Functional Architecture of the Retromer Cargo-recognition Complex

Effantin, Grégory; Hierro, Aitor; Rojas, A.L.; Rojas, Raúl; Murthy, Namita; Kajava, AV; Bonifacino, Juan S.; Hurley, JH; Steven, A. Williams

doi:10.1017/s1431927608086200

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“…The retromer complex consists of multiple vacuolar protein sorting proteins, which are associated with the cytoplasmic surface of the endosomes and mediate the retrograde transport of the transmembrane cargo in endosome-to-Golgi transport [ 2 , 3 ]. Vps29 is a key component of the cargo-binding core complex of the retromer, a protein assembly with diverse roles in the transport of receptors within the endosomal system.…”

Section: Introductionmentioning

confidence: 99%

The Retromer Subunit CfVps29 Is Involved in the Growth, Development, and Pathogenicity of Colletotrichum fructicola

2022

JoF

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Camellia oleifera is an edible oil tree species native to China. Anthracnose is a common disease of Ca. oleifera, which reduces the production of the trees and brings huge economic losses. We have previously identified the fungus Colletotrichum fructicola as the major pathogen of anthracnose in Ca. oleifera. The retromer complex participates in the intracellular retrograde transport of the cargos from the endosome to the trans-Golgi network in the eukaryotes. Vacuolar protein sorting 29 is a subunit of the retromer complex. Targeted CfVPS29 gene deletion revealed that CfVps29 is involved in growth, conidiation, and the response to cell wall stress. We further found that the ΔCfvps29 mutant was minimally pathogenic to Ca. oleifera leaves, as a result of its defect in appressorium formation. This study illustrated the crucial functions of CfVps29 in the development, cell wall stress response, and pathogenicity of C. fructicola and, therefore, identified it as a potential fungicide target for the control of anthracnose.

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Section: Introductionmentioning

confidence: 99%

The Retromer Subunit CfVps29 Is Involved in the Growth, Development, and Pathogenicity of Colletotrichum fructicola

2022

JoF

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“…The retromer complex consists of multiple vacuolar protein sorting proteins, which are associated with the cytoplasmic surface of endosomes and mediate the retrograde transport of transmembrane cargo endosome-to-Golgi transport [ 7 , 8 ]. The retromer complex allows receptor proteins to be recycled repeatedly, thus avoiding lysosomal degradation and maintaining the metabolic balance [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Retromer subunit, CfVps35 is required for growth development and pathogenicity of Colletotrichum fructicola

Zhang

2022

BMC Genom Data

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Background Tea oil is widely used as edible oil in China, which extracted from the seeds of Camellia oleifera. In China, the national oil-tea camellia planting area reached 4.533 million hectares, the output of oil-tea camellia seed oil was 627 000 tons, and the total output value reached 18.3 billion dollars. Anthracnose is the common disease of Ca. oleifera, which affected the production and brought huge economic losses. Colletotrichum fructicola is the dominant pathogen causing anthracnose in Ca. oleifera. The retromer complex participates in the intracellular retrograde transport of cargos from the endosome to the trans-Golgi network in eukaryotes. Vacuolar protein sorting 35 is a core part of the retromer complex. This study aimed to investigate the role of CfVps35 in C. fructicola. Results The CfVPS35 gene was deleted, resulting in reduced mycelial growth, conidiation, and response to cell wall stresses. Further analysis revealed that CfVps35 was required for C. fructicola virulence on tea oil leaves. In addition, the ΔCfvps35 mutant was defective in glycogen metabolism and turgor during appressorium development. Conclusion This study illustrated that the crucial functions of CfVps35 in growth, development, and pathogenicity.

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Functional Architecture of the Retromer Cargo-recognition Complex

Abstract: Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008

Cited by 2 publications

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The Retromer Subunit CfVps29 Is Involved in the Growth, Development, and Pathogenicity of Colletotrichum fructicola

The Retromer Subunit CfVps29 Is Involved in the Growth, Development, and Pathogenicity of Colletotrichum fructicola

Retromer subunit, CfVps35 is required for growth development and pathogenicity of Colletotrichum fructicola

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