Functional B-cell response in intrahepatic lymphoid follicles in chronic hepatitis C

Murakami, Jun; Shimizu, Yukihiro; Kashii, Yoshiro; Kato, Tsutomu; Minemura, Masami; Okada, Kazuhiko; Nambu, Shuji; Takahara, Taro; Higuchi, Kenichi; Maeda, Yoshinobu; Kumada, Tokimasa; Watanabe, Akïharu

doi:10.1002/hep.510300107

Cited by 127 publications

(92 citation statements)

References 47 publications

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“…As of 1996, when the highly active antiretroviral therapy (HAART) was first used in AIDS patients, potentially fatal co-morbidities, among them HCV infection, have been considered increasingly important 2,15,19 .…”

Section: Introductionmentioning

confidence: 99%

Clinical laboratory assessment of hepatitis C and HIV coinfected patients according to the antiretroviral therapy received

Navarro

Mendes-Corrêa

Cavalheiro

et al. 2005

Rev. Inst. Med. trop. S. Paulo

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SUMMARYDuring the year of 2001, a retrospective, descriptive study in order to determine the influence of the antiretroviral therapy received by 111 HIV-HCV coinfected patients who had undergone at least one liver biopsy was conduced, 74 of them were treated with a protease inhibitor regimen (WPI), and 37 with a non-protease inhibitor regimen (NPI). The main characteristics found were: a young patient population (mean age 41 years old in both groups), composed in most part of male individuals (74.3% WPI and 51.4% NPI) with previous risk factors for both infections (WPI 93.2% and NPI 89.2%). The most significant findings included AIDS-defining disease (WPI 18.9% and NPI 13.5% of the cases), elevated hepatic enzyme levels (WPI: SGOT 52.1 and NPI 53.2), absence of liver disease-related symptoms (16.2% for both groups), average CD4 count > 350 for both groups (WPI 362.2 and NPI 378.1), predominantly low-grade fibrosis in both populations (0-2 in 63.6% of WPI patients and in 80% of NPI patients), with necro-inflammatory activity ranging from 5-7 in 51.3% and 42.9% of WPI patients and NPI patients, respectively. It is suggested a sequential biopsy to better evaluate the evolution of the hepatic disease, according to the HAART regimen received.

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Section: Introductionmentioning

confidence: 99%

Clinical laboratory assessment of hepatitis C and HIV coinfected patients according to the antiretroviral therapy received

Navarro

Mendes-Corrêa

Cavalheiro

et al. 2005

Rev. Inst. Med. trop. S. Paulo

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“…The best characterized de novo lymphoid tissue is the tertiary lymphoid organ (TLO), 3 a structure resembling a lymph node that includes high endothelial venules (HEVs), well-defined T cell and B cell zones, and a germinal center accompanying follicular dendritic cells (2). TLO has been reported in various chronic inflammatory conditions such as autoimmune (3,4) and chronic infectious diseases (5,6).…”

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confidence: 99%

The Role of Intrapulmonary De Novo Lymphoid Tissue in Obliterative Bronchiolitis after Lung Transplantation

Sato

Hirayama

Hwang

et al. 2009

The Journal of Immunology

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Chronic rejection after lung transplantation is manifested as obliterative bronchiolitis (OB). The development of de novo lymphoid tissue (lymphoid neogenesis) may contribute to local immune responses in small airways. Compared with normal lungs, the lung tissue of 13 lung transplant recipients who developed OB demonstrated a significantly larger number of small, airway-associated, peripheral node addressin-positive (PNAd+) high endothelial venules (HEVs) unique to lymphoid tissue (p < 0.001). HEVs were most abundant in lesions of lymphocytic bronchiolitis and “active” OB infiltrated by lymphocytes compared with those of “inactive” OB. T cells in lymphocytic bronchiolitis and active OB were predominantly of the CD45RO+CCR7− effector memory phenotype. Similar lymphoid tissue was also observed in the rat lung after intrapulmonary transplantation of allograft trachea (Brown Norway (BN) to Lewis), but not after isograft transplantation. Subsequent orthotopic transplantation of the recipient Lewis lung containing a BN trachea into an F1 (Lewis × BN) rat demonstrated stable homing of Lewis-derived T cells in the lung and their Ag-specific effector function against the secondary intrapulmonary BN trachea. In conclusion, we found de novo lymphoid tissue in the lung composed of effector memory T cells and HEVs but lacking delineated T cell and B cell zones. This de novo lymphoid tissue may play a critical role in chronic local immune responses after lung transplantation.

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“…T ertiary lymphoid structures (TLS) 3 are recognized in multiple inflammatory tissues in both mice and humans, including rheumatoid arthritis (1-4), multiple sclerosis (5,6), myasthenia gravis (7,8), and chronic hepatitis C (9,10). These organized aggregates of lymphocytes are induced by inflammation, unlike those in developmentally programmed secondary lymphoid organs (spleen and lymph nodes) which they resemble.…”

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confidence: 99%

Tertiary Lymphoid Structures in the Pancreas Promote Selection of B Lymphocytes in Autoimmune Diabetes

Kendall¹,

Yu²,

Woodward

et al. 2007

The Journal of Immunology

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Autoimmune diabetes occurs when invading lymphocytes destroy insulin-producing β cells in pancreatic islets. The role of lymphocytic aggregates at this inflammatory site is not understood. We find that B and T lymphocytes attacking islets in NOD mice organize into lymphoid structures with germinal centers. Analysis of BCR L chain genes was used to investigate selection of B lymphocytes in these tertiary lymphoid structures and in draining pancreatic lymph nodes. The pancreatic repertoire as a whole was found to be highly diverse, with the profile of L chain genes isolated from whole pancreas differing from that observed in regional lymph nodes. A Vκ14 L chain predominated within the complex pancreatic repertoire of NOD mice. Skewing toward Vκ4 genes was observed in the pancreas when the repertoire of NOD mice was restricted using a fixed Ig H chain transgene. Nucleotide sequencing of expressed Vκs identified shared mutations in some sequences consistent with Ag-driven selection and clonal expansion at the site of inflammation. Isolated islets contained oligoclonal B lymphocytes enriched for the germinal center marker GL7 and for sequences containing multiple mutations within CDRs, suggesting local T-B interactions. Together, these findings identify a process that selects B lymphocyte specificities within the pancreas, with further evolution of the selected repertoire at the inflamed site. This interpretation is reinforced by Ag-binding studies showing a large population of insulin-binding B lymphocytes in the pancreas compared with draining lymph nodes.

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Functional B-cell response in intrahepatic lymphoid follicles in chronic hepatitis C

Cited by 127 publications

References 47 publications

Clinical laboratory assessment of hepatitis C and HIV coinfected patients according to the antiretroviral therapy received

Clinical laboratory assessment of hepatitis C and HIV coinfected patients according to the antiretroviral therapy received

The Role of Intrapulmonary De Novo Lymphoid Tissue in Obliterative Bronchiolitis after Lung Transplantation

Tertiary Lymphoid Structures in the Pancreas Promote Selection of B Lymphocytes in Autoimmune Diabetes

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