Functional and Structural Relationships in the Graafian Follicle Population of the Sheep Ovary

Hay, Mary F.; Moor, R. M.

doi:10.1530/jrf.0.0450583

Cited by 57 publications

(22 citation statements)

References 40 publications

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“…In agreement with Hay and Moor (1975a), we found very few membrane-bound bodies and rather few lipid droplets.…”

Section: Theca Internasupporting

confidence: 90%

Early Follicular Development and Atretic Changes in the Ovary of the Lamb? Fine Structure and Histochemistry

Tassell¹,

Jp²

1980

Aust. Jnl. Of Bio. Sci.

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The fine structure of follicles was studied in ovaries from lambs up to 32 days old. Some animals received pregnant mare serum gonadotrophin prior to sampling. Follicles examined were in the primordial to early antral stages. The oocyte is described and changes associated with its development and the formation of the zona pellucida are recorded. Characteristics in which the lamb oocyte differed from those of other mammals included a greater prominence of smooth endoplasmic reticulum, the presence of microtubules, fine filaments in the peripheral parts and a large number of almost empty vacuoles. The latter were more numerous in oocytes which appeared to be degenerating, including some of those in primordial follicles. Granulosa cells had characteristics usually associated with protein secretion while some theca cells had large amounts of endoplasmic reticulum bearing few ribosomes. In early atresia changes were evident successively in the oocyte, granulosa and theca.There was a weak positive reaction for 3p-hydroxy-AS-steroid dehydrogenase in the theca of some vesicular follicles from both control lambs and lambs treated with pregnant mare serum gonadotrophin. Follicles showing signs of atresia were negative for this enzyme.

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“…In agreement with Hay and Moor (1975a), we found very few membrane-bound bodies and rather few lipid droplets.…”

Section: Theca Internasupporting

confidence: 90%

Early Follicular Development and Atretic Changes in the Ovary of the Lamb? Fine Structure and Histochemistry

Tassell¹,

Jp²

1980

Aust. Jnl. Of Bio. Sci.

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“…By contrast, neither FSH nor LH seem to be able directly to induce the resumption of meiosis in oocytes within sheep, pig or human Graafian follicles maintained in organ culture (Baker and Neal, 1974 ;Hay and Moor, 1975 ;Baker et al, 1975 ;Biggs, Baker and Hutcheon, 1977 (Tsafriri, 1978).…”

mentioning

confidence: 99%

Interrelationships between the oocyte and somatic cells within the Graafian follicle of mammals

Baker¹,

Hunter²

1978

Ann. Biol. anim. Bioch. Biophys.

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“…The latter cells can be further subdivided into those which contact the basal lamina, the peripheral cells, and those which do not, the para-antral cells (Zoller and Weisz 1980). Cells in the deeper layers of the epithelium are closely apposed to their neighbours, while those near to the antrum are more loosely packed (Hay and Moor 1975a). Functional differences between the two populations are suggested by observations that the peripheral cells contain greater numbers of lipid droplets (Bjorkman 1962) and specific binding sites for human chorionic gonadotrophin (hCG) (Amsterdam et al 1975), and a higher content of cytochrome P-450 (Zoller and Weisz 1978), glucose-6-phosphate dehydrogenase and i15-3P-hydroxysteroid dehydrogenase (3P-HSD) (Zoller and Weisz 1979).…”

Section: Follicular Epitheliummentioning

confidence: 99%

“…The major ultrastructural features of follicular epithelial cells at various stages of follicular growth have now been documented in several species including the rat (Bjorkman 1962), cow (Priedkalns and Weber 1968), sheep (Hay and Moor 1975a;Cran et al 1979), Rhesus monkey (Amin et al 1976) and man (Mestwerdt et al 1977). In preantral and antral follicles these cells have a relatively high nuclear: cytoplasmic ratio, and contain a wide range of cytoplasmic organelles.…”

Section: Follicular Epitheliummentioning

confidence: 99%

“…Gap junctions, whose role in intercellular communication is now well established (Evans 1980), are also present in many species including the rat (Merk et al 1973), rabbit (Albertini and Anderson 1974), Rhesus monkey (Zamboni 1974), sheep (Hay and Moor 1975a), man (Fukushima 1977) and mouse (Burghardt and Anderson 1978). Morphologically these junctions take two major forms, termed abutment and annular nexuses (Merk et al 1973).…”

Section: Follicular Epitheliummentioning

confidence: 99%

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Structure-Function Relationships in the Wall of the Ovarian Follicle

O’Shea¹

1981

Aust. Jnl. Of Bio. Sci.

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This paper reviews current knowledge of the light and electron microscopic structure of the three layers of the mammalian follicular wall-follicular epithelium (membrana granulosa), theca interna and theca externa-and discusses correlations between structure and function. The ultrastructure of follicular epithelial cells in growing follicles emphasizes their protein synthetic and secretory functions; features suggestive of a major steroidogenic function appear only at later stages. Regional differences in follicular epithelial cell function are probably important, although structurally these cells are relatively homogeneous. Structural diversity is more marked in the thecal layers : differentiation in the theca interna is towards fibrocytic and steroidogenic cell types, while that in the theca externa is towards fibrocytic and myoid types. Adherens and gap junctions are present between cells in all layers; however, tight (occludens) junctions have not been convincingly demonstrated between the cells in any of the three layers. Blood and lymph vessels are confined to the thecal layers. However, follicles possess no structural barrier comparable to that associated with the 'blood-testis barrier', and show a correspondingly greater permeability to large molecules than seminiferous tubules. Interactions between the layers of the follicular wall have not yet been intensively investigated, but are likely to play an important role in follicular function. To date, the best-documented interaction between layers is that described in the 'two-cell hypothesis' of oestrogen production. Some potentially useful directions for future research are proposed.

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Functional and Structural Relationships in the Graafian Follicle Population of the Sheep Ovary

Cited by 57 publications

References 40 publications

Early Follicular Development and Atretic Changes in the Ovary of the Lamb? Fine Structure and Histochemistry

Early Follicular Development and Atretic Changes in the Ovary of the Lamb? Fine Structure and Histochemistry

Interrelationships between the oocyte and somatic cells within the Graafian follicle of mammals

Structure-Function Relationships in the Wall of the Ovarian Follicle

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