Functional and morphological studies of peptide‐containing neuroendocrine cells in goldfish hypothalamus

Reaves, Troy Albert; Hayward, James N.

doi:10.1002/cne.901930313

Cited by 56 publications

(10 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AVT immunoreactivity in the POA and neurohypophysis of teleosts has been extensively investigated, and the organization of AVT-ir cells reported here largely conforms to an evolutionarily conserved pattern exhibited in other species (Gill et al, 1977;Goossens et al, 1977b;Reaves and Hayward, 1980;Schreibman and Halpern, 1980;van den Dungen et al, 1982;Cumming et al, 1982;Batten, 1986;Yulis and Lederis, 1987;Moons et al, 1988Moons et al, , 1989bOlivereau et al, 1988;Batten et al, 1990;Ekstrom, 1991, 1995;Foran and Bass, 1998). Similar data on hypophysial innervation are available for agnathans (Goossens et al, 1977a;Nozaki and Gorbman, 1983), dipnoids (Goossens et al, 1978), and elasmobranchs (Vallarino et al, 1990).…”

Section: Comparison With Avt Immunoreactivity In Other Vertebrate Taxasupporting

confidence: 79%

Vasotocin innervation and modulation of vocal-acoustic circuitry in the teleostPorichthys notatus

2000

View full text Add to dashboard Cite

Arginine vasotocin (AVT) and its mammalian homologue arginine vasopressin (AVP) modulate reproduction-related and other social behaviors in a broad range of vertebrate species. These functions of AVT/AVP may be in part achieved through the modulation of sensorimotor integration, although experimental evidence supporting this hypothesis remains limited. In the present experiments, we demonstrate (1) AVT innervation of candidate vocal-acoustic brain regions, and (2) AVT modulation of vocal-motor physiology in the plainfin midshipman fish (Porichthys notatus), which uses vocalizations in both mate attraction and agonistic contexts. AVT distribution was compared with known vocally active brain regions and to central auditory and vocal pathways. AVT-immunoreactive fibers and putative terminals descend almost exclusively from the preoptic area and are found in two primary candidate sites for vocal-acoustic integration - the anterior tuberal hypothalamus and paralemniscal midbrain tegmentum. AVT immunoreactivity is also located in several other vocally active regions, including the ventral tuberal nucleus, periaqueductal gray, and paraventricular regions of the isthmus and rostral hindbrain. The parvocellular preoptic area itself is also vocally active, although thresholds are substantially higher than for other regions. The functional significance of AVT input to vocal-acoustic regions was demonstrated in the paralemniscal midbrain where local delivery of AVT modulated electrically evoked, rhythmic vocal-motor output, which precisely mimicked natural vocalizations. AVT produced dose-dependent inhibitions of parameters associated with call initiation (burst latency and number of vocal-motor bursts elicited) but not of vocal-motor patterning (fundamental frequency and burst duration). Together, these findings provide support for the proposal that AVT modulates sensorimotor processes underlying social/acoustic communication.

show abstract

Section: Comparison With Avt Immunoreactivity In Other Vertebrate Taxasupporting

confidence: 79%

Vasotocin innervation and modulation of vocal-acoustic circuitry in the teleostPorichthys notatus

2000

View full text Add to dashboard Cite

show abstract

“…This is consistent with previous studies of the dipnoan lungfish (Reaves and Hayward, 1980), anuran amphibians (Vandesande and Dierickx, 1976;Conway and Gainer, 1987), reptiles (Goosens et al, 1979;Bons, 1983), birds (Bons, 1980), and several mammalian species Schimchowitsch et al, 1989).…”

Section: Vtir Cells Of the Diencephalonsupporting

confidence: 92%

Neuroanatomical distribution of vasotocin in a urodele amphibian (Taricha granulosa) revealed by immunohistochemical and in situ hybridization techniques

et al. 1997

View full text Add to dashboard Cite

Immunohistochemical and in situ hybridization techniques were used to investigate the neuroanatomical distribution of arginine vasotocin-like systems in the roughskin newt (Taricha granulosa). Vasotocin-like-immunoreactive neuronal cell bodies were identified that, based on topographical position, most likely, are homologous to groups of vasopressin-immunoreactive neuronal cell bodies described in mammals, including those in the bed nucleus of the stria terminalis, medial amygdala, basal septal region, magnocellular basal forebrain-including the horizontal limb of the diagonal band of Broca, paraventricular and supraoptic nuclei, suprachiasmatic nucleus, and dorsomedial hypothalamic nucleus. Several additional vasotocin-like-immunoreactive cell groups were observed in the forebrain and brainstem regions; these observations are compared with previous studies of vasotocin- and vasopressin-like systems in vertebrates. Arginine vasotocin-like-immunoreactive fibers and presumed terminals also were widely distributed with high densities in the basal limbic forebrain, the ventral preoptic and hypothalamic regions, and the brainstem ventromedial tegmentum. Based on in situ hybridization studies with synthetic oligonucleotide probes for vasotocin and the related neuropeptide mesotocin, as well as double-labeling studies with combined immunohistochemistry and in situ hybridization, we conclude that the vasotocin immunohistochemical procedures used identify vasotocin-like, but not mesotocin-like, elements in the brain of T. granulosa. The distribution of arginine vasotocin-like systems in T. granulosa is greater than the distribution previously reported for any other single vertebrate species; however, it is consistent with an emerging pattern of distribution of vasotocin- and vasopressin-like peptides in vertebrates. Complexity in the vasotocinergic system adds further support to the conclusion that this peptide regulates multiple neurophysiological and neuroendocrinological functions.

show abstract

“…Isotocin, as well as vasotocin, is produced in magnocellular and parvocellular neurons in the preoptic area. These neurons primarily project axons to the neurohypophysis (posterior pituitary) where isotocin and vasotocin are released into the systemic circulation (Batten et al 1990;Cumming et al 1982;Goossens et al 1977;Holmqvist and Ekstrom 1995;Reaves and Hayward 1980;Saito et al 2004;Van den Dungen et al 1982).…”

Section: Introductionmentioning

confidence: 99%

Zebrafish orthopedia (otp) is required for isotocin cell development

Eaton

Glasgow

2006

Dev Genes Evol

View full text Add to dashboard Cite

Several behavioral and physiological processes such as social, sexual, and maternal behaviors, learning and memory, and parturition are influenced by the neurohypophysial peptide oxytocin. Studies in knockout mice have identified four transcriptional regulatory genes that are required for oxytocin neuronal development in the hypothalamus. These are the basic helix-loop-helix PAS genes Single-minded 1 (Sim1) and Arylhydrocarbon receptor nuclear translocator 2 (Arnt2), the POU homeobox gene Pou3f2, and the paired homeobox gene Orthopedia (Otp). Overall, however, the molecular control of oxytocin cell development is poorly understood. Studies in zebrafish provide a complementary view to mouse knockout experiments and facilitate understanding of neuroendocrine cell development. Isotocin, which is orthologous to oxytocin, is expressed early in the developing zebrafish brain. In this paper we show that zebrafish otp mRNA expression in the embryonic forebrain is dynamic and complex, and that it overlaps with isotocin expression in the dorsal preoptic area. Additionally, these studies demonstrate that otp is required for isotocin cell development. Evidence is also provided that otp and sim1 function in parallel to direct the differentiation of isotocin cells, and that otp is unlikely to affect brain patterning. Overall, these studies support the hypothesis that the role of otp in zebrafish neuroendocrine cell development is evolutionarily conserved with that of mammals.

show abstract

Functional and morphological studies of peptide‐containing neuroendocrine cells in goldfish hypothalamus

Cited by 56 publications

References 31 publications

Vasotocin innervation and modulation of vocal-acoustic circuitry in the teleostPorichthys notatus

Vasotocin innervation and modulation of vocal-acoustic circuitry in the teleostPorichthys notatus

Neuroanatomical distribution of vasotocin in a urodele amphibian (Taricha granulosa) revealed by immunohistochemical and in situ hybridization techniques

Zebrafish orthopedia (otp) is required for isotocin cell development

Contact Info

Product

Resources

About