Functional and histological findings after obliteration of the periotic duct and endolymphatic sac in sound conditioned cats†

Schuknecht, Harold F.; Kimura, S.

doi:10.1288/00005537-195312000-00002

Cited by 49 publications

(6 citation statements)

References 6 publications

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“…Histopathologic examination initially revealed an enlarged endolymphatic space with no inflammatory change in patients with MD [1,2]. Subsequently, experimental hydrops in animals was developed, and these animals showed inner ear dysfunction [3,4]. Diuretic administration temporarily relieves the hearing impairment caused by MD, probably due to a reduction in hydrops [5].…”

Section: Introductionmentioning

confidence: 99%

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Uno¹,

Imai²,

Watanabe

et al. 2013

Acta Oto-Laryngologica

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Of seven patients with hydrops confirmed by MRI before surgery, both cochlear and vestibular hydrops became negative in two, cochlear hydrops became negative in one, both hydrops were present, but reduced, in one, and there was no change in three patients. The number of vertigo spells was reduced in all cases at 6-12 months after surgery. As for the three cases of negative hydrops, vertigo was completely suppressed. In two cases in which hearing level improved, hydrops became negative after surgery.

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Section: Introductionmentioning

confidence: 99%

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Uno¹,

Imai²,

Watanabe

et al. 2013

Acta Oto-Laryngologica

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“…Controlled animal models also support the hypothesis that injury to the ELD may create EH 13,14,15 . In primates, Swart and Schuknecht 14 obliterated the ELS with preservation of the labyrinth by way of the suboccipital approach.…”

Section: Discussionmentioning

confidence: 74%

“…Histological analysis of the cochleas of five monkeys revealed two with EH of the apical turn, one with EH of the apical and middle turns, and in two monkeys, all three turns demonstrated EH. Schuknecht and Kimura 15 observed mild EH in cats after ablation of the ELS. Even after survival times of three years, minimal hydrops was seen in the cats.…”

Section: Discussionmentioning

confidence: 98%

“…Controlled animal models also support the hypothesis that injury to the ELD may create EH. 13,14,15 In primates, Swart and Schuknecht 14 obliterated the ELS with preservation of the labyrinth by way of the suboccipital approach. Histological analysis of the cochleas of five mon-keys revealed two with EH of the apical turn, one with EH of the apical and middle turns, and in two monkeys, all three turns demonstrated EH.…”

Section: Discussionmentioning

confidence: 99%

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Endolymphatic Duct Status During Middle Fossa Dissection of the Internal Auditory Canal: A Human Temporal Bone Radiographic Study

et al. 2006

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The ELD is not vulnerable to injury during IAC dissection using the middle fossa approach. A previous radiographic study has shown that the ELD is violated in 24% of temporal bones during retrosigmoid dissection of the IAC. These findings support and may help explain other outcome studies that show that long-term hearing results are superior with the use of the middle fossa approach when compared to results following retrosigmoid dissection.

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“…The monkeys were studied up to 5 years and overall demonstrated a mild EH that did not progress with postoperative survival. Schuknecht and Kimura 13 observed mild EH in cats after ablation of the ELS. Even after survival times of 3 years, minimal hydrops was seen in the cats.…”

Section: Discussionmentioning

confidence: 98%

Endolymphatic Duct Violation During Retrosigmoid Dissection of the Internal Auditory Canal: A Human Temporal Bone Radiographic Study

et al. 2004

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The ELD is vulnerable to injury during IAC dissection even if labyrinthine structures at the lateral aspect of the IAC are preserved. These findings may be helpful in explaining and potentially preventing some cases of long-term hearing deterioration that may be a result of endolymphatic hydrops after ELD injury during acoustic tumor removal. Careful preoperative review of imaging studies using HRMCT may prove useful before retrosigmoid dissection.

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Functional and histological findings after obliteration of the periotic duct and endolymphatic sac in sound conditioned cats†

Cited by 49 publications

References 6 publications

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Changes in endolymphatic hydrops after sac surgery examined by Gd-enhanced MRI

Endolymphatic Duct Status During Middle Fossa Dissection of the Internal Auditory Canal: A Human Temporal Bone Radiographic Study

Endolymphatic Duct Violation During Retrosigmoid Dissection of the Internal Auditory Canal: A Human Temporal Bone Radiographic Study

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