Functional anti-bone tumor biomaterial scaffold: construction and application

Abstract

Bone tumors, including primary bone tumors and bone metastases, have been plagued by poor prognosis for decades. Although most tumor tissue is removed, clinicians are still confronted with the dilemma...

Advances in the Application of Photothermal Composite Scaffolds for Osteosarcoma Ablation and Bone Regeneration

“…Despite the high selectivity, low toxicity , and high tumor treatment efficiency of PTT, nanomaterials usually cannot repair bone defects caused by bone tumor surgery . To address this need for postoperative bone repair, researchers are focusing on developing photothermal composite scaffolds that can promote regeneration and have therapeutic effects in osteosarcoma treatment. , Zhang et al constructed a novel bone scaffold with nanohydroxyapatite (n-HA), MXene nanosheets, and g-C 3 N 4 . The scaffold has excellent photothermal properties and can be rapidly heated up to 45 °C in about 3 min under 808 nm laser irradiation.…”