Functional boundaries in the human cerebellum revealed by a multi-domain task battery

King, Maedbh; Hernandez‐Castillo, Carlos R.; Poldrack, Russell A.; Ivry, Richard B.; Diedrichsen, Jörn

doi:10.1038/s41593-019-0436-x

Cited by 520 publications

(774 citation statements)

References 43 publications

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“…Finally, we also did not find a link between response-characteristics of the distractor task and classification in the cerebellar clusters, which also speaks against a motor-related interpretation of our findings. Instead, recent systematic evaluations of cerebellar activity across a large battery of tasks (King, Hernandez-castillo, Poldrack, Ivry, & Diedrichsen, 2019;Stoodley, Valera, & Schmahmann, 2012) produced a pattern comparable to ours when subjects performed mental rotation. Specifically, the activity across the left intercrural fissure that we see in the univariate results (Figure 3 left flatmap), and the medial portions in lobule VIIb of the more posterior cluster in the multivariate connectivity results (Figure 3 right flatmap) align well with the data produced by King and colleagues (2019).…”

Section: A Novel Cerebellar-hippocampal Connection For Visuospatialsupporting

confidence: 80%

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Hauser

Heba

Schmidt‐Wilcke

et al. 2019

Human Brain Mapping

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In addition to its role in visuospatial navigation and the generation of spatial representations, in recent years, the hippocampus has been proposed to support perceptual processes. This is especially the case where high‐resolution details, in the form of fine‐grained relationships between features such as angles between components of a visual scene, are involved. An unresolved question is how, in the visual domain, perspective‐changes are differentiated from allocentric changes to these perceived feature relationships, both of which may be argued to involve the hippocampus. We conducted functional magnetic resonance imaging of the brain response (corroborated through separate event‐related potential source‐localization) in a passive visuospatial oddball‐paradigm to examine to what extent the hippocampus and other brain regions process changes in perspective, or configuration of abstract, three‐dimensional structures. We observed activation of the left superior parietal cortex during perspective shifts, and right anterior hippocampus in configuration‐changes. Strikingly, we also found the cerebellum to differentiate between the two, in a way that appeared tightly coupled to hippocampal processing. These results point toward a relationship between the cerebellum and the hippocampus that occurs during perception of changes in visuospatial information that has previously only been reported with regard to visuospatial navigation.

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Section: A Novel Cerebellar-hippocampal Connection For Visuospatialsupporting

confidence: 80%

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Hauser

Heba

Schmidt‐Wilcke

et al. 2019

Human Brain Mapping

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show abstract

“…Tracer studies identify polysynaptic connections between the prefrontal cortex and the lateral portions of crus I and II as well as vermal lobules VII and IX (Bostan et al, 2013), largely overlapping with our MD cerebellar regions. In addition, previous studies have implicated similar cerebellar regions in several aspects of complex cognitive activity (King et al, 2019) as well as encoding task-relevant information (Balsters et al, 2013). Importantly, MD cerebellar regions do not overlap with motor-related regions (Diedrichsen and Zotow, 2015).…”

Section: Discussionmentioning

confidence: 99%

A Domain-general Cognitive Core defined in Multimodally Parcellated Human Cortex

Assem

Glasser

Essen

et al. 2019

Preprint

192

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AbstractNumerous brain imaging studies identified a domain-general or “multiple-demand” (MD) activation pattern accompanying many tasks and may play a core role in cognitive control. Though this finding is well established, the limited spatial localization provided by traditional imaging methods precluded a consensus regarding the precise anatomy, functional differentiation and connectivity of the MD system. To address these limitations, we used data from 449 subjects from the Human Connectome Project, with cortex of each individual parcellated using neurobiologically grounded multi-modal MRI features. The conjunction of three cognitive contrasts reveals a core of 10 widely distributed MD parcels per hemisphere that are most strongly activated and functionally interconnected, surrounded by a penumbra of 17 additional areas. Outside cerebral cortex, MD activation is most prominent in the caudate and cerebellum. Comparison with canonical resting state networks shows MD regions concentrated in the fronto-parietal network but also engaging three other networks. MD activations show modest relative task preferences accompanying strong co-recruitment. With distributed anatomical organization, mosaic functional preferences, and strong interconnectivity, we suggest MD regions are well positioned to integrate and assemble the diverse components of cognitive operations. Our precise delineation of MD regions provides a basis for refined analyses of their functions.

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“…Topographic representation of variation in brain structure, function and connectivity usually follows one of two paradigms: i) a mosaic of discrete parcels separated by hard boundaries [2][3][4]15 ; and more recently, ii) gradients of continuous topographic variation 12-14, 16, 23, 36 . We Hierarchy is a hallmark of brain organization 37 .…”

Section: Reconciling Parcellations and Gradientsmentioning

confidence: 99%

Topographic organization of the human subcortex unveiled with functional connectivity gradients

Margulies

Breakspear

Zalesky

2020

Preprint

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Understanding the topographic organization of the human brain remains a major goal in neuroscience. Brain atlases are fundamental to this goal, yet many contemporary human atlases cover only the cerebral cortex, leaving the subcortex a terra incognita. We revealed the astoundingly complex topographic organization of the human subcortex by disambiguating smooth connectivity gradients from discrete areal boundaries in resting-state fMRI data acquired from more than 1000 healthy adults. This unveiled four hierarchical scales of subcortical organization, recapitulating well-known anatomical nuclei at the coarsest scale and delineating 27 new bilateral regions at the finest. Ultra-high field strength fMRI corroborated and extended this hierarchy, enabling delineation of finer subdivisions of hippocampus and amygdala, while task-evoked fMRI revealed a subtle reorganization of subcortical topography in response to changing cognitive demands. A new subcortical atlas was delineated, personalized to account for individual connectivity differences and utilized to uncover reproducible relationships between subcortical connectivity and individual variation in human behaviors. The new atlas enables holistic connectome mapping and characterization of cortico-subcortical connectivity.

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Functional boundaries in the human cerebellum revealed by a multi-domain task battery

Cited by 520 publications

References 43 publications

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

Cerebellar‐hippocampal processing in passive perception of visuospatial change: An ego‐ and allocentric axis?

A Domain-general Cognitive Core defined in Multimodally Parcellated Human Cortex

Topographic organization of the human subcortex unveiled with functional connectivity gradients

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