and an increase phosphorylation of IRS-1 in brain. These results suggest that the depression-like behaviors and cognitive function impairments in diabetic rats with CUMS were related to the changes of brain insulin signaling.

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