Functional, bioactive, biochemical, and physicochemical properties of the Dolichos lablab bean

Habib, Hosam M.; Theuri, Serah; Kheadr, Ehab; Mohamed, Fedah E.

doi:10.1039/c6fo01162d

Cited by 45 publications

(29 citation statements)

References 28 publications

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“…Lablab beans are less attractive to the public. If examined further, in addition to the potential as a source of nutrition, lablab bean also contains various bioactive compounds [24]. The existence of these bioactive compounds can potentially act as a natural medicine for various diseases [25].…”

Section: Introductionmentioning

confidence: 99%

The Diversity of Seed Size and Nutrient Content of Lablab Bean from Three Locations in Indonesia

Purwanti¹,

Prihanta²,

Fauzi³

2019

IJAEMS

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Lablab bean (Dolichos lablab L.) is one of the legume species that have the potential as an alternative food source for Indonesian people. The purpose of this study was to examine the diversity of seed size and nutritional content of six lablab bean accessions found in the Madura, Probolinggo, and West Nusa Tenggara (WNT), Indonesia. Morphological observations of seeds which included parameters of length, width, thickness, and seed weight, while the nutrient content of seeds was obtained from proximate analysis which included assay of fat, protein, and amylose. Data analysis used in this study wasa one-way analysis of variance and Pearson Product Moment test. The results of the analysis showed that the variety of accessions had a significant effect on all morphological parameters and nutrient levels studied. Besides, the results of data analysis also inform that some morphological parameters and nutrient content have a significant correlation.The findings of this study also show that lablab seeds contain high protein and amylose, so the use of this plant as alternative food in Indonesia is highly recommended.

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Section: Introductionmentioning

confidence: 99%

The Diversity of Seed Size and Nutrient Content of Lablab Bean from Three Locations in Indonesia

Purwanti¹,

Prihanta²,

Fauzi³

2019

IJAEMS

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“…( 13 ) Upon studies including bioactive, biochemical, physicochemical, and functional properties of NKM 23-1, Dolichos lablab L., contains many health-promoting components such as fiber, proteins, minerals, and numerous phytochemicals like flavonoids, saponins, and polyphenols. ( 14 ) Based on these characterizations, we have found the quite cytoprotective outcome of NKM 23-1 in HCl- or ethanol-stimulated gastric ulcer models.…”

Section: Introductionmentioning

confidence: 79%

<i>Dolichos lablab</i> L. extracts as pharmanutrient for stress-related mucosal disease in rat stomach

Kim

Lee

et al. 2020

J. Clin. Biochem. Nutr.

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Gastric stress-related mucosal disease (SRMD) presented from superficial gastritis to deep ulceration consequent to insufficient perfusion, ischemia, and oxidative stress. Though pharmacologic interventions to optimize tissue perfusion or to enhance defensive mechanism are essential, limited clinical outcome necessitates strong acid suppressors or natural agents. Under the hypothesis that Dolichos lablab L. (NKM 23-1) can enhance defense against SRMD, water immersion restraint stress (WIRS) were imposed to rats and additional groups pretreated with differing doses of NKM 23-1 were monitored. On gross and microscopic evaluation, they significantly rescued SRMD ( p <0.01). The levels of inflammatory mediators such as IL-18, IL-1β, IL-8, iNOS, TNF-α, caspase-1, NOXs as well as MMPs accompanied with NF-κB p50 activation were all significantly increased in WIRS, but their levels were significantly decreased in Groups pretreated with NKM 23-1. WIRS significantly increased apoptosis, but significantly decreased with NKM 23-1 accompanied with significantly increased levels of cyclin D/E and HSP70/HSP27. Gastric mucin was significantly preserved in Groups pretreated with NKM 23-1, while depleted in WIRS, accompanied with increased expressions of Muc5A. Gastric levels of HO-1 and NQO1 were significantly increased in Group treated with NKM 23-1 with transcriptional activation of Nrf2. Conclusively, preemptive intake of NKM 23-1 significantly rescued SRMD.

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“…Several bioactive compounds were reported to be contained in DL, including gallic acid, 4-hydroxy-3-methoxybenoic acid, p-coumaric acid, ferulic acid, cinnamic acid, catechin, and rutin. Also, saturated and unsaturated fatty acids, terpenoids, and steroids were found as a constituent inside DL beans (Baba et al, 1983;Bahtiar et al, 2017;Habib et al, 2017b;Yoshikawa et al, 1998). Previously, DL was explored for its antioxidant, antidiabetic, antimicrobial, and even antiinflammatory properties (Habib et al, 2017a;Naeem et al, 2020;Rahman and Akhter, 2018;Yin et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Exploring public health benefits of Dolichos lablab as a dietary supplement during the COVID-19 outbreak: A computational study

Purwanti¹,

Hermanto²,

Wiliem³

et al. 2020

J Appl Pharm Sci

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The emerging case of coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndromecoronavirus (SARS-CoV-2) virus has become a global health issue. Since there is no available developed vaccine, health-promoting foods play a vital role in maintaining the immune system against the disease. Dolichos lablab (DL), an unutilized highly nutritional legume, has an excellent potential to cope with this pandemic with various health benefit phytochemicals. This study appraised the possibility of phytochemical content from DL to prevent virus infection and hyperinflammation in COVID-19 in silico. DL's phytochemicals from liquid chromatography-high-resolution mass spectrometry analysis were docked with several SARS-CoV-2 proteins, including main protease and HR. Also, NF-κB docking was executed to pursue anti-inflammatory properties. The drug-likeness properties of screened phytochemicals were then evaluated using SwissADME. According to the results, there were 16 phytochemicals with a high affinity to targeted proteins. Among those, five phytochemicals consistently gave a low binding affinity to all targeted proteins. Those five phytochemicals' physicochemical properties, except for rutin and (9cis)-retinal, also coped with small-molecule bioavailability, permeability, and flexibility according to the SwissADME calculations. In conclusion, DL has a high probability of complementing the medical effort as dietary supplementation to modulate the immune system and prevent viral infection.

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Functional, bioactive, biochemical, and physicochemical properties of the Dolichos lablab bean

Cited by 45 publications

References 28 publications

The Diversity of Seed Size and Nutrient Content of Lablab Bean from Three Locations in Indonesia

The Diversity of Seed Size and Nutrient Content of Lablab Bean from Three Locations in Indonesia

<i>Dolichos lablab</i> L. extracts as pharmanutrient for stress-related mucosal disease in rat stomach

Exploring public health benefits of Dolichos lablab as a dietary supplement during the COVID-19 outbreak: A computational study

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